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Respiratory Function in Anesthesia: Ruby Anne D. Batobalonos, M.D Anesthesia Pre Resident

The document discusses respiratory function in anesthesia. It covers topics like the oxygen cascade, oxygen and carbon dioxide transport, ventilation and perfusion distribution and control, physiologic dead space, physiologic shunt, and the oxygen-hemoglobin dissociation curve.

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Bhi-An Batobalonos
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132 views17 pages

Respiratory Function in Anesthesia: Ruby Anne D. Batobalonos, M.D Anesthesia Pre Resident

The document discusses respiratory function in anesthesia. It covers topics like the oxygen cascade, oxygen and carbon dioxide transport, ventilation and perfusion distribution and control, physiologic dead space, physiologic shunt, and the oxygen-hemoglobin dissociation curve.

Uploaded by

Bhi-An Batobalonos
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

Respiratory Function in

Anesthesia

Ruby Anne D. Batobalonos, M.D


Anesthesia  Pre Resident 
General objective
• to discuss on respiratory function in anesthesia
• Specific objectives
• steps in oxygen cascade
• Oxygen and carbon dioxide transport
• Distribution of ventilation and perfusion
• Control of ventilation and perfusion
• Physiologic dead space
• Physiologic shunt
• Oxygen-hemoglobin dissociation curve
OXYGEN CASCADE ( step 1-2)
OXYGEN CASCADE ( step 3-4)
OXYGEN CASCADE ( step 5-7)
Oxygen-hemoglobin dissociation curve
• Hb molecule consists of four heme molecule attached to a globin molecule
• Each heme molecule consist of :
• glycine ,
• α-ketoglutaric acid
• Iron in ferrous form ( ++ )
• Hb is fully saturated by a PO2 of about 700 mm Hg
• This curve relates the saturation of Hb to PaO2
• PaO2 = 90 -100 SaO2=95-98
• PaO2 = 60 SaO2=90
• PVO2 = 40 SVO2 =75
• the oxyhaemoglobin dissociation curve describes the relation
between the partial pressure of O2 (x axis) and the oxygen saturation
(y axis).
Effect of CO2 Concentration
Hemoglobin has a reduced affinity for oxygen in the presence of CO2.
The greater the concentration of carbon dioxide, the more readily the
hemoglobin releases its oxygen (the Bohr effect).
• Left shifted O2-Hb curve • Right shifted O2-Hb curve P50
P50 < 27 > 27
• Acidosis
• Alkalosis • Hyperthermia
• Hypothermia • Increased 2,3 DPG
• Abnormal & fetal Hb • Abnormal Hb
• Decreased 2,3 DPG • Inhaled anesthetics
old blood containing citrate ,
1 MAC isoflurane shifts P50 to right 2.6 +
dextrose
0.07 or -0.07
(adding phosphate minimizes
changes) • Narcotics have no effect on the curve
References:
• Clinical anesthesia 8th edition , Paul Barash
• Hagberg and Benumof’s Airway management
Thank you!

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