INJECTABLE PLATELET
RICH FIBRIN
Platelet-rich plasma (PRP) First experiments concerning blood Kingsley 1954 1
Coagulation
Fibrin glue Observed better outcomes in the Matras 1970 15
heal-
ing of wounds seen in rat models
Platelet-fibrinogen-thrombin Observed better outcomes in the Rosenthal AR 1978 16
mixtures heal-
ing of wounds seen in rat models
Platelet-derived wound healing suggested that platelet Knighton 1986 17
factors concentrate ef-
fectively enhance healing
PRF developed in France and named Choukroun 2000 20
due to
the strong fibrin gel while
polymeriza-
tion
Platelet Rich Gel considered as an activated fibrin Bielecki T 200621; Bielecka A
matrix 2007 22 Bielecka A 200923
rich in leukocytes, platelets &
active
molecule
Injectable- PRF The detailed technical note on Mourão 2015 32
prepara-
tion of i-PRF which forms the
orange
PROPERTIES OF i-PRF
1. i-PRF has been observed higher release of growth factor at the end of ten
days
2. i-PRF demonstrated higher cellular migration.
3.The higher antimicrobial activity with I-PRF in case of Porphyromonas
gingivitis.
4.i-PRF has the bonding characteristics with the bone graft
5.i-PRF is fibronectin which is an extracellular glyco-
protein with a high molecular weight (440 kDa).
DISCUSSION
Liquid PRF was prepared according to low speed of
centrifugation.
2. The liquid PRF is generated using a blood collection tube with
a plastic surface that enables the generation of liquid RPF
matrix without the use of external anticoagulants.
3. The liquid PRF preserve its liquid conditions for
approximately 15 to 30 min at room temperature and forms a
fibrin clot thereafter
4. A small syringe with an 18G hypodermic needle is used for
collection of I-PRF.
ADVANTAGES
1. It is in injectable form.
2. Can be used alone or in a combined
form with various biomaterials.
3. The capacity of a high amount of
regenerative cells with the release of more
growth factors.
4. Formed a small fibrin clot with that
worked as a dynamic gel.
6. It decreases the probability of adverse
reaction.
CONCLUSION
1. It influences osteoblastic behaviour
with a tremendous release of growth factors alone or in combination
with biomaterials.
2. Due to the presence of growth factors and platelets it has the
efficiency to convert osteo-conductive into osteopromotive.
3.Thus i-PRF has been demonstrated as modernized tools and
achieved predictable outcomes in the dentistry field.
