Our July issue is live!
nature.com/nchembio/volum…
The cover image illustrates a nanobody stabilizing a formerly misfolded CFTR chloride channel, thereby enabling functional recovery
A new paper from Brian Kuhlman and @BowersRangers used computational protein design to place a substrate recruitment domain adjacent to an active site increasing the specificity of a promiscuous enzyme by 1000-fold. Free to read: rdcu.be/c1tzanature.com/articles/s4158…
A new paper from @JaffreyLab reveals that phospholipids can partition into protein condensates depending on the length of their acyl moiety and influence the properties of the condensates. Free to read link at rdcu.be/drmNe
The Tan and Scheinberg laboratories from @sloan_kettering report SEAKER, an approach that equips CAR-T cells to express enzymes that release prodrugs at tumor sites. Free to read: rdcu.be/cD6GRnature.com/articles/s4158…
A new paper from @CarolynBertozzi and colleagues developed an αHER2 antibody-neuraminidase conjugate that targets sialic acid removal on breast cancer cell surfaces and enhances tumor cell killing by the host immune system. nature.com/articles/s4158…
What if we could have bespoke proteases to cleave any chosen target sequence? @davidrliu and colleagues are getting closer to that dream: they've shown in @ScienceMagazine how to evolve botulinum neurotoxin proteases with altered cleavage specificities. science.sciencemag.org/content/371/65…
Work from the Woo laboratory (@drcmwoo) developed split O-GlcNAcase proteins fused with nanobodies to target the selective removal of O-GlcNAc protein modifications. Free to read at rdcu.be/cgplp. nature.com/articles/s4158…
A new paper from @erblabs, @Chrizzly_92, @eventuallyptrck enabled a 54-step in vitro biosynthesis of the macrolide backbone of the antibiotic erythromycin from CO2. Open access:
A new paper from Jack Taunton and colleagues developed salicylaldehyde-based chemical probes that reversibly and covalently modify the catalytic lysine of protein kinases, with sustained occupancy in cells and animals. Free to read: rdcu.be/cNVx8nature.com/articles/s4158…