Scribd
Upload
96 views14 pages

Polymers Role in CDDS: Prepared By: Mr. Lalit Rana

Polymers play an important role in controlled drug delivery systems (CDDS). Polymers are large molecules made up of repeating small monomer units that can be natural or synthetic. They are used in various CDDS to control the rate and duration of drug release. Some examples include using polymers in transdermal patches, oral delivery systems that release drugs through osmotic pressure or gel diffusion, and ocular inserts that use mucoadhesive polymers to prolong drug contact with the eye surface. Polymers allow the development of CDDS that can improve drug absorption and patient compliance by providing sustained drug levels over time.

Uploaded by

Shubham Srivastava
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
96 views14 pages

Polymers Role in CDDS: Prepared By: Mr. Lalit Rana

Polymers play an important role in controlled drug delivery systems (CDDS). Polymers are large molecules made up of repeating small monomer units that can be natural or synthetic. They are used in various CDDS to control the rate and duration of drug release. Some examples include using polymers in transdermal patches, oral delivery systems that release drugs through osmotic pressure or gel diffusion, and ocular inserts that use mucoadhesive polymers to prolong drug contact with the eye surface. Polymers allow the development of CDDS that can improve drug absorption and patient compliance by providing sustained drug levels over time.

Uploaded by

Shubham Srivastava
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
You are on page 1/ 14

Polymers Role in CDDS

Prepared by:
Mr. Lalit Rana
Polymer
The word “polymer ” means
parts.”
“many A polymer is a large
molecule made up of many small
repeating units.
Polymers are considered to be a
subset of macromolecules.
Macromolecule refers to any large
molecule.
A monomer is a small
that
moleculecombines with other
molecules of the same or different
types to form a polymer.
DEFINITION
Polymers are very large molecules made when hundreds of monomers join together to
form long chains

The word ‘polymer ’ comes from the Greek words poly


(meaning
‘many’) and meros (meaning ‘parts’).

Example: POLYBUTADIENE =
(BUTADIENE+ BUTADIENE+......)n
Where n = 4,000
CHARACTERISTICS OF IDEAL
POLYMER
1. Low Density.
2. Low coefficient of friction.
3. Good corrosion resistance.
4. Good mould ability.
5. Excellent surface finish can be obtained.
6. Can be produced with close dimensional tolerances.
7. Economical.
8. Poor tensile strength.
9. Low mechanical properties.
10. Poor temperature resistance.
11. Can be produced transparent or in different colours
Classification Of Polymers
Natural Polymer
1. Protien-based polymer: Collagen, Albumin,
Gelatin
2. Polysaccharides: Alginate, Cyclodextrin, Chitosan, Dextran, Agarose, Hyaluronic acid, Starch,
Cellulose

Synthetic Polymers

Biodegradable Polymer
a) Polyester: Poly lactic acid, Poly glycolic acid Poly hydroxyl butyrate,
Polyester, Polycaprolactone Poly lactide-co-glycolide (PLGA), Poly diaxonone

b) Polyanhydride: Poly adepic acid, Poly sebacic acid Poly terpthalic


acid
c) Polyamides: Poly amino acid, Poly imino carbonate
d) Phosphorous based polymer: Polyphosphates, Poly phosphonates, Poly
Phosphazenes
e) Others: Poly cyanoacrylates, Poly urethanes, Poly ortho ester, Polyacetals
etc. Non-Biodegradable polymers
a) Cellulose derivative: Carboxy methyl cellulose, Ethyl cellulose Cellulose acetate
hydroxyl propyl methyl cellulose

b) Silicons: Polydimethyl siloxane, Colloidal silica, Polymethacrylate, Polymethyl


methacrylate c) Others: Poly vinyl pyrolidine, Ethyl vinyl acetate, Poloxamine etc.
Applications of Polymers for Controlled
Drug Delivery
1. The Ocusert
System
The delivery of therapeutic agents to the eye
for the treatment of disorders of the eye, (e.g.,
glaucoma), using conventional drug delivery
systems, e.g., drops, ointments, is an inefficient
process.

The efficiency of ocular drug delivery is


improved through the use of polymeric
implants that are implanted under the lower
cul-de-sac of the eye. In this system pilocarpine
is dispersed within an alginic acid matrix which
is sandwiched between two layers each
composed of poly(ethy1ene-co-vinyl
It is designed to release either 20 µg/h or 40
acetate).
µg/h of a therapeutic agent for a seven day
period following implantation.
2. Transdermal Patches
Transdermal drug delivery involves the
diffusion of the drug through the skin and
ultimately absorption into the systemic
circulation.
The drug delivery system is composed of
several layers, namely a metallic backing
layer, which is impermeable to drug diffusion
thereby preventing drug loss, the drug
containing reservoir, a rate controlling
membrane and an adhesive layer.

In the matrix drug is dissolved or dispersed


with solid polymer (acrylate co-polymer).
3. ORAL DRUG DELIVERY SYSTEM:

Here, the drug gets released at controlled rate when administered


orally. For that several mechanisms are involved.
a) Osmotic pressure controlled GI delivery system
b) Gel diffusion controlled GI delivery system
c) Muco-adhesive GI delivery system
a) Osmotic pressure controlled GI delivery system:
b) Gel diffusion controlled GI delivery system
c) Muco-adhesive GI delivery system
4.Ocular Drug Delivery System

• Itallows prolonged contact of drug with


corneal surface of eye. The example for ODDS
is pilocarpine in the treatment of glaucoma. In
this muco-adhesive polymers are used as
barriers to control the drug release.
• E.g.
Polyacrylic acid
Co polymers of acetate vinyl & ethyl

You might also like