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Propofol Injection Uses and Dosage

Propofol is an intravenous sedative-hypnotic most commonly used for inducing and maintaining anesthesia. It is used to induce sleep during general anesthesia for surgery or medical procedures in both adults and children over 2 months old. Propofol is also used to sedate critically ill patients requiring mechanical ventilation. It is given through intravenous injection and causes rapid sleep onset. Propofol dosage varies based on factors like age and medical condition. It is contraindicated in those with hypersensitivity to its ingredients or for obstetric procedures due to risk of neonatal depression.

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162 views9 pages

Propofol Injection Uses and Dosage

Propofol is an intravenous sedative-hypnotic most commonly used for inducing and maintaining anesthesia. It is used to induce sleep during general anesthesia for surgery or medical procedures in both adults and children over 2 months old. Propofol is also used to sedate critically ill patients requiring mechanical ventilation. It is given through intravenous injection and causes rapid sleep onset. Propofol dosage varies based on factors like age and medical condition. It is contraindicated in those with hypersensitivity to its ingredients or for obstetric procedures due to risk of neonatal depression.

Uploaded by

NARESH JANDIAL
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PROPOFOL INJECTION

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Introduction:-
 Propofol is an intravenous sedative-hypnotic.

 Most common intravenous agent used for induction and


maintain ace of Anaesthesia.
USES
• Propofol slows the activity of your brain and nervous system.

• Propofol is used to put you to sleep and keep you asleep during general anaesthesia
for surgery or other medical procedures. It is used in adults as well as children 2
months and older.

• Propofol is also used to sedate a patient who is under critical care and needs a
mechanical ventilator (breathing machine).
Available Strength & Documentation
Propofol Injection 10 ml
Propofol Injection 20 ml
Propofol Injection 50 ml
COPP Available

FOR DOMESTIC & EXPORT


HOW IS PROPOFOL GIVEN?

• Propofol is injected into a vein through an IV. A healthcare provider will give you this
injection.

• You will relax and fall asleep very quickly after propofol is injected.

• Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will
be watched closely while you are under the effects of propofol.
DOSAGE & ADMINISTRATION
• Healthy Adults Less than 55 Years of Age: 40 mg every 10 seconds until induction onset (2to 2.5 mg/kg)

• Elderly, Debilitated Patients: 20 mg every 10 seconds until induction onset (1to 1.5 mg/kg)

• Cardiac Anaesthesia: 20 mg every 10 seconds until induction onset (0to 1.5 mg/kg)

• Neurosurgical Patients: 40 mg every 10 seconds until induction onset (1to 2 mg/kg)

• Paediatric – healthy 3 years of age or older: 2to 2.5 mg/kg administrated over 20-30 seconds .
INDICATIONS

• Because of its early induction, early & smooth recovery , inactive metabolism & anti
emetic effects it is the IV agent of choice for day care surgery.

• Along with opioids (alfentanil or remifentanil) it is the agent of choice for total
intravenous anaesthesia(TIVA).

• Propofol Injection can be used to produce sedation in ICU patient.

• Agent of choice for induction in susceptible individuals for induction for malignant
hyperthermia.
CONTRAINDICATIONS

• Hypersensitivity to propofol which contains soyabean,oil and egg phospholipid.


• Obstetrical procedures(Propofol crosses the placenta and maybe associated with neonatal
depression).
• Propofol is not recommended for use in nursing mothers because propofol has been
reported to be excreted in human milk and the effects of oral absorption of small amounts
of propofol are still known.
• Propofol not recommended for children below the age of 3 years because safety and
effectiveness have not been established yet.
THANK YOU

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