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Sam Sinai
2,069 posts
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Sam Sinai
@samsinai
Co-founder and Head of Machine Learning @Dyno_Tx. Previously CompBio @Harvard + CS/AI @MIT. Tweets are my own views/interests.
Brooklyn, NY
samsinai.github.io
Joined July 2010
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  • Pinned
    user avatar
    Sam Sinai
    @samsinai
    Oct 26, 2023
    🧵Excited to share that we @Dyno_Tx have launched our 2nd product Dyno eCap 1, a generative AI designed protein validated extensively in nonhuman primates, as a breakthrough capsid with potential to solve the delivery challenge for variety of eye diseases.
    Dyno eCap 1 Capsid - Dyno Therapeutics
    From products.dynotx.com
    24K
  • user avatar
    Sam Sinai
    @samsinai
    Jan 4, 2020
    1/ Dear friends (and P.I.s), in these volatile times, do spare a thought for students of Iranian origin, especially those studying in the US. The past decade was devastating for most of us who had close ties to Iran, no matter what political background we came from.
  • user avatar
    Sam Sinai
    @samsinai
    Dec 15, 2023
    For people who are not in the weeds of ML this might be entertaining. The best paper award for this years NeurIPS went to this paper (which I love) that showed claims of emergence in LLMs are nonsensical.
    arXiv logo
    arxiv.org
    Are Emergent Abilities of Large Language Models a Mirage?
    Recent work claims that large language models display emergent abilities, abilities not present in smaller-scale models that are present in larger-scale models. What makes emergent abilities...
    75K
  • user avatar
    Sam Sinai
    @samsinai
    Jun 7, 2024
    I knew @thephysicsgirl in college. As evident from her public work, she is an incredibly capable person and intrinsically positive and joyful. She is also great at spreading enthusiasm and knowledge. It is so upsetting to see her struggle like this, and see #LongCOVID rob her
    user avatar
    Dianna Cowern
    @thephysicsgirl
    Jun 6, 2024
    From Kyle, Dianna’s husband: Two years ago, I married my smart, adventurous, curious best friend. I loved her curiosity and so did her 3M+ followers on her Science YouTube channel. Now, she’s been 100% bedbound with long Covid for 1.5 years. She lays in a dark room, earplugs
    22K
  • user avatar
    Sam Sinai
    @samsinai
    Feb 11, 2021
    1/ [Long! Tweetorial] I'm excited to finally share the result of the largest project of my PhD. Together w the paper we published a year ago, this paper helped serve as a proof-of-concept for starting @Dyno_Tx. 
    Content cover image
    Deep diversification of an AAV capsid protein by machine learning
    From nature.com
  • user avatar
    Sam Sinai
    @samsinai
    Aug 15, 2021
    My heart goes out to the Afghan people, especially women. I grew up in Iran where many Afghan refugees find (inadequate) asylum. Have played soccer with Afghan boys who kicked ass playing on pebbles without even having shoes. 🧵
  • user avatar
    Sam Sinai
    @samsinai
    Oct 19, 2020
    1/I'm excited to share some of our work related to model-guided sequence design. Firstly I want to introduce FLEXS, a sandbox that lets you play with (and implement your own) sequence design algorithms against other benchmarks.
    GitHub - samsinai/FLEXS: Fitness landscape exploration sandbox for biological sequence design.
    From github.com
  • user avatar
    Sam Sinai
    @samsinai
    Apr 6, 2022
    The pleasure of helping someone else succeed is underrated.
  • user avatar
    Sam Sinai
    @samsinai
    May 6, 2021
    Excited for this new chapter.
    user avatar
    Dyno Therapeutics, Inc.
    @Dyno_Tx
    May 6, 2021
    Dyno Therapeutics Closes $100 Million Series A Financing Led by Andreessen Horowitz to Accelerate AI‑powered Gene Therapy Platform. dynotx.com/dyno-closes-10…
  • user avatar
    Sam Sinai
    @samsinai
    May 9, 2024
    On behalf of @Dyno_Tx's ML team, we are so excited for the work we are going to do with @NVIDIAAI. Special thanks to @ReneeYao1 , @anthonycosta (among many others), and of course the visionary Jensen Huang who sees the size of the opportunity at the intersection of #AI and
    user avatar
    Dyno Therapeutics, Inc.
    @Dyno_Tx
    May 9, 2024
    We're excited to announce our collaboration with @nvidia. Working with the world’s leading computing company and building within NVIDIA's BioNeMo will accelerate Dyno's AI-powered sequence design and bring us all closer to helping patients with transformative new medicines.
    24K
  • user avatar
    Sam Sinai
    @samsinai
    Dec 17, 2020
    Water being transparent is about evolution, not really water's chemistry. Eyes are sensors that are designed to work under water, it's not a coincidence (not that the tweet necessarily implies that).
    user avatar
    Brian Skinner
    @gravity_levity
    Dec 16, 2020
    Replying to @gravity_levity
    Also, water is essentially opaque to all light except a narrow band of wavelengths that happens to correspond to the ones used by our eyes (shown in yellow)
  • user avatar
    Sam Sinai
    @samsinai
    May 11, 2022
    1/ My high school biology teacher, #farhad_meysami, now a civil rights activist, is currently on the 4th day of dry hunger strike in prison, to save another political prisoner’s life. #فرهاد_میثمی
  • user avatar
    Sam Sinai
    @samsinai
    Sep 17, 2018
    Iran and US trade jabs at International atomic energy agency (IAEA) meeting. Of note, the Iranian delegate, Salehi, has a PhD in nuclear science from MIT, the Trump admin's delegate, Secretary Perry, has a B.S. in husbandry. This is embarrassing.
  • user avatar
    Sam Sinai
    @samsinai
    Sep 21, 2022
    The UN is hosting a speech by the Iranian president (who famously oversaw 1000s of extrajudicial executions of political prisoners). Meanwhile the women's movement in Iran, protesting the killing of #MahsaAmini by the police for "lack of proper coverage" is being brutally crushed