Scribd
Upload
31 views6 pages

ECM Protein Interaction Mapping

Uploaded by

Eshetu Mekonnen
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd
31 views6 pages

ECM Protein Interaction Mapping

Uploaded by

Eshetu Mekonnen
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd

Structure Function and Evolution of the

Graham Cromar and Dr. John Parkinson

Program in Molecular Structure and Function


Hospital for Sick Children
Toronto, ON, CANADA

Committee Members: Dr. Johanna Rommens


Dr. Andrew Emili
Dr. Gary Bader

In the lab: Dr. Jose Peregrin-Alvarez, Dr. James Wasmuth,


Chris Sanford, David He
Extracellular Matrix
Aims

Map known disease genes onto the functional map to


understand how the ECM is involved in health and disease.
Protein Databases Methods
Uniprot RefSeq Ensembl

Filter
Cellular Component = ECM
Biological Process
Molecular Function

Gene Ontology
Render

Interaction Databases

DIP
BioGRID
Database of Search
ECM proteins IntAct
Mint
The network was
constructed, then expanded
using orthologues
Mouse 613
Human
190 4 354
Human 28
807
Mouse

1267 1611
166
Rat
69 463
69
Rat

Mouse – 2268
Rat – 1910 Human - 2252
Human - 1165
Interesting biological
results?
8,3,1,2,4
18,12

14,8,17,25
5,7,6,9

5,6,11,12,23

You might also like