Donal O'Carroll

28 posts

Donal O'Carroll

@CarrollDonal

RNA, epigenetics & the germline😀

Scotland, United Kingdom

Joined May 2019

Donal O'Carroll
@CarrollDonal
Jul 6
An amazing collaboration with @JPLab_. See our apo-PIWI-HSP90α/β structures:
biorxiv.org
The structure of the apo-PIWI HSP90 complex
PIWI proteins are members of the Argonaute family and together with piRNAs protect metazoan germlines from transposons. PIWI proteins adopt a bi-lobed architecture with a central RNA-binding channel....
Donal O'Carroll
@CarrollDonal
Sep 18, 2024
Interested in piRNAs and transposon DNA methylation? Our new collaborative work revels a key mechanism underpinning the precision of piRNA-guided LINE1 methylation. Congratulation to all the authors!
Two-factor authentication underpins the precision of the piRNA pathway
From nature.com
Donal O'Carroll
@CarrollDonal
Aug 9, 2024
nature.com/articles/s4146… Delighted we could participate in this amazing study. It shows that the piRNA pathway is central to supporting human male fertility and transposon silencing .
nature.com
Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and...
Nature Communications - piRNAs are small RNA molecules found primarily in the testes of mice and men. Stallmeyer et al. demonstrate that variants in specific genes can disrupt the formation of...
Donal O'Carroll
@CarrollDonal
Jan 5, 2024
Interested in understanding the dynamics of hematopoietic homeostasis, take a look at our freshly published collaborative study: authors.elsevier.com/sd/article/S19… Well done to all the authors. It was fantastic to collaborate with the @BertieGottgens and @kamilkranc labs.
Donal O'Carroll
@CarrollDonal
Feb 16, 2021
The O’Carroll lab is looking for talented postdoctoral research associates to join us in our quest to explore piRNA-directed DNA methylation.
elxw.fa.em3.oraclecloud.com
Postdoctoral Research Associate
The School of Biological Sciences, Institute for Stem Cell Research, is seeking to appoint two Postdoctoral Research Associates on full time, fixed-term contracts, to explore the mechanisms by which...