INSTRUMENTATION IN
PHARMACEUTICAL
INDUSTRY
PRESENTED BY,
JABIR HUSSAIN V.I
S5 I.E
ROLL NO:24
REG NO:2101080180
CONTENT
• INTRODUCTION
• BRANCHES OF INSTRUMENTATION IN
PHARMACEUTICAL INDUSTRY
• COMMONLY USED INSTRUMENTATION IN
PHARMACEUTICAL INDUSTRY
• ADVANTAGES
• DISADVANTAGES
• CONCLUSION
INSTRUMENTATION IN PHARMACEUTICAL
INDUSTRY
• Instrumentation in the pharmaceutical industry refers to the
use of various instruments and equipment to support and
enhance the manufacturing, analysis, and quality control
processes involved in the production of pharmaceutical
products.
• Instrumentation provides necessary tools and systems for
monitoring, controlling and analyzing the various processes
involved in the production of pharmaceutical products
INSTRUMENTATION IN PHARMACEUTICAL
INDUSTRY IS USED FOR
• Drug Development
• Manufacturing Processes
• Quality Control
• Safety and Efficacy
• Research and Innovation
BRANCHES OF INSTRUMENTATION IN PHARMACEUTICAL
INDUSTRY
• Analytical Chemistry
• Quality Control and Quality Assurance
• Process Control and Monitoring
• Biotechnology and Genetic Engineering
• Pharmacokinetics and Drug Delivery
ANALYTICAL CHEMISTRY
• Involves the identification and quantification of chemical
substances. Instruments such as gas chromatographs (GC),
high-performance liquid chromatographs (HPLC), mass
spectrometers (MS), and spectrophotometers are commonly
used to analyze pharmaceutical compounds, ensure their
purity, and monitor the quality of drug formulations
QUALITY CONTROL AND QUALITY
ASSURANCE
• Instrumentation is vital for quality control and quality
assurance in the pharmaceutical industry. Instruments like
dissolution testers, disintegration testers, hardness testers, and
friability testers are used to assess the physical properties and
performance of dosage forms such as tablets and capsules.
• In addition, instruments such as UV-visible
spectrophotometers, infrared spectrometers, and atomic
absorption spectrometers are employed to verify the chemical
composition and purity of pharmaceutical products
PROCESS CONTROL AND MONITORING
• Instrumentation is used extensively in pharmaceutical
manufacturing to control and monitor various processes.
• Instruments such as pH meters, conductivity meters,
refractometers, and viscometers are utilized to measure and
control parameters such as pH, conductivity, refractive index,
and viscosity during drug formulation and production
BIOTECHNOLOGY AND GENETIC ENGINEERING
• Biotechnology and Genetic Engineering Instrumentation is
used extensively in pharmaceutical manufacturing to control
and monitor various processes.
• It is used for vaccine development, protein expression and
production , drug discovery etc.
• mainly used instruments are PCR,DNA sequencer,
electrophoresis equipment, spectrophotometer
PHARMACOKINETICS AND DRUG DELIVERY
• Instrumentation is employed in pharmacokinetics studies to
determine the absorption, distribution, metabolism, and
excretion of drugs in the body.
• Techniques such as liquid chromatography-mass spectrometry
(LC-MS), nuclear magnetic resonance (NMR) spectroscopy,
and bioanalyzers are used to measure drug concentrations in
biological samples.
• Additionally, instruments such as drug delivery pumps,
inhalers, and transdermal patches are utilized to administer
pharmaceutical compounds to patients.
COMMONLY USED INSTRUMENTATION IN
PHARMACEUTICAL INDUSTRIES
• High-performance liquid chromatography (HPLC)
• Mass spectrometry (MS)
• Infrared (IR) spectroscopy
• Ultraviolet-Visible (UV-Vis) spectroscopy
• Nuclear magnetic resonance (NMR) spectroscopy
• Differential scanning calorimetry (DSC)
• Particle size analysis
• High-performance liquid chromatography (HPLC):
o This is a powerful technique used to separate and analyze
complex mixtures of compounds in a sample. It is often
used for drug discovery and development, as well as
quality control in drug manufacturing.
• Mass spectrometry (MS):
o This technique is used to identify and quantify the
chemical composition of substances. In the pharmaceutical
industry, MS is used for drug discovery and development,
quality control, and forensic analysis
• Infrared (IR) spectroscopy:
o This technique is used to analyze the chemical structure
of substances. It is often used in the pharmaceutical
industry for quality control and to ensure drug purity.
• Ultraviolet-Visible (UV-Vis) spectroscopy:
o This technique is used to measure the absorbance of light
by a substance. It is often used in the pharmaceutical
industry for quality control and to ensure drug purity
• Nuclear magnetic resonance (NMR) spectroscopy:
o This technique is used to determine the structure of
molecules. It is often used in the pharmaceutical industry
for drug discovery and development.
• Differential scanning calorimetry (DSC):
o This technique is used to study the thermal behavior of
substances. It is often used in the pharmaceutical industry
for drug development and quality control.
• Particle size analysis:
o This technique is used to measure the size and
distribution of particles in a sample. It is often used in the
pharmaceutical industry for drug development and quality
control.
ADVANTAGES OF INSTRUMENTATION IN
PHARMACEUTICAL INDUSTRY
• Accuracy and Precision
• Process Optimization
• Quality Control
• Automation and Efficiency
• Safety and Environmental Monitoring
• Research and Development
• Regulatory Compliance
DISADVANTAGES OF INSTRUMENTATION IN
PHARMACEUTICAL INDUSTRY
• High cost
• Complexity
• Limited versatility
• Sample preparation requirement
• Maintenance and downtime
• Limited accessibility
• Technological advancement
CONCLUSION
• In summary, pharmaceutical instrumentation is essential
throughout the entire pharmaceutical lifecycle, from drug
discovery to manufacturing, quality control, and research.
• It ensures the safety, efficacy, and quality of pharmaceutical
products, contributing to the overall healthcare and well-being
of patients
THANK YOU
