Pharmaceutical Chemistry

El motivo principal de este tomo regional, surgio de la necesidad de comprender el contexto que influyo durante decadas en el desarrollo del conflicto armado en Colombia durante mas de medio siglo, teniendo en cuenta que la diversidad geografica del pais, requiere necesariamente un analisis regional de este fenomeno. A pesar de la extensa produccion historiografica que existe sobre el conflicto armado, el proposito de esta investigacion se fundamento en establecer las coordenadas del origen y las caracteristicas del conflicto armado colombiano, mediante la recuperacion de documentos militares, construyendo una vision desde la perspectiva de las Fuerzas Militares. Por lo que el presente texto ofrece una lectura que busca orientar el contexto politico, social y economico que permeo la actuacion de las Fuerzas Militares en la jurisdiccion actual de la Cuarta Division del Ejercito Nacional (Departamentos del Meta, Guaviare y Vaupes).

Molecular tests for viral diagnostics are essential to confront the COVID-19 pandemic, but their production and distribution cannot satisfy the current high demand. Early identification of infected people and their contacts is the key to being able to isolate them and prevent the dissemination of the pathogen; unfortunately, most countries are unable to do this due to the lack of diagnostic tools. Dogs can identify, with a high rate of precision, unique odors of volatile organic compounds generated during an infection; as a result, dogs can diagnose infectious agents by smelling specimens and, sometimes, the body of an infected individual. We trained six dogs of three different breeds to detect SARS-CoV-2 in respiratory secretions of infected patients and evaluated their performance experimentally, comparing it against the gold standard (rRT-PCR). Here we show that viral detection takes one second per specimen. After scent-interrogating 9,200 samples, our six dogs achieved independe...

Multiwall carbon nanotubes were grown inside the millimetric channels of commercial ceramic materials, cordierite monoliths, using a modified catalytic chemical vapor deposition method. Fe(CO)5 liquid catalyst precursor was introduced in gas phase at the same time as the acetylene carbon source to allow a more uniform distribution of carbon nanotubes on the substrate surface. Different techniques were used for the characterization of the obtained multiwall carbon nanotubes such as scanning and transmission electron microscopies, N2 adsorption isotherms, Raman spectroscopy and thermogravimetric analysis. The results show that the surface of the ceramic monolith is progressively covered with multiwall carbon nanotubes reaching total coverage for longer times under reaction. The carbon nanotubes were built up with a tree-like morphology. So, firstly larger carbon nanotubes are formed as the tree trunks on the cordierite surface, followed by the growing on them of narrower and longer na...

Prenylhydroxybenzoic acid derivatives and other two analogues previously reported were isolated from Piper arieianum leaves. The structures of the compounds were assigned from detailed spectroscopical analysis (NMR 1D and 2D and HR ESI TOF MS) data and by comparison with data from the literature. These molecules posses pungent activity different to that of capsaicin and their activity is related to their structure and their mechanism of action can involve interactions with TRPV1 channel.

PRENILHIDROXIBENZOICOS DE Piper arieianum RESUMEN En el presente artículo se describe el aislamiento e identificación de compuestos del tipo prenilhidroxibenzoicos obtenidos del extracto de hojas de Piper arieianum que ha presentado actividad leis hmanicida. El aislamiento se llevo a cabo empleando los métodos tradicionales de cromatografía y la identificación estructural mediante técnicas de RMN 1 H y 13 C

La leishmaniasis es una enfermedad ampliamente difundida en América latina, desafortunadamente para su tratamiento hay muy pocas drogas, que tambien tienen una baja efectividad. Por esta razón el mundo urge de nuevas y más efectivas moléculas. En la búsqueda de ...

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Prenylhydroxybenzoic acid derivatives and other two analogues previously reported were isolated from Piper arieianum leaves. The structures of the compounds were assigned from detailed spectroscopical analysis (NMR 1D and 2D and HR ESI TOF MS) data and by comparison with data from the literature. These molecules posses pungent activity different to that of capsaicin and their activity is related to their structure and their mechanism of action can involve interactions with TRPV1 channel.