Formulation Project Report
Suspension Paracetamol
By :
Aisye Eka Putri
Farah Hildy Fih
Rizka Nurhalisya
Yuni Nur Rahmawati
INTRODUCTION
● Paracetamol, also known as
acetaminophen, is a medication used to
treat fever and mild to moderate pain. At
a standard dose, paracetamol only slightly
decreases body temperature; it is inferior
to ibuprofen in that respect, and the
benefits of its use for fever are unclear.
INTRODUCTION
● According to The International
Pharmacopoeia, Paracetamol oral suspension
is a suspension of Paracetamol in a suitable
vehicle, which may be flavoured. It contains
not less than 90.0% and not more than
110.0% of the amount of paracetamol
(C8H9NO2) stated on the label.
INTRODUCTION
● Additional information Strength in the
current WHO Model list of essential
medicines: 125 mg per 5 ml (25 mg per
ml). Strength in the current WHO Model
list of essential medicines for children: 125
mg per 5 ml (25 mg per ml).
SUSPENSION PARACETAMOL
PROJECT
This recipe is categorized for children Category. Non-
opioid analgesic Storage Paracetamol oral suspension
should be kept in a well-closed container having a
child-resistant closure, protected from light.
Netto: 100 ml
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Methods and material
SPOKEN WRITTEN
LANGUAGE CERTIFICATE
LEVEL LEVEL
SPANISH 9/10 9/10 Advanced
GERMAN 6/10 7/10 Intermediate
FRENCH 8/10 8/10 Advanced
Methods
1. balance the scales, weigh the ingredients in the recipe
2. calibrate the bottle
3. Cook the water to a boil, then wait until the temperature reaches (±80° 𝑐)
4. Develop CMC Na over hot water (±80°𝑐) by sprinkling it evenly, then wait (±15 )
5. In another mortar, grind the paracetamol ad finely, then add tween 80, grind ad homogeneously.
[Link] propylene glycol to the pct+tween 80 mortar, grind ad homogeneously (mixture I)
7. Crush the CMC Na that has been developed ad mucilage
8. Put the mucilage into the mixed mortar (1), grind it to form a corpus suspension
9. Add syrup simplex into the mortar, grind ad homogeneous
10. Dilute with aquadest, then put into a bottle
11. Add aquadest ad calibration limit
12. Cover the bottle, shake ad homogeneous
RESULT AND DISCUSSION
The paracetamol suspension was mixed homogeneously. which opposes the
slightly cloudy nature of the suspension and there is a precipitate from the
formation of paracetamol and Na CMC.
In the result of suspension there is foam which is quite disturbing the appearance
of the suspension, This is due to the saponification of the tween 80 substance.
except if the foam is filtered before packaging.
Tween 80 has HLB 15, which is a detergent and solubilizing agent. tween 80 also
causes the suspension to become clear because the paracetamol is completely
dissolved.
Test result data
1ST TRY 2ND TRY 3RD TRY
Conclusion
Results of our research were compared with conditions, respectively criteria, set by
International Pharmacopeia, respectively British Pharmacopeia (BP) and Indonesia
Pharmacopeia.
it can be concluded that the formulation in the recipe is not a paracetamol suspension
formulation, but a paracetamol syrup formulation.
in some experiments there was a change in viscosity and pH.
This shows that the suspension made does not meet the requirements for circulation and
consumption
THANK YOU!
