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History of Toxicology Timeline

The document provides a timeline of the history and development of toxicology from prehistory to the present. Some key points: - Ancient Egyptians and Greeks had empirical knowledge of natural poisons and their effects as described in texts like the Eberes Papyrus from 1500 BC. - The concept of dose differentiating a poison from a remedy was established by Paracelsus in the 15th century. - Mateo Orfila published the first toxicology "encyclopedia" in 1787, helping to establish toxicology as a science through experimental studies of poisons, antidotes, and how poisons are transported in the body. - Toxicology continues to develop

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Daniel Salas Ojeda
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40 views18 pages

History of Toxicology Timeline

The document provides a timeline of the history and development of toxicology from prehistory to the present. Some key points: - Ancient Egyptians and Greeks had empirical knowledge of natural poisons and their effects as described in texts like the Eberes Papyrus from 1500 BC. - The concept of dose differentiating a poison from a remedy was established by Paracelsus in the 15th century. - Mateo Orfila published the first toxicology "encyclopedia" in 1787, helping to establish toxicology as a science through experimental studies of poisons, antidotes, and how poisons are transported in the body. - Toxicology continues to develop

Uploaded by

Daniel Salas Ojeda
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

ENVIRONMENTAL

TOXICOLOGY
UNIVERSIDAD MANUELA BELTRAN
INGENIERIA AMBIENTAL
2018
Understanding Toxicology-
Time Line

Prehistory
Prehistory 1500
1500 bC
bC V
V bC
bC 82
82 bC
bC 1
1 aC
aC 1493
1493 1787
1787 Today
Today
Prehistory

Empirical knowledge of poisons


Use of substances of nature as poisons
1500 bC- Eberes Papyrus
 Contains the most voluminous record of ancient
Egyptian medicine known
 The scroll contains some 700 magical formulas
and remedies. It is also evidence of a long
tradition of empiricism
 Describes poissons and natural products for
healing diseases.
1. Hemlock 2. Aconite
V century bC- Hypocrates
 Describes some substances
as poisons; and studied the
overdose effects.
82 year bC- LEX CORNELIA
 Romans and Greeks had a good undertanding of poisoning
applications, even penal applications.
 The Lex Cornelia was the firs law to regullate poisonnings.

Socrates drinking the


hemlock. Illustration from
Cassell's Illustrated Universal
History by Edward Ollier
(1890).
1 bC- Dioscorides
Greek pharmacologist and physician wrote the Materia
Medica, which is the basis for the modern pharmacopeia.
 Described and draw of several poisons.
 Understanded substances frome its origins: animal, vegetal
or mineral kingdom,
1493- Paracelsus
 Swiss German philosopher, physician, botanist, astrologer,
and general occultist.
 Experimentation is needed to know and to understand the
response
 “All the substances are poisons: there is none
which is not a poison. The right dose differentiates
a poison from a remedy”
1787- Mateo Orfila

 Published the first toxicology “encyclopedia” pretending to


unify toxicology knowledge and to diminish the perception of
the relationship btw magic, witchery and this new science.
 Created experimental toxicology.
 Started the study of the antidotes.
 Described the transport of the poison inside the organism
Some Events…
 Great Smog of London
https://www.youtube.com/watch?v=k6Ww0ONdhg4

Dioxin poisoning of Viktor Andriyovych Yushchenko


“THE DOSE MAKES THE POISON”
nontoxic
Too much of a
chemicals can be
good thing can be
toxics at high
bad
doses

Highly toxic
Poisons are not
chemicals can be
harmful at a
life saving when
sufficiently low
given in
dose
appropiate doses
FROM POISON TO POTION: Toxins
turned into life-saving drugs

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