De novo protein design has seen major success in scaffolding single functional motifs, however, in nature most proteins present multiple functional sites. Here we describe an approach to simultaneo...

Physical interactions between proteins are essential for most biological processes governing life. However, the molecular determinants of such interactions have been challenging to understand, even...

Predicting interactions between proteins and other biomolecules purely based on structure is an unsolved problem in biology. A high-level description of protein structure, the molecular surface,...