ASTHMA IN CHILDREN
presented by Mbekeka Angella
presented by Mbekeka Angella
Defnition
Asthma is a chronic inflammatory disease of the
airways. Symptoms range from mild to severe,
intermittent to chronic.
Untreated or under treated, asthma can lead to severe
respiratory distress and in rare cases, sudden death.
It can be classified into acute and chronic asthma.
presented by Mbekeka Angella
GENERAL SIGNS AND SYMPTOMS OF
ASTHMA
Wheezing
Chronic or recurrent cough
Tight feeling in the chest
Shortness of breath
Rapid breathing
Nasal flaring
Anxiety
Feeling weak or tired
presented by Mbekeka Angella
Risk factors for developing asthma
A family history of allergy, eczema and asthma
Smoking in the home.
House dust and dust mites.
Premature Births < 36 weeks of gestation.
Presence of Pets in families
presented by Mbekeka Angella
Triggers:
Allergic- such as dust mites
Non-allergic- such as exercise, viral infections, smoke or
other irritants.
These triggers cause inflammation and afterwards,
tightening of the airway muscles.
Only those with allergic asthma have symptoms triggered
by allergens such as pet dander, pollen and dust mites.
About 80- 90 % of adults with asthma have allergic
triggers.
presented by Mbekeka Angella
Cont
The body attempts to expel the allergen/s by releasing
several chemicals including histamines, causing
sneezing, runny noses, watery eyes and broncho-
constriction.
Histamines cause bronchial smooth muscles to
contract which in turn, makes exhaling more difficult.
In a child with asthma, histamine can also trigger
asthma symptoms.
presented by Mbekeka Angella
Pathophysiology
Incase of a trigger factor for example allergens the
body tries to produce chemical histamine which brings
about a running nose, watery eyes and Broncho
constriction. These histamines in excess cause smooth
muscles of the bronchus to constrict making exhaling
very difficult bringing about a difficult in breathing,
wheezing etc.
There excess histamine release in the body tend to
exacerbate asthma attacks.
presented by Mbekeka Angella
Acute severe asthma. (STATUS
ASTHMATICUS)
Clinical diagnosis is defined by increasingly severe
asthma not responsive to drugs that are usually
effective.
presented by Mbekeka Angella
Features of acute severe asthma
Cyanosis or SaO2<92%.
Severe chest retractions and use of accessory muscles.
Inability to talk in an older child.
Silent chest on auscultation (minimal air exchange).
Pulsus paradoxicus >20mmHg (the difference in
systolic arterial blood pressure in inspiration and
expiration doesn’t normally exceed 10mmHg).
Lethargy or changes in mental status.
Hypercapnia (CO2 retention-PaCO2
>50mmHg/>7kpa.
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Management
Before specific therapy the patient must be given high
flow oxygen.
Subcutaneous adrenaline 0.01ml/kg/dose (max 0.3ml)
can be repeated twice, 20min apart.
Nebulised salbutamol or albuterol given every 3hrs.
IV hydrocortisone 6mg/kg/dose 6hrly for 24hrs.
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Management -cont
IV aminophyline 6mg/kg as a loading dose and then
5mg/kg/dose every 6hrs or 1mg/kg/hr. watch out for
signs of toxicity like tachycardia, vomiting,
arrhythmias.
Prednisolone orally 1-2mg/kg/day for 5 days.
No sedation should be given even if the child is
restless.
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Supportive therapy
Give oxygen at a concentration of 100%. Remember
all children with severe asthma are hypoxic. The SaO2
should be >95%.
Maintain hydration by IV fluids or NGT.
Antipyretics should be given if the child is febrile.
Antibiotic should be considered if particularly the
child has a high temperature or localizing signs on
CXR.
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Investigations
FBC
Oxygen saturation, capillary or arterial blood gases..
Blood chemistry- Na, K, Cl, bicarbonate, and glucose.
Chest X-Ray.
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Cautions
If despite the above treatment the child’s condition
does not improve or worsens, then refer immediately
to the intensive care ward for intubation and artificial
ventilation.
Remember that all that wheezes is not only asthma.
Consider other possibilities if it is the first episode and
response is poor.
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Complications
Pneumothorax .
Lung collapse.
Mediastinal empysema.
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Follow up
Continue oral steroids at discharge for a total of 5
days.
Metered dose inhaler of β2 agonists for mild
attacks.
Home nebuliser for moderate asthma attacks.
Inhaled steroids or sodium chromoglycate if the
child has recurrent admissions for severe asthma.
Counselling of the child about precipitating factors
(e.g. pollution, smoking, dust), explain drug
management and when they should bring their
child to hospital (e.g. signs of severe distress: baby
not breastfeeding, child unable to talk.)
presented by Mbekeka Angella