Martin Pacesa (@MartinPacesa) / X

Martin Pacesa

2,442 posts

Martin Pacesa

@MartinPacesa

Assistant Professor at the University of Zurich. 🖥️ protein design, machine learning🤖, crystallography💎, cryoEM🔬. Avid weirdness connoisseur 🎩

Zurich, Switzerland

Joined December 2018

Martin Pacesa
@MartinPacesa
Oct 2, 2024
Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. @befcorreia @sokrypton biorxiv.org/content/10.110…
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Martin Pacesa
@MartinPacesa
Jun 19, 2024
Today in @Nature we present the results of our exploration of the soluble protein universe and the design of functional soluble membrane proteins with @CasperGoverde @GoldbachNico @befcorreia 1/6 nature.com/articles/s4158…
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Martin Pacesa
@MartinPacesa
May 17, 2023
OMG, WE'VE BEEN WAITING FOR YEARS AND IT'S HERE! THE NEW CRISPR CLASSIFICATION IS HEREEEE!!! 🔥🔥🔥 pubs.acs.org/doi/10.1021/ac…
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Martin Pacesa
@MartinPacesa
Aug 27, 2025
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, @csche11h, @sokrypton, @befcorreia and many other amazing lab members and collaborators. nature.com/articles/s4158…
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Martin Pacesa
@MartinPacesa
Jul 25, 2025
I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
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Martin Pacesa
@MartinPacesa
Oct 27, 2022
I’m so happy to announce that the results of our study on the mechanistic basis of Cas9 off-target activity have been published in Cell! cell.com/cell/fulltext/…
Martin Pacesa
@MartinPacesa
Dec 10, 2022
AlphaFold/ColabFold no longer dominating at this year’s CASP15 😮
Martin Pacesa
@MartinPacesa
Aug 24, 2022
Very excited to see our work on Cas9 conformational activation out in @Nature ! nature.com/articles/s4158… What started as a very poor crystal structure back in 2017 in the @MartinJinek lab, turned into a full blown cryoEM project during the pandemic.
Martin Pacesa
@MartinPacesa
Apr 13, 2019
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Martin Pacesa
@MartinPacesa
Mar 8, 2024
THEY SAID WE COULDN'T DO IT........well, no one actually said that. But in our updated manuscript with @CasperGoverde, @GoldbachNico, and @befcorreia we show you can now design soluble analogues of membrane proteins with preserved functional features! biorxiv.org/content/10.110…
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Martin Pacesa
@MartinPacesa
Dec 30, 2024
Just before the New Year: BindCraft v1.5! Please fill out this form to request new features and help us make BindCraft even better. forms.gle/XsGHDCyHtczVba…
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Martin Pacesa
@MartinPacesa
Feb 27, 2024
This peptide structure is wild (PDB 1ALZ)
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Martin Pacesa
@MartinPacesa
Nov 6, 2024
v1.2.0 of BindCraft released on github. Includes improvements to the Colab notebook, new design protocol options, several critical bug fixes in the run script, QoL improvements, and streamlining of the installation script.
Martin Pacesa
@MartinPacesa
Oct 2, 2024
Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. @befcorreia @sokrypton biorxiv.org/content/10.110…
00:00
29K
Martin Pacesa
@MartinPacesa
Nov 19, 2021
I am happy to conclude my trilogy on Cas9 specificity with our new preprint from the @MartinJinek lab! We solved a staggering number (15!) of crystal structures of Cas9 bound to bona fide off-targets to investigate the nature of mismatch tolerance. biorxiv.org/content/10.110…