Luca Naef (@NaefLuca) / X

Luca Naef

557 posts

Luca Naef

@NaefLuca

Co-Founder & CTO, @proximabio Forbes 30u30 but won't go to jail | prev. ETH Zurich Stanford McKinsey AI x Bio/Chem. vi/vim

San Francisco, NYC, ZRH

proximabio.com

Joined September 2015

Pinned
Luca Naef
@NaefLuca
Mar 21, 2025
Extremely excited to give a glimpse of what we've been working on over the past 2 years: unifying structure-prediction and de-novo generation. Neo-1 is an all-atom, fully generative model
Proxima
@proximabio
Mar 21, 2025
Announcing Neo-1: the world’s most advanced atomistic foundation model, unifying structure prediction and all-atom de novo generation for the first time - to decode and design the structure of life 🧵(1/10)
00:00
35K
Luca Naef
@NaefLuca
Jul 19, 2024
💥 Introducing PINDER & PLINDER With existing evals saturating without clear advances in real life downstream tasks, current progress in AI x Bio is primarily rate-limited by better datasets & evals. In two back-to-back preprints, we address this via fantastic academic-industry
98K
Luca Naef
@NaefLuca
Jul 27, 2023
Like for so many, @mmbronstein's lectures & papers on Geometric Deep Learning really got me into the field. Incredibly thrilled to now join forces on our journey to unlock one of the most promising novel modalities!
Proxima
@proximabio
Jul 27, 2023
We are thrilled to announce that Geometric Deep Learning pioneer Michael Bronstein (@mmbronstein) has joined @VantAI as Chief Scientist in Residence! tinyurl.com/mr3r95t8 #ai #machinelearning #drugdiscovery
5.8K
Luca Naef
@NaefLuca
Jul 23, 2024
Meet us tomorrow at #ICML at 4pm in front of Hall A to chat AI x Bio evals & data, we have good chunk of the PINDER & PLINDER team here from @nvidia @vant_ai @mmbronstein
Luca Naef
@NaefLuca
Jul 19, 2024
💥 Introducing PINDER & PLINDER With existing evals saturating without clear advances in real life downstream tasks, current progress in AI x Bio is primarily rate-limited by better datasets & evals. In two back-to-back preprints, we address this via fantastic academic-industry
9.4K
Luca Naef
@NaefLuca
Sep 19, 2024
It doesn't require a lot of foresight to realize that this institute will end up in the history books and they could not have found a better person than @mmbronstein to lead it
Austrian Academy of Sciences
@oeaw
Sep 18, 2024
#AITHYRA is born! 🎉 OeAW is founding a new institute at the intersection of #AI & #biomedicine – the AITHYRA Institute. Meet the new founding director and DeepMind Professor of Artificial Intelligence @mmbronstein. Watch now ➡️youtu.be/pTA6DPQpxfo #boehringeringelheimstiftung
3.8K
Luca Naef
@NaefLuca
Jun 10, 2024
If you like numpy and protein structures, you'll love @biotite_python! We'll be upstreaming lots of internally useful tools as well
Proxima
@proximabio
Jun 10, 2024
We made it no secret that we love @biotite_python! So much so that Biotite's Patrick Kunzmann has recently joined the team. This is the first of many releases where Patrick is contributing some of the tools he's built at @vant_ai back to Biotite.
5.5K
Luca Naef
@NaefLuca
May 1, 2024
Match made in heaven! Probably among the largest H100 per researcher count in our field together with probably one of the largest proprietary structural datasets. If you are a researcher - work with us to solve the big remaining outstanding challenges in computational structural
Proxima
@proximabio
May 1, 2024
Thrilled to announce our collaboration with @googlecloud - providing a large fleet of NVIDIA H100 GPUs to train the world's foremost all-atom protein interaction foundation models using our proprietary large scale structural data businesswire.com/news/home/2024…
8.7K
Luca Naef
@NaefLuca
Sep 6, 2022
When @sacdallago pinged us for drug discovery use-cases for an LLM-based end-to-end pipeline for a review on protein design, of course our first question was: can we use this to design molecular glues? Turns out you probably can! 🧵 (1/5)
Christian Dallago
@sacdallago
Sep 6, 2022
Our pre-print cataloguing generative deep learning tools for protein design is available on @biorxivpreprint : biorxiv.org/content/10.110… . We aimed it at practitioners wondering how to navigate design tools. Short 🧵 for one of the stories in the manu...
Luca Naef
@NaefLuca
Mar 18, 2024
What makes problems ripe for disruption through DL? Why are there limited breakthroughs in Bio x AI so far? In this post we argue that not every problem is equally suited but there are clear common patterns - and to unlock new problems we need to move beyond “white-box” data
Michael Bronstein
@mmbronstein
Mar 18, 2024
In a new post with @NaefLuca @vant_ai we ask what is needed for ML to succeed in biological problems and argue that it is necessary to move beyond "white-box data" michael-bronstein.medium.com/the-road-to-bi… w inputs from @nathanbenaich @dom_beaini @befcorr @georg_e_winter @schwabpa @ggrigoryanv
8.9K
Luca Naef
@NaefLuca
Mar 13, 2024
There's also rumors about company ski trips that I cannot confirm nor deny
Proxima
@proximabio
Mar 13, 2024
📢 The VantAI team is growing in Europe! A picture of today's team lunch in Zurich with @mmbronstein in town. We're hiring for Machine Learning, Engineering, Comp Bio/Chem and all other scientific positions. E-Mail at [email protected]
6.3K
Luca Naef
@NaefLuca
Feb 13, 2024
What an incredible honor to work with some of the pioneers in our field on this paradigm shifting modality. Was great to sit down with @Forbes and chat about what makes this so exciting!
Proxima
@proximabio
Feb 13, 2024
We are thrilled to announce a new milestone collaboration with Bristol Myers Squibb (@bmsnews), utilizing our geometric deep learning platform for the rational design of novel molecular glues. Founder & CEO Zachary Carpenter, and Co-Founder & CTO Luca Naef, sat down with
2.5K
Luca Naef
@NaefLuca
Dec 17, 2021
We're hiring for computational chemists. Cutting edge R&D to develop the future methods of designing proximity inducers, at the intersection of ML & biophysics! RT welcome linkedin.com/jobs/view/comp… #compchem #chemjobs #machinelearning #drugdiscovery #hiring
linkedin.com
Computational Scientist jobs in United States
Today's top Computational Scientist jobs in United States. Leverage your professional network, and get hired. New Computational Scientist jobs added daily.
Luca Naef
@NaefLuca
Jul 19, 2024
Replying to @NaefLuca
🥇 We find that current performance estimates are not only inflated by up to 2-3x, but surprisingly & excitingly, also that deliberate splits + clustering allows training models that generalize much better! Via extensive benchmarking and retraining of DiffDock(-PP), enabled by
13K
Luca Naef
@NaefLuca
Jul 19, 2024
Replying to @NaefLuca
⬆️ PINDER & PLINDER are the Protein-protein/Ligand INteraction Dataset and Evaluation Resource - >500x and 10x larger datasets than previous datasets and provide predefined splits that leverage novel interface-clustering and splitting procedure together with strict quality
5.1K