PRESENTATION ON STUDENTS INDUSTRIAL WORK
EXPERIENCE SCHEME
UNDERTAKEN AT
SAM ACE PHARMACEUTICAL MANUCTURING IINDUSTRY
AKODA EDE OSUN STATE
BY
OYEYINKA LOVE OLUWATOSIN
(125/21/1/0093)
DEPARTMENT OF CHEMICAL AND PETROLEUM ENGINEERING
26TH OF NOVEMBER 2025
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PRENSENTATION OUTLINE
BRIEF HISTORY OF SIWES
BRIEF HISTORY OF SAM ACE PHARMACEUTICAL LIMITED
WET CHEMISTRY LAB
STABILITY TEST
CONCLUSION
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BRIEF HISTORY OF SIWES
• WHAT IS SIWES ?
The student industrial work experience scheme {SIWES} is the accepted training program which
form part of the approved minimum academic standard in all Nigerian tertiary institution, the
scheme require student to undergo the training in an organization or industries for 24weeks in
their third or fourth academic year in universities.
Student industrial work experience scheme {SIWES} was establish by industrial training funds
{ITF} to solve the problem of lack practical skills preparatory for employment in industries by
Nigerian graduate of tertiary institution.
The student Industrial work Experience Scheme {SIWES} is a program that was introduced by
the federal government and coordinated by Industrial Training Funds{ITF} in 1973 in conjunction
with National university commission} {NUC} aim at exposing student of tertiary institution
{University ,polytechnic, college of education and college of Agriculture} to the world of
organization and industries in order to bridge between theoretical aspect learnt in school and the
practical aspect learn in organization and industries.
•
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manufacturing , importing ,exporting ,supplying and distributing medical, veterinary and hospital
equipment , materials
BRIEF HISTORY andPHARMACEUTICAL
OF SAM CAE products. In 2003 the company LIMITED
MANUFACTURING ventures into a small scale production of
ORS (oral rehydration salt)
In 2005 the management decided to expand powder production to include manufacturing oral
antibiotics in dry powder form for various suspensions . In 2010 the company moved its production
activities to a newly built factory at plot 9-10, Akoda industrial estate , kilometer 14, gbongan -
Ibadan Akoda ede osun state Nigeria and the company expanded its production to included capsules
and suspension. They produce:
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ORGANAZATION STRUCTURE
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QUALITY CONTROL(CHEMISTRY LAB)
• Quality control is a crucial part of pharmaceutical company that ensure the authentication of the product being produced . The quality
control consist of :
A. Quality assurance
B. In process
C. Wet chemistry lab
D. Microbiology lab.
•
• Wet chemistry lab: This is where analysis on raw materials ,bulk and finished product are being done .The chemistry lab is responsible for
conducting various test to ensure the quality ,purity and safety of raw materials , intermediate and finished product.
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STABILITY TESTING IN DRUGS
• Potency loss: Drug loses their potency easily even before their expiration date
despite appearing intact.
• Degradation : when drugs loses their potency up to 60%, they are considered
impotent.
• Stability test: This test evaluates the level of potency in a drug to ensure it
remains effective and safe for consumption.
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STABILITY TESTING IN DRUGS
Stability Test: This is the evaluation of a substance ability to resist degradation , decomposition or reaction under specific condition
stability testing , product are exposed to controlled environments such as temperature (room temperature, elevated temperature),
humidity and pressure .
1a. Room Temperature stability (25 degree Celsius ): The product is subjected to normal temperature and the product is being
verified to determine the potency and product stability over a longer period of time (6-12 month).This is to stimulate real world stor
condition to ensure product quality and safety as it represent typical storage condition.
• 1b. Elevated Temperature Stability (40 degree Celsius): The product are being subjected to higher temperature and accelerated
degradation reactions , allowing changes to be observed in a shorter period of time . Accelerated temperature stability is done to
estimate product shelf life .
• 2. Humidity (25-30%): Humidity is an important factor to consider, as change in humidity can affect the potency and stability of
drug.
3. Pressure(1atm):Pressure is an important factor in stability testing because it can affect drug degradation,moisture ,
absorption,packaging interity and vapor pressureinfo@[Link]
[Link] which can drug stability potency. @techu_ibadan
STABILITY TESTING: IODOMETRY TITRATION
• A crucial volumetric analysis is done on stability drug where iodomerty is used to calculate the
potency of the drug.
• As a volumetric analysis ,iodometry titration involves measuring the volume of iodine solution
required to react with a known volume of the substances being analyzed . The reaction involves the
reduction of iodine to iodide and the endpoint is typically detected using a starch indicator. This
allows for the quantitative determination of the substances concentration.
• The following process are being followed:
0.29 of the sample given is dissolved into 200ml of water and 2ml of the sample is taken out and
transfer into a conical flask and 2ml of NaoH is added and stopper is added immediately and let sit for
15min after 2ml of HCL and 10ml of I2(iodine) and cover for another 15min and finally titrate with
Na2S2O3 (Sodium thiosulfate) and 3drops of starch is added.
For the blank :2ml of the sample given is taken into a conical flask and 10ml of iodine is added
and thiosulpuphate is titrated into it . The calculation goes thus:
Result= Blank – Sample
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2. PH Test: This is a fundamental analytical technique that determine the acidity or basicity of a
solution ,this is a critical parameter in drug as it affect drug stability , solubility and bioavailability. 30g
STABILITY
into 60ml TEST
of water.
3. Disintegration Test: This is the evaluation of the ability of a pharmaceutical
product(tablets ,capsules) to break apart and release its active ingredient in a controlled manner. The
water is subjected to human body temperature(37 degree) and the two capsule is dropped into it and
the time that it takes to dissolve is checked .Specification: 5min. This process is to check whether the
gelatin is hard or not.
4. Loss on Drying (LOD): LOD is checked on a bulk drug to determine its moisture and volatile content,
which can affect stability, potency, and shelf-life. Excess moisture may cause degradation, microbial
growth, or poor flow during manufacturing. Measuring LOD ensures the bulk material meets quality
specifications before further processing.
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EQUIPMENT USED IN STABILITY
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CONCLUSION
In conclusion ,stability testing is a crucial process in pharmaceutical development that
ensures the quality , potency and safety of product to various to various temperature so
that most of the product can be predicted due to storage condition, transportation
condition and usage. This experience has opened up to real life experience in working with
analysis and various equipment in the lab and has taught me how to consider various
factors in a laboratory setting.
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THANK YOU
FOR
LISTENING
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