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Daniel Bryan Goodman
@dbgoodman
Immuno/Synth Bio/ML. PI @PennMedicine/@parkerici. Using DNA synth, multiplex assays & generative models to understand & engineer immune cells. @geochurch alum.
Harvard/MIT ➡️ UCSF ➡️ UPenn
goodman-lab.org
Joined May 2009
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    Daniel Bryan Goodman
    @dbgoodman
    Apr 29, 2025
    Why test #celltherapies one-by-one when you can use multiplexed #SynBio, #proteinengineering & #ML to design, measure & track them at scale? The Goodman Lab @PennMedicine opens July 2025. We’re hiring Specialists & Postdocs! Apply @ bit.ly/42BnJNJ RTs appreciated!🙏
    20K
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    Daniel Bryan Goodman
    @dbgoodman
    Oct 22, 2024
    Big news! 🥳🥂 In July 2025, I will be joining the faculty of University of Pennsylvania, @Penn_CBIO. The Goodman Lab for Synthetic Immunology will combine synthetic biology, genome engineering, and ML-driven functional genomics to study and manipulate primary immune cells. 🧵1/3
    50K
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    Daniel Bryan Goodman
    @dbgoodman
    Jul 13, 2021
    Excited to share new work w/ co-lead @CamilliaAzimi, @MarsonLab @kickassscience1 @roybal_lab: using a method we call 'CAR Pooling', we tested many CARs in multiplex & found new non-T cell signaling domains which improve CAR-T efficacy. biorxiv.org/cgi/content/sh… 👇🧵 1/10
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    Daniel Bryan Goodman
    @dbgoodman
    Feb 9, 2018
    Perfect example of why @biorxivpreprint is so powerful: Important methodological problem identified simultaneously by 2 groups, (biorxiv.org/content/early/…, biorxiv.org/content/early/…). Less than two weeks later, a 3rd preprint with a potential solution: biorxiv.org/content/biorxi….
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    Daniel Bryan Goodman
    @dbgoodman
    Mar 7, 2020
    Just put up a new preprint w/ my @geochurch-lab colleague @Schubes0 & team. We show that ssDNA produced in vivo can be used for efficient barcoded genome editing. It scales to pools of millions of genomic edits! (1\6)
    biorxiv.org
    High throughput functional variant screens via in-vivo production of single-stranded DNA
    Tremendous genetic variation exists in nature, but our ability to create and characterize individual genetic variants remains far more limited in scale. Likewise, engineering proteins and phenotypes...
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    Daniel Bryan Goodman
    @dbgoodman
    May 22, 2022
    It is mind-blowing that this works at all. But to be clear, this is not reading the cell's transcriptome, just taking a high dimensional image of the cell itself and mapping that to transcriptome training data. 1/2
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    José Luis Ricón Fernández de la Puente
    @ArtirKel
    May 21, 2022
    No sequencing? No problem! You can shoot lasers at cells and read their transcriptomes at a single cell resolution (ht @AlexandreTrapp ) biorxiv.org/content/10.110…
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    Daniel Bryan Goodman
    @dbgoodman
    Aug 13, 2021
    Really cool new paper combining retrons + CRISPR spacer aquisition to record transcriptional events as sequential genomic barcodes. Some very impressive DNA jockeying. Retrons are the future. 😁 Congrats @seth_shipman @Schubes0 @jeffnivala @BhattaraiKline!
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    bioRxiv
    @biorxivpreprint
    Aug 12, 2021
    Reconstructing transcriptional histories by CRISPR acquisition of retron-based genetic barcodes biorxiv.org/cgi/content/sh… #bioRxiv
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    Daniel Bryan Goodman
    @dbgoodman
    May 6, 2022
    Why test #celltherapies one-by-one when you can use #SynBio to design, learn, and iterate on thousands in parallel? Our team @UCSF @MarsonLab @roybal_lab is #hiring a wetlab technician to help build the next revolution in genetically engineered medicine! DM for info & please RT!
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    Daniel Bryan Goodman
    @dbgoodman
    Dec 13, 2021
    I'm so pumped to apply our multiplexed #CellTherapy technology to #longevity research! Such an exciting time to begin expanding therapeutic immune cell engineering beyond cancer. 🙏🙏 to @MartinBJensen @LNuzhna and the #ImpetusGrants team for this opportunity.
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    Martin Borch Jensen
    @MartinBJensen
    Dec 13, 2021
    Replying to @MartinBJensen
    & 🎄 #ImpetusGrants to: 🪙 @corina_amor_MD, @CSHL 🪙 @dbgoodman, @UCSF for #CellTherapy development. 🪙 @DavisEnglund & @NKLeBRASSEUR, @MayoClinic 🪙 @RhysKAnderson, @KingsCollegeLon to identify genes critical for cellular #Senescence.
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    Daniel Bryan Goodman
    @dbgoodman
    Jun 30, 2023
    I had a blast talking about the future of T cell therapies tonight with the folks at @ManifoldBio - honored to be the inaugural speaker. Thanks for hosting me, @glebkuz! 🎉
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    Alex Reis
    @alexcampreis
    Jun 30, 2023
    Inaugural “Manifold Science Hour” by the one and only @dbgoodman @ManifoldBio
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    Daniel Bryan Goodman
    @dbgoodman
    Nov 2, 2021
    Not really evolution, but here's my fav: the synthetic genome assembly map I made in #Python + @ProcessingOrg for our 2013 GRO paper (science.org/doi/10.1126/sc…). This bad boy took more work than any fig I've made since, and in the end it ended up buried in the supplement! 😂
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    Daniel Bryan Goodman
    @dbgoodman
    Apr 29, 2022
    Never expected to have my dog's genome sequenced (esp. before mine!), but now it is in a study on the cover of @ScienceMagazine! Congrats @LindaBGoodman @eenork @morrilleen (& RIP Skyler 🐕♥️)
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    Linda Goodman
    @LindaBGoodman
    Apr 29, 2022
    New dog genomics study by @morrilleen @eenork et al. (@UMassChan & @broadinstitute) in @ScienceMagazine today. Proud to have contributed my lovable mutt’s DNA and bioinformatic analyses! Check out my @faunabio blog post on human health relevance: faunabio.com/blog/a-mutt-is…
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    Daniel Bryan Goodman
    @dbgoodman
    Oct 27, 2020
    Co-hosted an episode of the Translation podcast with @vram142 & @sethbannon! ML-guided design of AAV, synthetic proteins, and multiplexing all the things with @PierceJOgden. On the web: fiftyyears.com/translation-po… On Apple: podcasts.apple.com/us/podcast/tra… On Google: bit.ly/3jXmuQ6
    00:00
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    Daniel Bryan Goodman
    @dbgoodman
    Nov 1, 2019
    Hot take from @LindaBGoodman : Ghostbusters is really about disillusioned academics trying to translate their work into a startup. Plus ghosts are non-model organisms, right? @faunabio