DEFINITION
High-alert medications are medications that bear a heightened
risk of causing significant patient harm when they are used in
error.
- ISMP
Adhering to safe practices protocol can reduce the potential for
harm
Poorly written medication orders.
Incorrect dilution procedures.
Confusion between IM, IV, intrathecal, preparations.
Confusion between strengths of the same medications.
Wrong infusion rate.
Look alike or sound alike product and similar packaging.
Classes/Categories of High Alert
Medications Examples:
Antithrombotic agents (anticoagulants), including warfarin, low molecular weight heparin, IV
unfractionated heparin
Chemotherapeutic agents, parenteral and oral
Epidural or intrathecal medications
Hypoglycemics, oral
Narcotics/opiates, IV, transdermal, and oral (including liquid concentrates, immediate and
sustained-release formulations)
Radiocontrast agents, IV Classes/Categories of Medications
Special Medication Examples
Insulin, subcutaneous and IV
Magnesium sulphate injection
Potassium chloride for injection concentrate
Sodium chloride for injection, hypertonic (greater than 0.9%
concentration)
TOP 5 HIGH – ALERT
MEDICATIONS
1. Insulin
2. Opiates & Narcotics
3. Injectable potassium chloride or potassium concentrate
4. Intravenous anti-coagulants (heparin)
5. Sodium chloride solutions above 0.9 %
Explain the goal with relevance to daily work in
hospital
Strategies may include:
Standardizing the ordering, storage, preparation, and
administration of these medications
Improving access to information about these drugs
Limiting access to high-alert medications
Using auxiliary labels and automated alerts
Employing redundancies