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In 1986 Staeheli et al seminal MX1 paper noted re: IFN/ISGs “it is not known...how many of these proteins are required for protection against a particular virus”. 37 yrs later, Phd student @mattbmcdoug's new paper shines a light. 1/3
John Schoggins
1,164 posts
John Schoggins
@jschoggins
Professor curious about how mammals 🧘♂️🦇 🐭 fight viruses🦠Devote inordinate amounts of time to yoga, breadmaking, coffee. Views my own.
- I am so excited my postdoctoral mentor Charlie Rice has received the Nobel Prize. A truly talented scientist and visionary in virology. What an honor and privilege to have spent 5 years in his lab.BREAKING NEWS: The 2020 #NobelPrize in Physiology or Medicine has been awarded jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice “for the discovery of Hepatitis C virus.”
- If you’re a scientist and feel strongly about this, make sure you ask yourself “what am I doing to effect change?” Check out @swingleft if you haven’t already. Promote science by flipping The House in 2018."The Republican effort to financially punish graduate students is striking...If a nation is to produce quality scholars then we need to make sure higher level education is affordable to everyone." #TrumpTaxScam salon.com/2017/12/10/the…
- 5 lingering COVID-19 questions: 1. Why do people respond so differently? 2. What’s the nature of immunity and how long does it last? 3. Has the virus developed any worrying mutations? 4. How well will a vaccine work? 5. What is the origin of the virus?
- It finally out! LY6E inhibits coronavirus, including SARS-CoV-2 (COVID-19) in vitro and mouse coronavirus in vivo. Our massive collab effort with @ProfVolkerThiel and RiceLab @RockefellerUniv. Co-first authors @katrinabmar @StephaniePfaen1 @utswnews
- SCIENCE wins!!
- Well that was awful. Had a case of #breakthrough #COVID19. Tested neg upon learning of exposure, but eventually symptomatic. Clinically “mild to moderate”, but experientially pretty miserable…posting more on that later. Just super grateful for vaccine! Happy to field questions.
- Replying to @TheMenacheryLabI hope people realize how generous posting this data is. Thank you.
- Looks like I’m a keeper!! #tenure
- Wow. Mitochondria make double stranded RNA that activate innate immune responses. nature.com/articles/s4158…
- Cloaked in mystery for decades, the RNA capping mechanism of coronavirus (SARS-CoV-2) is unveiled. Congrats to @UTSWNews colleague V.Tagliabracci & lead authors @ginajpark & A.Osinski for this amazing discovery. @HHMINEWS
- I’m all for SciComm, but the explosion of discussion on Twitter about virus evolution and viral variants has devolved into a complete shit show, largely because of non-experts with blue checkmarks & large followings tweeting/publishing hyperbolic speculations. Needs to stop!
- It should be abundantly clear by now that we need a better arsenal of antiviral therapies to treat active viral disease. Billions of dollars should go into basic research and development of new ways to treat human viral disease.
