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Jay Shendure
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Jay Shendure

@JShendure
Genomics technology developer. Developmental biology adult learner. Professor at @uwgenome @HHMINEWS @BrotmanBaty SeaHub @AllenInstitute /him.
Seattle, WA
krishna.gs.washington.edu
Joined May 2011
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    Jay Shendure
    @JShendure
    Jul 31
    Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n
    GIF
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    Jay Shendure
    @JShendure
    Jul 30
    New preprint from Shendure Lab on Locus-Scale aka Long-@$$ MPRAs led by the amazing Abby McGee & @CGBiar! Most MPRAs test ~300 bp fragments next to a promoter. But real enhancers are bigger, act combinatorially and from a distance. 1/n biorxiv.org/content/10.648…
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    Jay Shendure
    @JShendure
    Jun 4
    Our latest w/ @sudpinglay Lab -- Shred-seq for gigabase-scale deletion scanning of the human genome! Amazing work by @JonasKoeppel
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    Jonas Koeppel
    @JonasKoeppel
    Jun 3
    1/n What fraction of the human genome is essential for cellular viability? Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads. @sudpinglay @JShendure biorxiv.org/content/10.648…
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    Jay Shendure
    @JShendure
    Apr 29
    Really thrilled by the framing and scale of this new @biohub initiative, including the combination of internal & external investment in tech-dev, open data, modeling and collaborative science, all good things!
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    Alex Rives
    @alexrives
    Apr 29
    Scaling laws are powering AI. It’s time to scale biology. Today we’re launching the Virtual Biology Initiative to generate the data to unlock scaling laws in biology and build accurate predictive models of the cell. Digital representations of proteins are already expanding our
  • user avatar
    Jay Shendure
    @JShendure
    Oct 14, 2025
    Super excited re: first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to brilliant Chase Suiter & @Green_Ahn @UWproteindesign on the work! Preprint: biorxiv.org/content/10.110…

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