Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic, being an emerging world health is... more Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic, being an emerging world health issue, has led to the swift development of vaccines. Various lifestyles, health conditions, and behaviours affect the body’s reaction to immunisation. Aim: To evaluate the association of Adverse Effects Following Immunisation (AEFI) with different lifestyles and health patterns. Materials and Methods: A cross-sectional online epidemiological analytical survey in study population across India was carried out in Mumbai, India, from 1st June 2021 to 21st June 2021, using Google form survey. It included a sample of 586 responders. A questionnaire consisting of 26 questions regarding lifestyle habits and AEFIs following COVID-19 vaccine administration was distributed. Questions about lifestyle were obtained using Simple Lifestyle Indicator Questionnaire (SLIQ) which includes questions regarding diet, activity/exercise, alcohol consumption, smoking, and stress. Association between the SLIQ score...
As the COVID-19 pandemic is an emerging healthcare concern, there has been swift vaccine developm... more As the COVID-19 pandemic is an emerging healthcare concern, there has been swift vaccine development with minimal clinical trials questioning its protective efficacy outside of clinical trial conditions. The study aims to analyze the adverse events following immunization (AEFI) with COVID-19 vaccines among the domestic Indian population. It also aimed to evaluate the association between AEFI and demographic characteristics, comorbidities, and type of vaccine. This cross-sectional survey included participants ≥ 18 years of Indian origin for passive reporting of AEFI with COVID-19 vaccination using a questionnaire. The incidence of AEFI was calculated in percentage; the Chi-square test was used to determine associations between AEFI and independent variables. The incidence of reported AEFI was 76.4%. The most frequently reported AEFI was redness [74.38% (n = 328)], followed by pain [52.83% (n = 233)], swelling [52.83% (n = 233)], and fever [50.34% (n = 222)]. The majority of AEFIs wer...
Background: Pranayama, a yogic breathing practice, produces several physiological responses in he... more Background: Pranayama, a yogic breathing practice, produces several physiological responses in healthy individuals. Hypertension is a critical and booming public health challenge all over the world. Yoga is one of the effective methods to reduce blood pressure (BP) and pulse rate (PR). Objective: To evaluate the effect of left nostril breathing (LNB) exercise on cardiorespiratory parameters and reaction time (RT) in young healthy individuals. Materials and methods: In this study, 106 young healthy individuals between 18 and 25 years of age were included. The systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse rate (PR), respiratory rate (RR), vital capacity (VC), peak expiratory flow rate (PEFR), and reaction time (RT) of volunteers were recorded at baseline (before exercise) and after two weeks of left nostril breathing exercise performed 45 minutes daily.
International Journal of Preventive and Clinical Dental Research, 2017
Context: Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) has become on... more Context: Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) has become one of the most serious health issues in the world. However, there exists a mixed attitude among dental professionals and students while treating HIV-infected patients. Aim: To assess HIV/AIDS-related understanding amongst dental students and dental faculty in a dental school located in urban India. Settings and design: Five-hundred respondents were divided into three groups: Group I -Undergraduate Dental Students, Group II -Postgraduate Dental Students, and Group III -Dental Faculty. A questionnaire survey with multiple choice questions was conducted to explore the understanding of dental students and dental faculty in a dental school in urban India, i.e., representative of the Indian dental academia. Pearson chi-square test was used to analyze the responses for different domains (knowledge and awareness, attitude and practice and, adequacy of training) among the different subgroups of respondents. Results: All 500 questionnaires were evaluated after excluding questions with invalid answers. Responses to 12 out of 15 questions showed significant differences (p < 0.001) using Pearson chi-square test. It was found that higher level of training correlated with better knowledge of HIV infection. Considering how early dental students start treating patients clinically, this study points out the need for early incorporation of training in undergraduate dental curricula with emphasis on problem-based learning, especially in the areas of pathogenesis and dental management of HIV-infected/AIDS patients. Dental professionals need to augment their diagnostic skills in this area, by means of continuing dental education.
International journal of scientific research, 2020
Mood is the behavioral and emotional state of mind. It is documented that serotonin is neurotrans... more Mood is the behavioral and emotional state of mind. It is documented that serotonin is neurotransmitter plays a pivotal role in mood regulation and has image feelings of well-being and happiness been studied as mood changer during various responses. The present study was performed to evaluate the relationship between serotonin levels and mood changes among first year medical students. The study revealed that a relationship does indeed exist between serotonin levels and various responses related to mood change and overall feeling of well being. This study hopes that further clinical implications may be done in cases of mood changes and mood disorders by monitoring and treating serotonin deficiency in these patients.
Background: COVID-19 presenting as SARI (severe acute respiratory syndrome) mandates the need for... more Background: COVID-19 presenting as SARI (severe acute respiratory syndrome) mandates the need for ICU (intensive care unit) hospitalization, increasing healthcare burden. This study aims to determine knowledge of healthcare professionals towards management of SARI in COVID-19 suspected cases. Methods: A total of 313 healthcare professionals from the state of Maharashtra, India completed a questionnaire-based survey study adapted from the WHO interim guidance for management of SARI in COVID-19 suspected cases. Convenience sampling method was used and the distribution of responses was presented as frequencies and percentages. Sub-groups were classified on the basis of gender, age, profession and ICU vs. Non-ICU setting. Descriptive statistics were performed for all groups based on percentage of correct responses and individual pairwise comparisons were done using the Chi-Square test. Results: The median and mean percentage of correct responses for all sub groups was only 66.80% and 58...
Introduction : The use of nasal irrigation for the treatment of nose and sinus complaints has its... more Introduction : The use of nasal irrigation for the treatment of nose and sinus complaints has its foundations in yogic and homoeopathic traditions. There has been increasing use of saline irrigation, douches, sprays and rinsing as an adjunct to the medical management of chronic rhinosinusitis. Treatment strategies often include the use of topical saline from once to more than four times a day. After nasal surgery patient may suffer from various complications like nasal congestion, discharge, bleeding etc. So this study was conducted to evaluate the efficacy of Saline Nasal Spray during post-operative nasal surgery like Septoplasty, Polypectomy, Turbinectomy, Dacryocystorrhinostomy (DCR) and Functional Endoscopic Sinus Surgery (FESS). Objectives : The objective of this study was to evaluate the efficacy, safety and tolerability of Saline Nasal spray during post-operative period of nasal surgery. Methods : Forty patients of either sex posted for nasal surgery were enrolled in the stud...
Clinical respiratory physiology, exercise and functional imaging, 2021
Background: This study evaluates the functional capacity and the presence of oxygen (O2) desatura... more Background: This study evaluates the functional capacity and the presence of oxygen (O2) desaturation in post-COVID patients using the 6-minute walk test (6MWT). Methods: 6MWT results of 31 post-COVID patients were assessed. Parameters included 6-minute walking distance (6MWD), minimum (min), maximum (max), baseline, end and mean heart rate (HR), and oxygen saturation (SPO2). Patients were categorized based on age, gender, BMI (WHO criteria), DLCO (diffusing capacity of lungs for carbon monoxide), and cross-tabulations were done with 6MWT parameters. ANOVA was used for the comparison of continuous variables in subgroups , and the chi-square test was used for categorical data. Results: The mean (SD) 6MWD and % predicted (pred) distance (dist) were 321.23 meters (53.51) and 60% (10.37) respectively, and the HR and O2 saturation were 113.64 (12.92) and 95.11% (1.98). O2 desaturation (&lt;95%) was observed in 71% of patients with a mean min SPO2 of 92.58% (3.11) and a mean O2 reduction of 4.53% from baseline. Most patients (96.7%) had a % predicted distance of &lt;75%. About 73% of those who desaturated and 66.7 % with a % pred dist of &lt;75% did not have a pre-existing respiratory illness. Desaturation was common in the age group of &gt;55 years (p&gt;0.05) whereas % pred dist of &lt;75% was more common in the age group of 35-55 years (p&lt;0.05). CT-severity scores of ≥8, presence of spirometry abnormalities with a restrictive pattern, and DLCO reduction were observed in those with desaturation and % pred dist of &lt;75% (p&gt;0.05). WE USE COOKIES ON THIS SITE TO ENHANCE YOUR USER EXPERIENCE By clicking any link on this page you are giving your consent for us to set cookies. OK, I agree No, give me more info Previous Measurements and Main Results: Exercise-induced O2 desaturation (&gt;4%) and functional limitation (reduced 6MWD and % pred dist) were observed in post-COVID patients irrespective of pre-existing respiratory illness.
Background: The aim of the study is to assess the anxiolytic effects of yogic relaxation techniqu... more Background: The aim of the study is to assess the anxiolytic effects of yogic relaxation technique (YRT) in patients requiring root canal treatment (RCT). Materials and Methods: In this prospective, randomized, placebo-controlled study, 30 patients undergoing RCT with baseline visual analog scale for anxiety (VAS-A) of score >4 were divided into Group 1: YRTs; Group 2: alprazolam (0.25 mg/0.5 mg), and Group 3: placebo. After 30 min of completion of YRT, endodontic treatment was performed. Reduction in anxiety was analyzed using state anxiety score (domain) of the state-trait anxiety inventory scale. Results: There was no significant difference in anxiety score 1 h before RCT between groups (P = 0.401). Ten minutes before (P < 0.0001) and after RCT (P < 0.0001), there was significant difference between groups (yogic relaxation vs. alprazolam [P < 0.0001]; yogic relaxation vs. placebo [P < 0.0001]). Ten minutes before RCT, yoga relaxation showed significant difference in anxiety score for pain versus alprazolam and placebo (P < 0.0001 for both). Ten minutes after RCT, the change from baseline in mean anxiety score for pain was significantly different with yogic relaxation (versus alprazolam [P = 0.043]; versus placebo [P = 0.002]). As per the global assessment of efficacy, the response was excellent in 9 (90%), 2 (20%), and 1 (10%) patients in yoga relaxation group, alprazolam group, and placebo group, respectively. Difference in response between three groups was significant (P < 0.0001). There was no significant difference in the global assessment of tolerability between three groups (P = 0.535). No adverse events were reported. Conclusion: Before RCT, YRT is an effective alternative to anxiolytic agents, alprazolam.
National Journal of Physiology, Pharmacy and Pharmacology, 2019
Background: Topical corticosteroids (TC) have a reputation as anti-acne, antiblemish effects and ... more Background: Topical corticosteroids (TC) have a reputation as anti-acne, antiblemish effects and popularly used as fairness creams. In India, there has been a rise in misuse of TC in last10 years. The present study was conducted to analyse the magnitude of adverse effects of topical corticosteroids abuse in dermatology outpatient department of a tertiary care hospital. Methods: A retrospective observational study was conducted on patients after categorizing them as a TC misuser by dermatologists. The socio-demographic data, chief complaints, details of drugs misuse and adverse drug reaction outcome was collected. Results: A total of 1240 patients was screened, out of which 80 patients misused TC without dermatologist prescription for their skin disease. TC was mainly misused by teenagers (43.8%). Misuse of topical corticosteroids was more common among females (76.3%). Betamethasone valerate (72.5%) was most common TC misused. Most common source of advice of TC misuse was friends (37.5%). Most common purpose of TC misuse was acne (55%) followed by cosmetic purposes (21.3%). The most common morphological varieties of adverse drug reactions were burning and itching sensation (53%) followed by increase severity of acne (44%). Conclusions: TC misuse was more common in teenage females. Most common adverse effect reported is burning and itch sensation followed by increase severity of acne. The study data indicates a significance of problem and requirement of urgent measures to control TC misuse.
The rapid and extensive spread of the COVID-19 pandemic has become a major cause of concern for t... more The rapid and extensive spread of the COVID-19 pandemic has become a major cause of concern for the healthcare profession. The aim of this study is to assess the awareness of COVID-19 disease and related infection control practices among healthcare professionals and students in the Mumbai Metropolitan Region.
Ashwagandha is an excellent adaptogen that is being used since ancient times in Ayurvedic medicin... more Ashwagandha is an excellent adaptogen that is being used since ancient times in Ayurvedic medicine. Traditionally, it is used for various ailments and general well-being, including the treatment of geriatric patients. Managing quality of life (QoL) remains a challenge for the elderly population, especially joint pain management, sleep, and general well-being. With a growing global elderly population, QoL management with efficient medication and supplementation is the major healthcare requirement. The objective of this study was to assess the safety, efficacy, and tolerability of Ashwagandha (Withania somnifera (L.) Dunal.) root extract on the improvement of general health and sleep in elderly people. This 12-week, prospective, randomized, double-blind, placebo-controlled study was conducted on individuals of either gender aged between 65-80 years. Participants were randomized to receive Ashwagandha root extract at a dose of 600 mg/day (n = 25) orally, or identical placebo capsules with the same dose (n = 25) for 12 weeks. Efficacy was assessed using the WHOQOL-BREF questionnaire, sleep quality, mental alertness on rising, and Physician's Global Assessment of Efficacy to Therapy (PGAET). The safety and tolerability were assessed using the clinical adverse events reporting and Patient's Global Assessment of Tolerability to Therapy (PGATT). Statistically significant (P<0.0001) improvement was observed in the Ashwagandha treatment group compared to the placebo. The mean (SD) total score of WHOQOL-BREF improved from 140.53 (8.25) at the baseline to 161.84(9.32) at the end of the study. The individual domain scores were also improved. At baseline, the sleep quality and the mental alertness on rising were comparatively low in both the groups. However, upon intervention, a significant increase in the quality of sleep (P<0.0001) and mental alertness (P<0.034) was observed in the Ashwagandha 1 2 3 4
International Journal of Recent Scientific Research, 2017
Objective: To assess the number of Private Dental Practitioners (PDPs) practicing and not practic... more Objective: To assess the number of Private Dental Practitioners (PDPs) practicing and not practicing dental implantology and to evaluate their knowledge, awareness and practice about implant dentistry. Methods: A self-structured questionnaire was distributed to 200 PDPs of Navi Mumbai. The questionnaire covered general basic information and assessed the knowledge, attitude and practice of PDPs regarding implant dentistry. Descriptive analysis was carried out for the responses. Results: Out of 200 PDPs 45% were Bachelor of Dental Surgery(BDS) and most of them were not practicing implant dentistry due to lack of skills, while 55% were Master of Dental Surgery (MDS) in various fields and were practicing implant dentistry by themselves. High cost of implant dentistry and fear of surgery was the main hindrance in convincing the patients for dental implants. Most of the PDPs would like to update their knowledge regarding implant dentistry through Continuing Dental Education (CDE) programs. Conclusion: Though dental implants have changed the outlook of dentistry in last few decades, the knowledge and practice of dental implants by PDPs in Navi Mumbai is still limited. Various courses and CDE programs can help PDPs to update their knowledge and skill regarding implant dentistry.
The gingival biotype is of utmost importance for esthetics and biologic function. Anatomical char... more The gingival biotype is of utmost importance for esthetics and biologic function. Anatomical characteristic of periodontium such as gingival thickness (GT), width of keratinized gingiva, and alveolar bone morphology will determine the behavior of periodontium when subjected to physical, chemical, or bacterial insult or during therapeutic procedure. The aim of this study was to correlate the GT with gingival width (GW), probing depth (PD), and papillary fill (PF) in relation to maxillary anterior region. Undergraduate dental students and interns from a dental college in Navi Mumbai were enrolled in the study according to the inclusion criteria. Six teeth per subject were assessed; a total of 2178 maxillary anterior teeth were examined. Subjects were examined clinically for GT, width of keratinized gingiva, pocket depth, and interdental PF. The data obtained was tabulated and subjected to statistical analysis. Spearman's correlation analysis test was performed to find the correlat...
Journal of the International Society of Sports Nutrition, 2015
Withania somnifera (ashwagandha) is a prominent herb in Ayurveda. This study was conducted to exa... more Withania somnifera (ashwagandha) is a prominent herb in Ayurveda. This study was conducted to examine the possible effects of ashwagandha root extract consumption on muscle mass and strength in healthy young men engaged in resistance training. In this 8-week, randomized, prospective, double-blind, placebo-controlled clinical study, 57 young male subjects (18-50 years old) with little experience in resistance training were randomized into treatment (29 subjects) and placebo (28 subjects) groups. Subjects in the treatment group consumed 300 mg of ashwagandha root extract twice daily, while the control group consumed starch placebos. Following baseline measurements, both groups of subjects underwent resistance training for 8 weeks and measurements were repeated at the end of week 8. The primary efficacy measure was muscle strength. The secondary efficacy measures were muscle size, body composition, serum testosterone levels and muscle recovery. Muscle strength was evaluated using the 1...
Background.Many women experience sexual dysfunction where there are orgasm disorders and sexual d... more Background.Many women experience sexual dysfunction where there are orgasm disorders and sexual difficulties. Ashwagandha (Withania somnifera) is a herb known to improve the body’s physical and psychological condition.Objective.The purpose of the study was to determine the efficacy and safety of a high-concentration ashwagandha root extract (HCARE) supplementation for improving sexual function in healthy females.Methods.In this pilot study, 50 study subjects were randomized to either (i) HCARE-treated group or (ii) placebo- (starch-) treated group. The subjects consumed either HCARE or placebo capsules of 300mg twice daily for 8 weeks. Sexual function was assessed using two psychometric scales, the Female Sexual Function Index (FSFI) Questionnaire and the Female Sexual Distress Scale (FSDS), and by the number of total and successful sexual encounters.Results.The analysis indicates that treatment with HCARE leads to significantly higher improvement, relative to placebo, in the FSFI T...
Remineralization as a treatment procedure has received much attention from clinicians. The object... more Remineralization as a treatment procedure has received much attention from clinicians. The objective of this in vitro study was to find out the efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF), and tricalcium phosphate fluoride (TCP-F) in remineralizing enamel surface on which artificial caries lesion had been created. The changes were analyzed using DIAGNOdent(®) (KaVo) and scanning electron microscope (SEM). A total of 52 premolars and 24 molars were selected and classified into four groups of 13 premolars and 6 molars in each: I (CPP-ACP), II (CPP-ACPF), III (TCP-F), and IV (artificial saliva). All the samples were assessed using DIAGNOdent at the baseline and after demineralization and remineralization. Ten samples were randomly selected from each group baseline after demineralization and after remineralization for surface evaluation using SEM. Statistical analysis showed that all the experimental groups had a significantly higher amount of remineralization except for group IV. All the three experimental groups showed a statistically significant amount of remineralization. However, because of the added benefit of fluoride (NaF 0.2%), CPP-ACPF (Tooth Mousse-Plus(®)) and TCP-F showed marginally more amount of remineralization than did CPP-ACP (Tooth Mousse(®)). Remineralization efficacy was TCP-F &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; CPP-ACPF &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; CPP-ACP.
Objectives: Objectives: Objectives: Objectives: To study, the anticataract activity of lisinopril... more Objectives: Objectives: Objectives: Objectives: To study, the anticataract activity of lisinopril and enalapril on cataract in-Grant Medical College, duced by glucose, in goat lenses. Mumbai, Materials and Methods: Materials and Methods: Materials and Methods: Materials and Methods: Materials and Methods: Goat lenses were incubated in artificial aqueous humor contain *Ranbaxy Laboratories Ltd., **Department of Biochemistry, ing 55 mM glucose (cataractogenesis) with lisinopril or enalapril in different concentrations B.J. Medical College, Pune, at room temperature for 72 h. Biochemical parameters studied in the lens were electrolytes ***Department of (Na + , K + ), Na + -K + -ATPase activity, malondialdehyde (MDA) and proteins. Pharmacology, B.J. Medical Results: Results: Results: Results: Results: Glucose induced opacification of goat lens began 8-10 hrs after incubation and College, Pune. was complete in 72-80 hrs. Cataractous lenses showed higher Na + , MDA (P<0.001), lower Na + -K + -ATPase activity, and water-soluble protein content. Lenses treated with lisinopril or
Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic, being an emerging world health is... more Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic, being an emerging world health issue, has led to the swift development of vaccines. Various lifestyles, health conditions, and behaviours affect the body’s reaction to immunisation. Aim: To evaluate the association of Adverse Effects Following Immunisation (AEFI) with different lifestyles and health patterns. Materials and Methods: A cross-sectional online epidemiological analytical survey in study population across India was carried out in Mumbai, India, from 1st June 2021 to 21st June 2021, using Google form survey. It included a sample of 586 responders. A questionnaire consisting of 26 questions regarding lifestyle habits and AEFIs following COVID-19 vaccine administration was distributed. Questions about lifestyle were obtained using Simple Lifestyle Indicator Questionnaire (SLIQ) which includes questions regarding diet, activity/exercise, alcohol consumption, smoking, and stress. Association between the SLIQ score...
As the COVID-19 pandemic is an emerging healthcare concern, there has been swift vaccine developm... more As the COVID-19 pandemic is an emerging healthcare concern, there has been swift vaccine development with minimal clinical trials questioning its protective efficacy outside of clinical trial conditions. The study aims to analyze the adverse events following immunization (AEFI) with COVID-19 vaccines among the domestic Indian population. It also aimed to evaluate the association between AEFI and demographic characteristics, comorbidities, and type of vaccine. This cross-sectional survey included participants ≥ 18 years of Indian origin for passive reporting of AEFI with COVID-19 vaccination using a questionnaire. The incidence of AEFI was calculated in percentage; the Chi-square test was used to determine associations between AEFI and independent variables. The incidence of reported AEFI was 76.4%. The most frequently reported AEFI was redness [74.38% (n = 328)], followed by pain [52.83% (n = 233)], swelling [52.83% (n = 233)], and fever [50.34% (n = 222)]. The majority of AEFIs wer...
Background: Pranayama, a yogic breathing practice, produces several physiological responses in he... more Background: Pranayama, a yogic breathing practice, produces several physiological responses in healthy individuals. Hypertension is a critical and booming public health challenge all over the world. Yoga is one of the effective methods to reduce blood pressure (BP) and pulse rate (PR). Objective: To evaluate the effect of left nostril breathing (LNB) exercise on cardiorespiratory parameters and reaction time (RT) in young healthy individuals. Materials and methods: In this study, 106 young healthy individuals between 18 and 25 years of age were included. The systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse rate (PR), respiratory rate (RR), vital capacity (VC), peak expiratory flow rate (PEFR), and reaction time (RT) of volunteers were recorded at baseline (before exercise) and after two weeks of left nostril breathing exercise performed 45 minutes daily.
International Journal of Preventive and Clinical Dental Research, 2017
Context: Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) has become on... more Context: Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) has become one of the most serious health issues in the world. However, there exists a mixed attitude among dental professionals and students while treating HIV-infected patients. Aim: To assess HIV/AIDS-related understanding amongst dental students and dental faculty in a dental school located in urban India. Settings and design: Five-hundred respondents were divided into three groups: Group I -Undergraduate Dental Students, Group II -Postgraduate Dental Students, and Group III -Dental Faculty. A questionnaire survey with multiple choice questions was conducted to explore the understanding of dental students and dental faculty in a dental school in urban India, i.e., representative of the Indian dental academia. Pearson chi-square test was used to analyze the responses for different domains (knowledge and awareness, attitude and practice and, adequacy of training) among the different subgroups of respondents. Results: All 500 questionnaires were evaluated after excluding questions with invalid answers. Responses to 12 out of 15 questions showed significant differences (p < 0.001) using Pearson chi-square test. It was found that higher level of training correlated with better knowledge of HIV infection. Considering how early dental students start treating patients clinically, this study points out the need for early incorporation of training in undergraduate dental curricula with emphasis on problem-based learning, especially in the areas of pathogenesis and dental management of HIV-infected/AIDS patients. Dental professionals need to augment their diagnostic skills in this area, by means of continuing dental education.
International journal of scientific research, 2020
Mood is the behavioral and emotional state of mind. It is documented that serotonin is neurotrans... more Mood is the behavioral and emotional state of mind. It is documented that serotonin is neurotransmitter plays a pivotal role in mood regulation and has image feelings of well-being and happiness been studied as mood changer during various responses. The present study was performed to evaluate the relationship between serotonin levels and mood changes among first year medical students. The study revealed that a relationship does indeed exist between serotonin levels and various responses related to mood change and overall feeling of well being. This study hopes that further clinical implications may be done in cases of mood changes and mood disorders by monitoring and treating serotonin deficiency in these patients.
Background: COVID-19 presenting as SARI (severe acute respiratory syndrome) mandates the need for... more Background: COVID-19 presenting as SARI (severe acute respiratory syndrome) mandates the need for ICU (intensive care unit) hospitalization, increasing healthcare burden. This study aims to determine knowledge of healthcare professionals towards management of SARI in COVID-19 suspected cases. Methods: A total of 313 healthcare professionals from the state of Maharashtra, India completed a questionnaire-based survey study adapted from the WHO interim guidance for management of SARI in COVID-19 suspected cases. Convenience sampling method was used and the distribution of responses was presented as frequencies and percentages. Sub-groups were classified on the basis of gender, age, profession and ICU vs. Non-ICU setting. Descriptive statistics were performed for all groups based on percentage of correct responses and individual pairwise comparisons were done using the Chi-Square test. Results: The median and mean percentage of correct responses for all sub groups was only 66.80% and 58...
Introduction : The use of nasal irrigation for the treatment of nose and sinus complaints has its... more Introduction : The use of nasal irrigation for the treatment of nose and sinus complaints has its foundations in yogic and homoeopathic traditions. There has been increasing use of saline irrigation, douches, sprays and rinsing as an adjunct to the medical management of chronic rhinosinusitis. Treatment strategies often include the use of topical saline from once to more than four times a day. After nasal surgery patient may suffer from various complications like nasal congestion, discharge, bleeding etc. So this study was conducted to evaluate the efficacy of Saline Nasal Spray during post-operative nasal surgery like Septoplasty, Polypectomy, Turbinectomy, Dacryocystorrhinostomy (DCR) and Functional Endoscopic Sinus Surgery (FESS). Objectives : The objective of this study was to evaluate the efficacy, safety and tolerability of Saline Nasal spray during post-operative period of nasal surgery. Methods : Forty patients of either sex posted for nasal surgery were enrolled in the stud...
Clinical respiratory physiology, exercise and functional imaging, 2021
Background: This study evaluates the functional capacity and the presence of oxygen (O2) desatura... more Background: This study evaluates the functional capacity and the presence of oxygen (O2) desaturation in post-COVID patients using the 6-minute walk test (6MWT). Methods: 6MWT results of 31 post-COVID patients were assessed. Parameters included 6-minute walking distance (6MWD), minimum (min), maximum (max), baseline, end and mean heart rate (HR), and oxygen saturation (SPO2). Patients were categorized based on age, gender, BMI (WHO criteria), DLCO (diffusing capacity of lungs for carbon monoxide), and cross-tabulations were done with 6MWT parameters. ANOVA was used for the comparison of continuous variables in subgroups , and the chi-square test was used for categorical data. Results: The mean (SD) 6MWD and % predicted (pred) distance (dist) were 321.23 meters (53.51) and 60% (10.37) respectively, and the HR and O2 saturation were 113.64 (12.92) and 95.11% (1.98). O2 desaturation (&lt;95%) was observed in 71% of patients with a mean min SPO2 of 92.58% (3.11) and a mean O2 reduction of 4.53% from baseline. Most patients (96.7%) had a % predicted distance of &lt;75%. About 73% of those who desaturated and 66.7 % with a % pred dist of &lt;75% did not have a pre-existing respiratory illness. Desaturation was common in the age group of &gt;55 years (p&gt;0.05) whereas % pred dist of &lt;75% was more common in the age group of 35-55 years (p&lt;0.05). CT-severity scores of ≥8, presence of spirometry abnormalities with a restrictive pattern, and DLCO reduction were observed in those with desaturation and % pred dist of &lt;75% (p&gt;0.05). WE USE COOKIES ON THIS SITE TO ENHANCE YOUR USER EXPERIENCE By clicking any link on this page you are giving your consent for us to set cookies. OK, I agree No, give me more info Previous Measurements and Main Results: Exercise-induced O2 desaturation (&gt;4%) and functional limitation (reduced 6MWD and % pred dist) were observed in post-COVID patients irrespective of pre-existing respiratory illness.
Background: The aim of the study is to assess the anxiolytic effects of yogic relaxation techniqu... more Background: The aim of the study is to assess the anxiolytic effects of yogic relaxation technique (YRT) in patients requiring root canal treatment (RCT). Materials and Methods: In this prospective, randomized, placebo-controlled study, 30 patients undergoing RCT with baseline visual analog scale for anxiety (VAS-A) of score >4 were divided into Group 1: YRTs; Group 2: alprazolam (0.25 mg/0.5 mg), and Group 3: placebo. After 30 min of completion of YRT, endodontic treatment was performed. Reduction in anxiety was analyzed using state anxiety score (domain) of the state-trait anxiety inventory scale. Results: There was no significant difference in anxiety score 1 h before RCT between groups (P = 0.401). Ten minutes before (P < 0.0001) and after RCT (P < 0.0001), there was significant difference between groups (yogic relaxation vs. alprazolam [P < 0.0001]; yogic relaxation vs. placebo [P < 0.0001]). Ten minutes before RCT, yoga relaxation showed significant difference in anxiety score for pain versus alprazolam and placebo (P < 0.0001 for both). Ten minutes after RCT, the change from baseline in mean anxiety score for pain was significantly different with yogic relaxation (versus alprazolam [P = 0.043]; versus placebo [P = 0.002]). As per the global assessment of efficacy, the response was excellent in 9 (90%), 2 (20%), and 1 (10%) patients in yoga relaxation group, alprazolam group, and placebo group, respectively. Difference in response between three groups was significant (P < 0.0001). There was no significant difference in the global assessment of tolerability between three groups (P = 0.535). No adverse events were reported. Conclusion: Before RCT, YRT is an effective alternative to anxiolytic agents, alprazolam.
National Journal of Physiology, Pharmacy and Pharmacology, 2019
Background: Topical corticosteroids (TC) have a reputation as anti-acne, antiblemish effects and ... more Background: Topical corticosteroids (TC) have a reputation as anti-acne, antiblemish effects and popularly used as fairness creams. In India, there has been a rise in misuse of TC in last10 years. The present study was conducted to analyse the magnitude of adverse effects of topical corticosteroids abuse in dermatology outpatient department of a tertiary care hospital. Methods: A retrospective observational study was conducted on patients after categorizing them as a TC misuser by dermatologists. The socio-demographic data, chief complaints, details of drugs misuse and adverse drug reaction outcome was collected. Results: A total of 1240 patients was screened, out of which 80 patients misused TC without dermatologist prescription for their skin disease. TC was mainly misused by teenagers (43.8%). Misuse of topical corticosteroids was more common among females (76.3%). Betamethasone valerate (72.5%) was most common TC misused. Most common source of advice of TC misuse was friends (37.5%). Most common purpose of TC misuse was acne (55%) followed by cosmetic purposes (21.3%). The most common morphological varieties of adverse drug reactions were burning and itching sensation (53%) followed by increase severity of acne (44%). Conclusions: TC misuse was more common in teenage females. Most common adverse effect reported is burning and itch sensation followed by increase severity of acne. The study data indicates a significance of problem and requirement of urgent measures to control TC misuse.
The rapid and extensive spread of the COVID-19 pandemic has become a major cause of concern for t... more The rapid and extensive spread of the COVID-19 pandemic has become a major cause of concern for the healthcare profession. The aim of this study is to assess the awareness of COVID-19 disease and related infection control practices among healthcare professionals and students in the Mumbai Metropolitan Region.
Ashwagandha is an excellent adaptogen that is being used since ancient times in Ayurvedic medicin... more Ashwagandha is an excellent adaptogen that is being used since ancient times in Ayurvedic medicine. Traditionally, it is used for various ailments and general well-being, including the treatment of geriatric patients. Managing quality of life (QoL) remains a challenge for the elderly population, especially joint pain management, sleep, and general well-being. With a growing global elderly population, QoL management with efficient medication and supplementation is the major healthcare requirement. The objective of this study was to assess the safety, efficacy, and tolerability of Ashwagandha (Withania somnifera (L.) Dunal.) root extract on the improvement of general health and sleep in elderly people. This 12-week, prospective, randomized, double-blind, placebo-controlled study was conducted on individuals of either gender aged between 65-80 years. Participants were randomized to receive Ashwagandha root extract at a dose of 600 mg/day (n = 25) orally, or identical placebo capsules with the same dose (n = 25) for 12 weeks. Efficacy was assessed using the WHOQOL-BREF questionnaire, sleep quality, mental alertness on rising, and Physician's Global Assessment of Efficacy to Therapy (PGAET). The safety and tolerability were assessed using the clinical adverse events reporting and Patient's Global Assessment of Tolerability to Therapy (PGATT). Statistically significant (P<0.0001) improvement was observed in the Ashwagandha treatment group compared to the placebo. The mean (SD) total score of WHOQOL-BREF improved from 140.53 (8.25) at the baseline to 161.84(9.32) at the end of the study. The individual domain scores were also improved. At baseline, the sleep quality and the mental alertness on rising were comparatively low in both the groups. However, upon intervention, a significant increase in the quality of sleep (P<0.0001) and mental alertness (P<0.034) was observed in the Ashwagandha 1 2 3 4
International Journal of Recent Scientific Research, 2017
Objective: To assess the number of Private Dental Practitioners (PDPs) practicing and not practic... more Objective: To assess the number of Private Dental Practitioners (PDPs) practicing and not practicing dental implantology and to evaluate their knowledge, awareness and practice about implant dentistry. Methods: A self-structured questionnaire was distributed to 200 PDPs of Navi Mumbai. The questionnaire covered general basic information and assessed the knowledge, attitude and practice of PDPs regarding implant dentistry. Descriptive analysis was carried out for the responses. Results: Out of 200 PDPs 45% were Bachelor of Dental Surgery(BDS) and most of them were not practicing implant dentistry due to lack of skills, while 55% were Master of Dental Surgery (MDS) in various fields and were practicing implant dentistry by themselves. High cost of implant dentistry and fear of surgery was the main hindrance in convincing the patients for dental implants. Most of the PDPs would like to update their knowledge regarding implant dentistry through Continuing Dental Education (CDE) programs. Conclusion: Though dental implants have changed the outlook of dentistry in last few decades, the knowledge and practice of dental implants by PDPs in Navi Mumbai is still limited. Various courses and CDE programs can help PDPs to update their knowledge and skill regarding implant dentistry.
The gingival biotype is of utmost importance for esthetics and biologic function. Anatomical char... more The gingival biotype is of utmost importance for esthetics and biologic function. Anatomical characteristic of periodontium such as gingival thickness (GT), width of keratinized gingiva, and alveolar bone morphology will determine the behavior of periodontium when subjected to physical, chemical, or bacterial insult or during therapeutic procedure. The aim of this study was to correlate the GT with gingival width (GW), probing depth (PD), and papillary fill (PF) in relation to maxillary anterior region. Undergraduate dental students and interns from a dental college in Navi Mumbai were enrolled in the study according to the inclusion criteria. Six teeth per subject were assessed; a total of 2178 maxillary anterior teeth were examined. Subjects were examined clinically for GT, width of keratinized gingiva, pocket depth, and interdental PF. The data obtained was tabulated and subjected to statistical analysis. Spearman's correlation analysis test was performed to find the correlat...
Journal of the International Society of Sports Nutrition, 2015
Withania somnifera (ashwagandha) is a prominent herb in Ayurveda. This study was conducted to exa... more Withania somnifera (ashwagandha) is a prominent herb in Ayurveda. This study was conducted to examine the possible effects of ashwagandha root extract consumption on muscle mass and strength in healthy young men engaged in resistance training. In this 8-week, randomized, prospective, double-blind, placebo-controlled clinical study, 57 young male subjects (18-50 years old) with little experience in resistance training were randomized into treatment (29 subjects) and placebo (28 subjects) groups. Subjects in the treatment group consumed 300 mg of ashwagandha root extract twice daily, while the control group consumed starch placebos. Following baseline measurements, both groups of subjects underwent resistance training for 8 weeks and measurements were repeated at the end of week 8. The primary efficacy measure was muscle strength. The secondary efficacy measures were muscle size, body composition, serum testosterone levels and muscle recovery. Muscle strength was evaluated using the 1...
Background.Many women experience sexual dysfunction where there are orgasm disorders and sexual d... more Background.Many women experience sexual dysfunction where there are orgasm disorders and sexual difficulties. Ashwagandha (Withania somnifera) is a herb known to improve the body’s physical and psychological condition.Objective.The purpose of the study was to determine the efficacy and safety of a high-concentration ashwagandha root extract (HCARE) supplementation for improving sexual function in healthy females.Methods.In this pilot study, 50 study subjects were randomized to either (i) HCARE-treated group or (ii) placebo- (starch-) treated group. The subjects consumed either HCARE or placebo capsules of 300mg twice daily for 8 weeks. Sexual function was assessed using two psychometric scales, the Female Sexual Function Index (FSFI) Questionnaire and the Female Sexual Distress Scale (FSDS), and by the number of total and successful sexual encounters.Results.The analysis indicates that treatment with HCARE leads to significantly higher improvement, relative to placebo, in the FSFI T...
Remineralization as a treatment procedure has received much attention from clinicians. The object... more Remineralization as a treatment procedure has received much attention from clinicians. The objective of this in vitro study was to find out the efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF), and tricalcium phosphate fluoride (TCP-F) in remineralizing enamel surface on which artificial caries lesion had been created. The changes were analyzed using DIAGNOdent(®) (KaVo) and scanning electron microscope (SEM). A total of 52 premolars and 24 molars were selected and classified into four groups of 13 premolars and 6 molars in each: I (CPP-ACP), II (CPP-ACPF), III (TCP-F), and IV (artificial saliva). All the samples were assessed using DIAGNOdent at the baseline and after demineralization and remineralization. Ten samples were randomly selected from each group baseline after demineralization and after remineralization for surface evaluation using SEM. Statistical analysis showed that all the experimental groups had a significantly higher amount of remineralization except for group IV. All the three experimental groups showed a statistically significant amount of remineralization. However, because of the added benefit of fluoride (NaF 0.2%), CPP-ACPF (Tooth Mousse-Plus(®)) and TCP-F showed marginally more amount of remineralization than did CPP-ACP (Tooth Mousse(®)). Remineralization efficacy was TCP-F &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; CPP-ACPF &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; CPP-ACP.
Objectives: Objectives: Objectives: Objectives: To study, the anticataract activity of lisinopril... more Objectives: Objectives: Objectives: Objectives: To study, the anticataract activity of lisinopril and enalapril on cataract in-Grant Medical College, duced by glucose, in goat lenses. Mumbai, Materials and Methods: Materials and Methods: Materials and Methods: Materials and Methods: Materials and Methods: Goat lenses were incubated in artificial aqueous humor contain *Ranbaxy Laboratories Ltd., **Department of Biochemistry, ing 55 mM glucose (cataractogenesis) with lisinopril or enalapril in different concentrations B.J. Medical College, Pune, at room temperature for 72 h. Biochemical parameters studied in the lens were electrolytes ***Department of (Na + , K + ), Na + -K + -ATPase activity, malondialdehyde (MDA) and proteins. Pharmacology, B.J. Medical Results: Results: Results: Results: Results: Glucose induced opacification of goat lens began 8-10 hrs after incubation and College, Pune. was complete in 72-80 hrs. Cataractous lenses showed higher Na + , MDA (P<0.001), lower Na + -K + -ATPase activity, and water-soluble protein content. Lenses treated with lisinopril or
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