ALDA RISMA CASE
SURYA WILIA
0911011017
FAKULTAS FARMASI
UNIVERSITAS ANDALAS
VICTIM
ANAMNESA
1. Alcohol consumer
2Often use ba. rbiturate at the same time with alcohol
3. Using drug which make slender of type of
amphetamine and metamphetamine by injection
Drug list which is used before her death
Amphetamine
Barbiturate ( Dormicum )
OMZ ( omeprazol)
Neurobium
Diazepam
Propovol
RESULT OF VISUM CORPSE VICTIM
o In stomach : liquid shabu
o At kidney and bile : morphine
o At urine : and amfetamin of metamfetamin high rate
o At body was found propovol and benzodentin that
was represented the root cause death
PHARMACOKINETICS OF
DORMICUM ( MIDAZOLAM)
Activity of this medicine is quick that is in 30 minute
and stay until 5-7 hours. Midazolam was bound
plasma protein counted 96%.Reorganizing allows
quickly and perfection ( 60-80%) becoming final
metabolite 1-hydroksimethyil-midazolam which is
released to pass urin in the form of glukuronida.
plasma of T 1 / 2 - its very short that is 1,5-2,5
[hours of metabolit finally 60-80 minute
DOSES
Barbiturate : 7,5-15 mg ( maleat)
local Anaesthesia Pramedication : oral 25 minute
mg45 ; 1ntramuskular 5 mg ( chloride)
Side Effects : if exceeding dose above can cause
resistance in respiration of which can become fatally
PHARMACOKINETICS OF
OMEPRAZOL ( OMZ)
Blocking of acid exretion do not depended from
plasma rate, but from surface under curve ( AUC). Its
Reabsorption is complete, for 2-5 hours. It has high
Protein plasma ( 95%), t1/2 plasma its only more or
less 1 hour but its activity stay 24 hour. At heart, this
substance is reorganized entirely become inactive
metabolites, which is excreted by urine to 80%.
Between blood and its effect do not have
correlation.
Omeprazol ravelled in acid atmosphere so that
require to be given by acid proof cladding.
Side effects : head pain, muscle pain, sleepless,
Eliminasi of and diazepam of fenitoi pursued
PHARMACOKINETICS OF
DIAZEPAM
AT USAGE OF ORAL AND IN CLYSMA, ITS
REABSORPTION IS GOOD AND QUICKLY, BUT
IMPERFECT AND SLOW IN THE FORM OF
SUPPOSITORIA. ABOUT WAS BOUND WITH
PLASMA PROTEIN. IN LIVER, WAS CHANGE
DIAZEPAM BECOME N-ACEHYILDIAZEPAM WHICH
IS ACTIVE ALSO WITH PLASMA OF T ½ IS LONG,
THAT IS ABOUT 42-120 HOURS. T ½ PLASMA
DIAZEPAM ONLY RANGING FROM 20-54 HOURS.
PHARMACOKINETICS OF
PROFOLOL
Blocking of acid exretion do not depended from
plasma rate, but from surface under curve ( AUC). Its
Reabsorption is complete, for 2-5 hours. It has high
Protein plasma ( 95%), t1/2 plasma its only more or
less 1 hour but its activity stay 24 hour. At heart, this
substance is reorganized entirely become inactive
metabolites, which is excreted by urine to 80%.
Between blood and its effect do not have
correlation.
ANALYSIS CASE
•Consumption barbiturate which have long time with at
the same time alcohol will improve barbiturate activity
which caused poisoned
•Usage of alcohol in a state of empty stomach can
improve acid of gastric and to decrease it, was given
omeprazol. This drug can degrade acid quickly and
strongly by resistance pump proton.
•Usage of drug which made slender contains
amfetamin and metamfetamin will stimulate
CNS, increase heart frequency and blood
pressure.
•represent symptom of hipoksia. To overcome
recuring Usage of this amfetamin caused
tolerance
because condition of overdosis, arise painful
and spasm then is given neurobion, but it is
not effective.
Giving high dose of diazepam ( 400 iv mg). It can
more serious condition of hipoksia and cause to
desist breath at once
