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NIPT 16x9 Poster

Non-invasive prenatal testing (NIPT) offers a safe and accurate method for detecting chromosomal abnormalities using cell-free fetal DNA, with high sensitivity and specificity. It is recommended for high-risk pregnancies, such as those involving advanced maternal age or previous chromosomal anomalies. NIPT can be performed as early as 10 weeks and reduces the need for invasive procedures like amniocentesis.

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Jeevan Jyoti Sharma
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49 views1 page

NIPT 16x9 Poster

Non-invasive prenatal testing (NIPT) offers a safe and accurate method for detecting chromosomal abnormalities using cell-free fetal DNA, with high sensitivity and specificity. It is recommended for high-risk pregnancies, such as those involving advanced maternal age or previous chromosomal anomalies. NIPT can be performed as early as 10 weeks and reduces the need for invasive procedures like amniocentesis.

Uploaded by

Jeevan Jyoti Sharma
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

NON-INVASIVE PRENATAL TESTING

INTRODUCTION CASE SNAPSHOT REAL CASE SNAPSHOT


Presentation by Dr. Jeevan Jyoti Sharma
[Guide: Dr. Manjusha
Prenatal detection of chromosomal
Bajaj]
abnormalities has moved from serum and
Trisomy 21 (Down): >90%
Trisomy 18 (Edwards): ~97%
27 y/o G2A1
NT scan normal
invasive diagnostic procedures (CVS, Trisomy 13 (Patau): High High risk for Klinefelter (47,XXY)
amniocentesis) to accurate, safe, early Sex chromosome: X|Y Confirmed by amniocentesis
CONDITIONS DETECTED
non-invasive testing using cell-free fetal Microdeletion (e.g. 22q11) Counseling on prognosis & decision-
DNA. CLINICAL INSIGHT making
REFERENCES
✔ Non-invasive
✔ High sensitivity & specificity
✔ Early testing (from 10 weeks) NIPT shows superior detection of - ACOG Practice Bulletin 226
✔ Reduces need for invasive procedures sex chromosome aneuploidies even - Blanchi DW et al. N Engl J Med
✔ Useful in high-risk pregnancies when conventional markers are
normal.
INDICATIONS FOR NIPT

- Advanced maternal age (>35 years)


- Abnormal 1st/2nd trimester screening
- Previous chromosomal anomaly
- Ultrasound markers of aneuploidy
- Parental translocation/genetic risk

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