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Spencer Moore
430 posts
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Spencer Moore
@SponceyM
Scientist @herasight
Seattle, WA
herasight.com
Joined January 2022
1,479
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1,899
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  • Pinned
    user avatar
    Spencer Moore
    @SponceyM
    Oct 21, 2025
    Today we reveal CogPGT, the world’s most powerful genetic predictor of IQ. We achieve a correlation with IQ of 0.51 (0.45 within-family). Herasight customers can boost the expected IQ of their children by up to 9 points by selecting the embryo with the highest CogPGT score. 🧵
    2.7M
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 21, 2025
    Replying to @SponceyM
    Our study shows that powerful genetic prediction of cognitive ability is not only possible but likely to be highly beneficial when applied in embryo selection, resulting in meaningful increases in intelligence as well as reduced psychological problems and disease risks.
    33K
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 21, 2025
    Replying to @SponceyM
    Interested in using CogPGT in your IVF journey? Sign up here: herasight.com/contact-us/. Check out the CogPGT validation whitepaper here for all the scientific details: herasight-project.webflow.io/technical-pape….
    herasight.com
    Contact Us | Herasight
    Contact us with any questions, feedback, or inquiries. We’re here to assist you.
    54K
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 21, 2025
    Replying to @SponceyM
    In a held-out validation sample from the UK Biobank (UKB), CogPGT achieves a population correlation of 0.406 with measured fluid intelligence, implying a population correlation of 0.521 with latent general cognitive ability (g). Similar results were obtained in an independent
    47K
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 21, 2025
    Replying to @SponceyM
    We analyzed off-target effects of selection for IQ by correlating CogPGT with other outcomes, including behavioral phenotypes in 9-10 year olds. We find almost* uniformly beneficial correlations, including reduced ADHD symptoms and autistic traits with higher CogPGT score. *only
    43K
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 21, 2025
    Replying to @SponceyM
    We also looked at within-family associations between CogPGT, psychological traits and life outcomes in the UKB. CogPGT was associated with increased education, income, occupational status, friend satisfaction, health, and emotional stability.
    27K
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 21, 2025
    Replying to @SponceyM
    We found that the average CogPGT score among those in an occupation was strongly correlated with the (CAMSIS) occupational status of that occupation, with medical practitioners and higher education teaching professionals having the highest average CogPGT score.
    28K
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 21, 2025
    Replying to @SponceyM
    Higher CogPGT score was associated with lower risk for cardiometabolic diseases, including type 2 diabetes and coronary artery disease. Associations were consistent within-family, implying selecting for higher CogPGT score would slightly reduce cardiometabolic disease risk.
    26K
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 21, 2025
    Replying to @SponceyM
    Polygenic prediction accuracy is known to decrease with genetic distance from source data (here European). CogPGT followed this pattern, with correlations decreasing by up to 40% for African-American and East Asian samples, compared to only slight decreases for US Hispanics and
    22K
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 21, 2025
    Replying to @SponceyM
    Some previous results suggested that genetic effects on IQ vary by family background. We found no evidence for this when testing for interactions with family conflict, income, and parental education, suggesting similar effects by family background.
    26K
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 22, 2025
    A million views on a post introducing our important new research. It's gratifying seeing the reach this has gotten from just my personal account. Our @herasight inbox is blowing up with interest from couples looking to screen. Very exciting! Thanks to everyone who engaged.
    user avatar
    Spencer Moore
    @SponceyM
    Oct 21, 2025
    Today we reveal CogPGT, the world’s most powerful genetic predictor of IQ. We achieve a correlation with IQ of 0.51 (0.45 within-family). Herasight customers can boost the expected IQ of their children by up to 9 points by selecting the embryo with the highest CogPGT score. 🧵
    12K
  • user avatar
    Spencer Moore
    @SponceyM
    Dec 21, 2023
    Replying to @shakoistsLog
    Did he update his views?
    7.5K
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 22, 2025
    Replying to @mosasaurus27
    The reasons for decreased within-family performance are subtle and only recently characterized. For one, recent assortative mating (AM) (e.g. high IQ men with high IQ women) induces long-range and cross-chromosome correlations between trait-affecting variants. The effect of a
    science.org
    Deconstructing the sources of genotype-phenotype associations in humans
    Efforts to link variation in the human genome to phenotypes have progressed at a tremendous pace in recent decades. Most human traits have been shown to be affected by a large number of genetic...
    8.2K
  • user avatar
    Spencer Moore
    @SponceyM
    Oct 16, 2025
    I don’t think the EAS PRS performances shown in Figure 5 yet justify that statement, which seems to suggest that the best available EAS PRS models now meet or exceed the best available EUR ones. Since these PRSmix+ EAS PRSs were trained and tuned on only 363k + 80k Taiwanese TPMI
    This post is unavailable.
    23K