Simon Barnett (@SimonDBarnett) / X

Simon Barnett

1,007 posts

Simon Barnett

@SimonDBarnett

Partner + Head of Research @_DimensionCap | Focused on the Intersection of Compute + Bio | Prev: Public Biotech Investor | Chemical Engineering @JohnsHopkins

New York

research.dimensioncap.com

Joined June 2023

Pinned
Simon Barnett
@SimonDBarnett
Mar 31
Galileo's similarity theory powered centuries of industrialization, but living cells broke it. In my newest essay, I argue that encoding this theory as an inductive bias is the only way to transform #bioprocess scaling from alchemy back into engineering.
Simon Barnett
@SimonDBarnett
Mar 31
Article
Without Form and Void: Learning the Residual of Bioprocess Scale
Act I - The Venetian Arsenal Every swinging church bell and right-angled buttress beckoned to them with clues about the nature of reality. Early Morning The cool, morning air was thick with the...
5.8K
Simon Barnett
@SimonDBarnett
Jul 25, 2024
Last year, ~7% of the Protein Data Bank (PDB) structures came from this facility in England. Their X-ray crystallography throughput is near the top of the global leaderboard, and it's only accelerating. I was fortunate to take a tour of Diamond and now you can too.
50K
Simon Barnett
@SimonDBarnett
Jun 12, 2024
Not an ML expert, but want to understand AlphaFold3 (AF3)? I wrote a simple-to-understand AF3 field guide and sprinkled my opinions in along the way. The full essay is linked at the END of the thread. Here's a TL;DR 🧵
66K
Simon Barnett
@SimonDBarnett
Jul 11, 2024
Last week, @Novartis scientists published a beautiful paper on a potentially game-changing treatment for sickle cell disease (SCD). The article is paywalled, so I thought I'd summarize it in a brief thread! Check it out. 🧵⤵️
science.org
A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction
Sickle cell disease (SCD) is a prevalent, life-threatening condition attributable to a heritable mutation in β-hemoglobin. Therapeutic induction of fetal hemoglobin (HbF) can ameliorate disease...
38K
Simon Barnett
@SimonDBarnett
Mar 25, 2024
Replying to @WillManidis
It’s likely not the largest, but it is interesting. A mixup between metric and imperial units on shared planning docs infamously led to the scrubbing of a $234M (2024 dollars) NASA orbiter. simscale.com/blog/nasa-mars…
52K
Simon Barnett
@SimonDBarnett
Jan 29, 2025
I've stepped into a new role as a Partner and the Head of Research at @_DimensionCap. The past 18 months have been the most intense and fulfilling of my career. I'm incredibly proud of what this team has achieved in such a short period. Our best work is still ahead of us.
18K
Simon Barnett
@SimonDBarnett
Nov 23, 2023
My colleague .@EricDai_BioE and I recently visited MIT for the MoML conference (.@AIHealthMIT) on AI x drug discovery. Here's a breakdown of several key insights, debates, and perspectives 👇
63K
Simon Barnett
@SimonDBarnett
Sep 5, 2024
There are over 500 amino acids. Also known as non-standard, non-canonical, or even unnatural, these amino acids have diverse functions in Nature and appear to be imbuing therapies with superior physiochemical properties. Read more in my newest essay. tinyurl.com/3apurs2r
15K
Simon Barnett
@SimonDBarnett
Dec 9, 2024
It's nigh time to step into a new Dimension. This morning, we're announcing a $500M sophomore fund to similarly supercharge scientists, technicians, operators, and founders seeking to forge the razor's edge of computationally-driven biotech.
Dimension gets $500M to bankroll biotech’s convergence with tech
From biopharmadive.com
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Simon Barnett
@SimonDBarnett
Jul 31, 2024
I thought this was one of the most provocative images from the EVOLVEpro paper by @omarabudayyeh and @jgooten. Supported by experimental data, they assert that a protein's fitness and its activity are lowly, or even negatively, correlated. How could this be? Shouldn't nature
Omar Abudayyeh
@omarabudayyeh
Jul 19, 2024
Directed evolution is key for unlocking new protein function But is difficult and time consuming So how can we accelerate protein design by 10-100x? With AI! Now introducing EVOLVEpro, an LLM-based model for evolving proteins rapidly and efficiently biorxiv.org/content/10.110…
28K
Simon Barnett
@SimonDBarnett
Jun 24, 2024
In a new Perspective published today in @GENBiotechJrnl, John Chodera (@jchodera) and I give an optimistic view on the future of neural network potentials (NNPs) for enabling advanced small molecule discovery and design. liebertpub.com/doi/10.1089/ge… Summary Thread Below! 🧵
Neural Network Potentials for Enabling Advanced Small-Molecule Drug Discovery and Generative Design...
From journals.sagepub.com
51K
Simon Barnett
@SimonDBarnett
Aug 23, 2024
Article
The Four Eras of Antibody Manufacturing
Monoclonal antibody (mAb) production has undergone dramatic change since the first therapeutic mAb was approved in 1986. In an excellent manuscript, Brian Kelley from @Vir_Biotech chronicles how the...
29K
Simon Barnett
@SimonDBarnett
Dec 22, 2024
Last week, @RehaMathur, @bauer_lesavage, and I attended several ML + Biology workshops at #neurips2024. We've compiled our workshop notes as a community resource. Enjoy! tinyurl.com/3esnu2fw
14K
Simon Barnett
@SimonDBarnett
Jan 21, 2024
Last month, my colleague @EricDai_BioE and I attended dozens of Bio x ML workshops at @NeurIPSConf 2023. We've curated a list of papers, authors, and takeaways in a three part roundup series. Part 1 is on Generative Protein Design. research.dimensioncap.com/p/neurips-2023… TL;DR Below ⤵️
NeurIPS 2023 Roundup: Generative Protein Design
From research.dimensioncap.com
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