How do we keep pace with the growing number of aging biomarkers?
As the field expands, it faces a growing challenge: aging biomarkers are being developed faster than they can be systematically compared, evaluated, or reused.
We propose a unified framework for curating and
Establishing reliable biomarkers of aging for longevity interventions.
- ⌚ Digital biomarkers are nearly everywhere in longevity R&D. Wearables, remote monitoring, and AI-driven analytics are embedded in trials, prevention programs, and real-world studies. But adoption has outpaced understanding. Our 2025 Lancet Healthy Longevity paper is more
- Why aren’t biomarkers of aging widely used in the clinic yet? A 2026 reality check. Longevity R&D is accelerating rapidly: We now see more advanced aging clocks, multi-omics panels, digital biomarkers, and interventional trials than ever before. Biomarkers of aging are
- How do we know whether a biomarker of aging actually works? Here's a refresher for the field. Following our framework on defining biomarkers of aging, this Nature Medicine review tackled the next critical step: validation. The paper outlines what it takes for aging biomarkers
- Why does our inaugural 2023 paper matter more today than when it was released three years ago? Since then, the number of proposed biomarkers of aging has exploded. ⏳ Epigenetic clocks, proteomic signatures, metabolomic panels, digital and wearable-derived metrics,

