ALTITUDE
PHYSIOLOGY
OBJECTIVE:
Manage the physiological effects of altitude
Physical Divisions of the Atmosphere
1200 miles
EXOSPHERE
600 miles
IONOSPHERE
50 miles
STRATOSPHERE
Tropopause
TROPOSPHERE
Sea level to flight level 300 -
600 depending on temperature,
MOUNT EVEREST 29,028 FEET latitude and season.
Physiological Zones of the Atmosphere
SPACE EQUIVALENT ZONE: 50,000 FEET AND ABOVE
50,000
DEFICIENT ZONE: 10,000 TO 50,000 FEET
10,000
EFFICIENT ZONE: SEA LEVEL TO 10,000 FEET
Composition of Air
78 % Nitrogen (N2)
21 % Oxygen (O2)
1 % Other
(.03 % CO2)
Sea Level Pressure
14.7
PSI
760 mm Hg
OR
29.92 in. Hg
lbs
Scale Barometer / Altimeter
PERCENT COMPOSITION OF
THE ATMOSPHERE REMAINS
CONSTANT
BUT PRESSURE
DECREASES
WITH ALTITUDE
SIGNIFICANT PRESSURE ALTITUDES
ALTITUDE PRESSURE
FEET mm/HG ATMOSPHERES
0 760 1
18,000 380 1/2
34,000 190 1/4
48,000 95 1/8
63,000 47 1/16
21%
1%
Ot
O2
he
r
78% N2 Partial Pressure
(Dalton’s Law)
760 mm Hg
47 --- mm/Hg
95 ---
190 ---
380 ---
523 ---
760 ---
(Dalton’s Law)
The pressure exerted by a
mixture of gases is equal to the
sum of the partial pressures of
each gas in the mixture.
Pt = P1 + P2 + ...+ Pn
CIRCULATION
FUNCTIONS OF THE
CIRCULATORY SYSTEM
Oxygen and nutrient (fuel) transport to the cells.
Transport of metabolic waste products to organ
removal sites.
Assists in temperature regulation.
Components of the
Circulatory System
Blood transport of O2 and CO2
O2 Plasma
CO2
CO2
O2
CO2 O2
hemoglobin
molecule O2 molecule
Red Blood Cell
RESPIRATION
FUNCTIONS OF THE
RESPIRATORY SYSTEM
Intake of Oxygen [O2]
Removal of Carbon Dioxide [CO2]
Maintenance of body heat balance
Maintenance of body acid base balance [pH]
Phases of Respiration
Breathing in Breathing out
Active Phase Passive Phase
INHALATION EXHALATION
CONTROL
OF
RESPIRATION
COMPONENTS OF THE RESPIRATORY SYSTEM
Law of Gaseous Diffusion
Gas molecules of higher pressure move in the
direction of gas molecules of a lower pressure
PO2 = 100mmHg PO2 = 40mmHg
PO2 = 70mmHg PO2 = 70mmHg
Blood Gas Exchange
Venous Capillary
Hemoglobin Saturation 75%
PCO2 = 46 mm PO2 = 40 mm
CO2 Tissue Alveoli CO2
O2
PO2 = 1 - 60 mm PO2 = 100 mm
O2
PCO2 = 46 mm PCO2 = 40 mm
O2 CO2
O2
PCO2 = 40 mm PO2 = 100 mm
Arterial Capillary
Hemoglobin Saturation 98%
Oxygen transport in the blood:
dependent on the
partial pressure of oxygen.
pO2
Correction of Altitude, Alveolar
O2, Hb saturation
-------- ambient air --------
ALTITUDE BAROMETRIC ALVEOLAR HEMOGLOBIN
(FEET) PRESSURE OXYGEN SATURATION
(mmHG) ( PAO2) % (HB)
Sea level 760 104 97
10,000 523 67 90
20,000 349 40 70
30,000 226 21 20
40,000 141 6 5
50,000 87 1 1
Correction of Altitude, Alveolar
O2, Hb saturation
-------- 100% Oxygen --------
ALTITUDE BAROMETRIC ALVEOLAR HEMOGLOBIN
(FEET) PRESSURE OXYGEN SATURATION
(mmHG) ( PAO2) % (HB)
Sea level 760 673 100
10,000 523 436 100
20,000 349 262 100
30,000 226 139 99
40,000 141 58 87
50,000 87 16 15
g !
r n in
L ea
o n
e c k
C h
tes
i n u
0 M
1
Take a
break!
Hypoxia
State of oxygen [O2]
deficiency in the blood cells
and tissues sufficient to
cause impairment of
function.
Types of Hypoxia
Hypemic
Stagnant
Histotoxic
Hypoxic
Hypemic Hypoxia
Inability of the
+ + blood to
accept oxygen
+
+ in
+
+ + adequate
+
+ + amounts
+ +
+
+
+
Stagnant
Stagnant Hypoxia
Hypoxia
adequate Reduced
oxygen
blood
flow
Blood Red blood cells
moving not replenishing
slowly tissue needs
fast enough
Histotoxic Hypoxia
Inability of
adequate
oxygen
the
cell to accept
or use
oxygen
Red blood cells
retain oxygen
Poisoned tissue
Hypoxic Hypoxia
Reduced
pO2
in the
lungs
(high
altitude)
Red
blood cells
Body tissue
Effect of Pressure on
Blood O2 Saturation
pO2 = 34 mm
87% 10,000
10,000FEET
FEET
CO2
O2 Alveolar
AlveolarpO pO22 == 60mm
60mm
% SAT
pO2 = 60 mm O2
Arterial
ArterialpOpO22 == 34mm
34mm
O2 CO2
Press.
Press.Grad.
Grad. == 26mm
26mm
pO2 = 60 mm 60mm Arterial
ArterialSat.
Sat. == 87%
87%
Alveolar pO2
pO2 = 40 mm 98%
SEA
SEALEVEL
LEVEL
CO2 Alveolar
AlveolarpO pO22 ==100mm
100mm
% SAT
O2
pO2 = 100 mm O2 Arterial
ArterialpOpO22 == 40mm
40mm
O2 CO2 Press.
Press.Grad.
Grad. == 60mm
60mm
100mm
Arterial
ArterialSat.
Sat. == 98%
98%
pO2 = 100 mm
Alveolar pO2
Hypoxia
Symptoms
Subjective: Feel
Air
Air hunger
hunger Hot
Hot and
and Cold
Cold Flashes
Flashes
Apprehension
Apprehension Euphoria
Euphoria
Fatigue
Fatigue Belligerence
Belligerence
Nausea
Nausea Blurred
Blurred vision
vision
Headache
Headache Numbness
Numbness
Dizziness
Dizziness Tingling
Tingling
Denial
Denial
Hypoxia
Signs
Objective: See
Hyperventilation
Cyanosis
Mental confusion
Poor Judgment
Lack of muscle coordination
Stages of Hypoxia
Indifferent Stage
Compensatory Stage
Disturbance Stage
Critical Stage
Indifferent Stage
Altitudes
Air: 0 - 10,000 FEET 100% O2:
34,000 - 39,000 FEET
Symptoms:
decrease in
night vision
@ 4000 feet
Compensatory Stage
Altitudes
Air : 10,000 - 15,000 FEET 100% O2:
39,000 - 42,000 FEET
Symptoms: impaired efficiency
drowsiness
poor judgment
decreased coordination
Disturbance Stage
Altitudes
Air: 15,000 - 20,000
FEET
100% O2: 42,000 -
44,800 FEET
Disturbance Stage
symptoms
Sensory Vision
Touch & pain
Hearing
Disturbance Stage
symptoms
Mental Memory
Judgment
Reliability
Understanding
Disturbance Stage
symptoms
Personality Happy Drunk
versus the
Mean Drunk
Disturbance Stage
symptoms
Performance Coordination
Flight Control
Speech
Handwriting
Time off Oxygen
1 minute
2 minutes
3 minutes
4 minutes
5 minutes
6 minutes
put back on oxygen
CAUTION!
CAUTION!
Failure to recognize symptoms
and take corrective action may
result in an aircraft mishap
Disturbance Stage
Signs Hyperventilation
Cyanosis
Critical Stage
Altitudes
Air: 20,000 FEET and
above 100% O2: 44,800 FEET and
above
Symptoms: loss of consciousness
convulsions
death
WARNING!
When hemoglobin saturation falls to
65%
serious cellular dysfunction occurs;
and if prolonged, can cause death
WARNING!
Factors modifying hypoxia
symptoms
Pressure altitude Physical activity
Rate of ascent Individual factors
Physical fitness
Time at altitude Self-imposed stresses
Temperature
it’s a no brainer!
Drugs Alcohol
Exhaustion Tobacco
Hypoglycemia
keep self imposed stresses out of the aircraft
alcohol
alcohol et
f e
00
20
e =
nc B
ou U
1 Z
Z
Expected
Expected Performance
Performance Times
Times
FL 430 & above 9-12 seconds
FL 400 15 - 20 seconds
FL 350 30 - 60 seconds
FL 300 1-2 minutes
FL 280 2 1/2 - 3 minutes
FL 250 3-5 minutes
FL 220 8 - 10 minutes
FL 180 20 - 30 minutes
Expected performance time for a crew member
flying in a pressurized cabin is reduced
approximately one-half following
loss of pressurization such
as in a:
RD
rapid decompression
Hypoxia
Prevention
limit time at altitude
breathing oxygen
pressurized cabin
Hypoxia
Treatment
oxygen
descend to a safe altitude
Hyperventilation
definition
an excessive rate and depth of
respiration leading to the abnormal
loss of CO2 from the blood.
Hyperventilation
Causes
Emotional (fear, apprehension,
excitement)
Pressure breathing
Physical stress
Hypoxia
Hyperventilation
Symptoms
tingling sensations
muscle spasms
hot and cold sensations
visual impairment
dizziness
unconsciousness
Hyperventilation
reason for symptoms:
loss of carbon dioxide [CO2]
shift in pH balance
Hyperventilation
significance
incapacitation of an otherwise
outstanding, healthy aviator.
confusion with hypoxia
Hyperventilation
prevention
Don’t Panic
Control your breathing
Check your oxygen equipment - it may be hypoxia
Hyperventilation
corrective action
above 10,000 feet
possible hypoxia
below 10,000 feet
probable hyperventilation
Let’s take
t e s
inu
0 m
1
a break
Dysbarism
syndrome resulting from the effects,
excluding hypoxia, of a pressure
differential between the ambient
barometric pressure and the
pressure of gases within the body
Boyle’s Law
The volume of a gas is
inversely proportional to its
pressure; temperature
remaining constant.
Gas Expansion
6.0X 43,000 9.5X
4.0X 34,000 5.0X
2.5X 3.0X
25,000
DR
YG 1.8X 16,000 2.0X
IO N
AS NS
EX
PA X PA
N S E
SIO GA
N T
WE
Gas Expansion
prevention of abdominal gas pains
Watch your diet, don’t eat too fast
Avoid soda and large amounts of water just
prior to going to altitude
Don’t chew gum during ascent
Keep regular bowel habits; eat your fiber
Middle Ear
Semicircular canal Cochlea Auditory
nerve
Ear drum
Middle ear
External ear
Eustachian tube Opening
Openingto
tothroat
throat
Pressure Effect
Tympanic Middle Ear Cavity
Membrane
Atmospheric
Pressure
External Ear Clear
Eustachian Tube
Middle Ear Cavity
Tympanic
Membrane
External Ear
Atmospheric
Pressure Ear Block
Eustachian Tube
Blocked / Infected
normal
tympanic
membrane
(ear drum)
inflamed
tympanic
membrane
(ear drum)
infected
tympanic
membrane
(ear drum)
The Sinuses
Frontals
Ethmoids
Maxillary
Sphenoids
Treatment of an Sinus/Ear Block
1. Stop the descent of the aircraft and attempt
to clear by valsalva.
2.If unable to clear, climb back to altitude until
clear by pressure or valsalva.
3.Descend slowly and clear ear frequently
during descent.
Barodontalgia
Tooth pain due to:
Gum abcess: dull pain on ascent
Inflamed pulp: sharp pain on ascent
Inflamed maxillary sinus: pain
primarily on descent
Decompression
Sickness
Henry’s Law
The amount of gas
dissolved in solution is
directly proportional to
the pressure of the
gas over the solution
NG
N I
A R Evolved gas disorders
are considered serious
Wand medical treatment and advice
must be sought immediately.
Evolved Gas Disorders
The Bends
Parathesia
The Chokes
Central Nervous System-CNS
Evolved Gas Disorders
The Bends N2 bubbles become
trapped in the joints.
Onset is mild, but
eventually painful!
Evolved Gas Disorders
N2 bubbles form
Parathesia
along nerve tracts.
Tingling and itchy
sensation and possibly
a mottled red rash.
Evolved Gas Disorders
N2 bubbles block
The Chokes
smaller pulmonary
vessels. Burning
sensation in sternun.
Uncontrollable desire to
cough. Sense of
suffucation ensues.
Evolved Gas Disorders
CNS N2 bubbles affect
spinal cord. Visual
disturbances,
paralysis, one sided
tingling.
Evolved gas factors
Rate of ascent Exercise
Altitude Duration of exposure
Body fat content Repeated exposure
Age
Decompression Sickness
prevention
Denitrogenation
Denitrogenation
100
90
80 Denitrogenation
70
Maintain cabin
60
50 pressurization
40
30
20
10
0
0 1 2 3 4 5
TIME IN HOURS
Decompression Sickness
treatment
Descend Land at nearest
location where
100% Oxygen qualified medical
assistance is
available.
Compression greater
than 1 atmosphere
(absolute).
Scuba Divers Beware!
i c t i o n
re s t r g !!! !!
o u r f l y i n
2 4 H ing a n d
n d i v
tw e e
b e
or be bent!
Thank you !
