CALCOCO2

CALCOCO2
已知的結構
PDB	人類UniProt搜索：PDBe RCSB
PDBID列表
	3VVV、3VVW、4GXL、4HAN、2MXP、4XKL
標識符
代號	CALCOCO2
擴展標識	OMIM：604587；HomoloGene：31339；GeneCards：CALCOCO2；OMA：CALCOCO2 - orthologs
基因位置（人類）
染色體	17號染色體
終止	48,866,522 bp
RNA表達模式
	Top expressed in
	right lung; ; epithelium of colon; ; left testis; ; right testis; ; tibial arteries;
	無數據
	查閱更多表達數據
	查閱更多表達數據
基因本體
分子功能	血漿蛋白結合; protein homodimerization activity;
細胞組分	細胞質; 細胞質的核周區域; 自噬體; autophagosome membrane; 細胞骨架; 膜; cytoplasmic vesicle; 細胞核; 細胞內膜結合細胞器; 細胞質基質;
生物學過程	自噬; viral process; positive regulation of autophagosome maturation; response to interferon-gamma; 異種吞噬;
	來源：Amigo / QuickGO
直系同源
	10241
	無數據
	ENSG00000136436
	無數據
	Q13137
	無數據
	NM_001261390; NM_001261391; NM_001261393; NM_001261395; NM_005831
	無數據
	NP_001248319; NP_001248320; NP_001248322; NP_001248324; NP_005822
	無數據
	維基數據
檢視/編輯人類

CALCOCO2（Calcium-binding and coiled-coil domain-containing protein 2，「鈣結合和捲曲螺旋區蛋白2」，也稱為NDP52，nuclear domain protein 52）是人類基因 CALCOCO2 編碼的蛋白質^[3]^[4]，為一種自噬受體^[5]。

另見

CALCOCO1
TAX1BP1（CALCOCO3）

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000136436 – Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Korioth F, Gieffers C, Maul GG, Frey J. Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment. The Journal of Cell Biology. July 1995, 130 (1): 1–13. PMC 2120522 . PMID 7540613. doi:10.1083/jcb.130.1.1.
^ Entrez Gene: CALCOCO2 calcium binding and coiled-coil domain 2. （原始內容存檔於2010-12-05）.
^ Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, et al. A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk. Nature Genetics. December 2022, 55 (1): 54–65. PMC 9839450 . PMID 36543916. doi:10.1038/s41588-022-01261-2 .

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000136436 – Ensembl, May 2017

[2] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7540613-3] Korioth F, Gieffers C, Maul GG, Frey J. Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment. The Journal of Cell Biology. July 1995, 130 (1): 1–13. PMC 2120522 . PMID 7540613. doi:10.1083/jcb.130.1.1.

[entrez-4] Entrez Gene: CALCOCO2 calcium binding and coiled-coil domain 2. （原始內容存檔於2010-12-05）.

[5] Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, et al. A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk. Nature Genetics. December 2022, 55 (1): 54–65. PMC 9839450 . PMID 36543916. doi:10.1038/s41588-022-01261-2 .

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