Lydia Finley (@lydfinley) / X

Lydia Finley

1,256 posts

Lydia Finley

@lydfinley

Cell biologist with an interest in pretty much everything

Joined March 2017

Lydia Finley
@lydfinley
Mar 9, 2022
Our new work describing a “non-canonical” TCA cycle that is engaged in a cell-state dependent manner is out today in @Nature nature.com/articles/s4158…. Congratulations to lead authors @paigearnold2 @__btjackson @GSKGradSchool @MSKCancerCenter. A few highlights:
A non-canonical tricarboxylic acid cycle underlies cellular identity
From nature.com
Lydia Finley
@lydfinley
Dec 26, 2022
Do you ❤️ the TCA cycle? (trick question). Our new review discusses the origins, discovery, and many functions of the mammalian TCA cycle. By @paigearnold2 @SKI_CellBiology out now in @jbiolchem jbc.org/article/S0021-…
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Lydia Finley
@lydfinley
Jun 22, 2022
Pretty wild: cancer cells more likely to spread during sleep (!) nature.com/articles/s4158… Interesting and dramatic example of how physiology intersects with fundamental cell biology-- here, circadian hormone rhythms and intravasation
The metastatic spread of breast cancer accelerates during sleep
From nature.com
Lydia Finley
@lydfinley
Feb 12, 2025
Things I wish more people knew about doing science in the US (thread):
102K
Lydia Finley
@lydfinley
Feb 28, 2023
What is cancer metabolism? My ❤️letter to the field surveys how metabolic networks support cell functions, key papers in the field, and a call to study normal cell metabolism, too @CellCellPress @MSKCancerCenter
What is cancer metabolism?
From cell.com
104K
Lydia Finley
@lydfinley
Mar 9, 2022
Back by popular demand: our follow-the emoji TCA cycle, v2.0
Lydia Finley
@lydfinley
Sep 18, 2019
Our work identifying alpha-ketoglutarate as an effector of p53-mediated tumor suppression, the result of a fantastic collaboration with Scott Lowe’s lab @SloanKettering, is out today in @Nature! nature.com/articles/s4158… /n
Lydia Finley
@lydfinley
Oct 9, 2019
This is my opus.
Lydia Finley
@lydfinley
May 25, 2020
Our latest work @sloan_kettering, which illustrates how the metabolic profile of stem cells dictates their ability to form a neoplasm, is out today in @NatureCellBio! nature.com/articles/s4155… 1/n
Extracellular serine controls epidermal stem cell fate and tumour initiation
From nature.com
Lydia Finley
@lydfinley
May 18, 2022
Why do only a subset of cancer cells metastasize? Happy to highlight in @NatureNV with @s__baksh beautiful new work from @fendtlab showing how heterogeneous PHGDH expression in cancer cells underlies variable propensity for metastasis: nature.com/articles/d4158…
Lydia Finley
@lydfinley
Feb 1, 2022
How do cells cope with transient disruption in nutrient supply? Work from the Overholtzer lab shows lysosomes store amino acids, helping sustain protein synthesis during starvation. So much to learn about how nutrients are trafficked through the cell!
pnas.org
Leucine retention in lysosomes is regulated by starvation | PNAS
Cells acquire essential nutrients from the environment and utilize adaptive mechanisms to survive when nutrients are scarce. How nutrients are traf...
Lydia Finley
@lydfinley
Apr 28, 2025
Our latest work, led by @__btjackson and Angela Montero @MSKCancerCenter demonstrates how intracellular metabolic gradients induce dependence on exogenous pyruvate in embryonic stem cells
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Lydia Finley
@lydfinley
Feb 23, 2023
Come join us tomorrow for an amazing day of science @MSKCancerCenter celebrating Craig Thompson and his continually pioneering work that got us all to ❤️ metabolism. For the alums: what paper made you join his lab? For me...
67K
Lydia Finley
@lydfinley
Nov 17, 2022
Hi twitter! We are excited to share our very first preprint! Led by Pavlina Todorova, we show that it’s not just what nutrients you use, but how you get them, that has implications for cell fate control. Thread!
biorxiv.org
Amino acid intake strategies define pluripotent cell states
Mammalian pre-implantation development is associated with striking metabolic robustness, as embryos can develop in a wide variety of nutrient conditions including even the complete absence of soluble...