MANAGEMENT OF
DROPPED NUCLEUS
CHAIRMAN
P R O F D R . D I PA K K U M A R N A G
P R O F E S S O R A N D H E A D, R E T I N A
D E P T, N I O & H
M O D E R ATO R
D R . M D. H A F I Z U R R A H M A N
A S S I S TA N T P R O F E S S O R , R E T I N A D E P T,
NIO&H
PRESENTER
DR. SOHEL MAHMUD
F C P S PA R T- 1 1 S T U D E N T, N I O & H
WHAT IS NUCLEUS DROP?
Loss of a part or the whole lens nucleus in the vitreous cavity
MECHANISM OF NUCLEUS DROP
Large posterior capsular tear
More rarely- following zonular dialysis
WHY NUCLEUS DRIFT TOWARDS
VITREOUS CAVITY ?
Researcher Robert Osher
Experiments on cadaveric eyes
If vitreous undisturbed- it will give support
Older vitreous – due syneresis – allow easier passage of nucleus
into posterior segment
High aspiration and post-occlusion surge – pull supporting vitreous
towards PHACO tip - allowing nucleus drop
INCIDENCE
British Ophthalmological Surveillance (BOSU)
The Incidence of nucleus drop following a posterior capsular tear is
0.3% (2-3/1000)Operations/year for Phacoemulsification Surgery
RISK FACTORS
PREOPERATIVE
Increasing age Previous vitrectomy
Pseudoexfoliation Marfan's syndrome
Brunescent/white cataract Posterior polar cataracts
Previous trauma Trainee surgeon
Glaucoma
Tamsulosin use
Small/large eye
RISK FACTORS CONT…
INTRAOPERATIVE
Visible tears in the posterior capsule
Occult tears of the posterior capsule
Radial progression of an anterior capsular tear
Equatorial or posterior rupture of the capsule by the PHACO tip
Posterior capsule torn by an instrument
Zonular dialysis larger than 3 clock hours
COMPLICATION OF DROPPED NUCLEUS
Intraocular inflammation (uvetis/vitritis)- 70%
Secondary glaucoma – 50%
Corneal edema – 35%
Retinal detachment – 1.5%
Choroidal effusion – 4.5%
Cystoid macular edema – 3%
SIGNS OF IMPENDING NUCLEAR DROP
Runaway capsulorrhexis
“Pupil snap” sign
Difficulty in rotation of nucleus
Nuclear tilt
Receding nucleus
MANAGEMENT OF DROPPED NUCLEUS
DEPENDS ON-
The stage of the operation
The amount of the lens fragment dropping into vitreous
Whether vitreoretinal surgical help is available
PRIMARY MANAGEMENT BY THE
ANTERIOR SEGMENT SURGEON
At this point, the situation is still entirely salvageable. So, stay calm.
Resist the urge to chase after the dropped fragments
Move the nuclear fragments to a safe position if possible
Use ophthalmic viscosurgical device to freeze the frame
Avoid unnecessary manipulation
Allow time to reassess the situation
Residual nuclear material should be removed by either
phacoemulsification or converting to an ECCE technique
If phacoemulsification – low bottle height and moderate vacuum
Cortical aspiration by low flow irrigation-aspiration or dry aspiration
Vectis delivery for cases convert to ECCE
Bimanual vitrectomy
Secure the wound
BIMANUAL ANTERIOR VITRECTOMY
It should be performed through the two paracentesis avoiding the use
of the main incision
Using a Low Bottle height, High Cut rate and low Suction, the anterior
chamber should be cleared of Vitreous
Triamcinolone acetonide can be use for better visualization of vitreous
to ensures thorough vitrectomy
The cutter is first passed through the rent in posterior capsule to
remove adequate vitreous
This will ensure removal of all prolapsed vitreous in the anterior
chamber and prevent further vitreous prolapse and the
enlargement of PCR
IOL IMPLANTATION CONTROVERSY
• BOSU data suggest-all IOLs inserted at the time of cataract surgery,
77% were removed or replaced upon subsequent PPV
• Most vitreoretinal surgeons currently agree that placement of a secure
IOL at the time of primary surgery is advisable as long as it is stable
IOL IMPLANTATION OPTIONS
Key points before taking decision to implant IOL during
primary surgery-
Integrity of capsular bag and capsulorrhexis margin
Location and size of posterior capsular tear
Degree of visibility permitting an accurate assessment of capsular
integrity
Size and hardness of dislocated lens fragment
Visibility is too poor or lack of capsular support or hard nuclear
fragments have dislocated - postpone IOL implantation
Visibility is good, PCR is small- conversion to posterior continuous
curvilinear capsulorrhexis (PCCC) is feasible - a single piece PCIOL
can be placed in the bag
PCR is large/peripheral- a PCCC is not feasible - visibility is good -
capsulorehexis margin is intact - after adequate anterior vitrectomy- a
three piece PCIOL can be implanted in the sulcus with optic capture
POST-OPERATIVE MANAGEMENT
Post-operative anti-inflammatory medications
Post-operative anti glaucoma medications
Patient counselling
Referral to vitreoretinal surgeon as early as possible
DEFINITIVE SURGERY- PARS PLANA
VITRECTOMY
Surgery done by vitreo-retina surgeon. So, presence of a vitreo-retina
surgeon’s availability in the team cataract surgeons is ideal.
Timing of surgery depends on an individual case bases, vitrectomy for
dislocated nuclear fragments can be delayed upto 3 weeks without
significant difference in the visual outcome.
PRE-OPERATIVE ASSESSMENT
Following information should be provided by anterior segment
surgeon while referring the patient to vitreoretinal surgeon
Amount/type/hardness of retained lens material
Presence/absence of an IOL implant
Assessment of capsular support
Calculated IOL power
Well secured wound
The following factors should be assessed before a definitive
surgery by vitreoretinal surgeon-
Integrity of the cataract wound
Slit-lamp examination to assess corneal clarity, degree of anterior chamber
inflammation and intraocular pressure
Indirect ophthalmoscopy to assess nuclear fragment as well as to exclude
peripheral retinal tears, retinal detachment or choroidal detachment
B-Scan ultrasonography in cases of media haze (corneal oedema or
associated vitreous haemorrhage)
SURGICAL PROCEDURE
A three-port pars plana vitrectomy is the procedure of choice and
standard of care
Hybrid or mixed gauge (23 and 25-gauge) vitrectomy is performed with
a single large port for introduction of fragmatome
STEP 1: PARS PLANA VITRECTOMY
Key points-
Remove all the vitreous from anterior chamber
Intravitreal triamicinolone acetonide could be utilized for better
visualization of vitreous
All the vitreous attachment to the nucleus should be removed
If fragmatome is being used then induction of PVD is must and
vitreous base should be trimmed
STEP 2: REMOVAL OF NUCLEUS
Incase of soft nucleus –
Removed by vitrectomy cutter (low cut rate - 600-800 cuts/minute)
Few drops of PFCL can be used as a cushion
Light pipe can be used to crush the nucleus against the cutter probe
Incase of hard nucleus-
Perform adequate vitrectomy first
Use ultrasonic fragmatome to manage nucleus
Few drops of PFCL can be used as a cushion
Or delivering the nucleus via limbal route
STEP 3: PERIPHERAL EXAMINATION BY INDENTATION
Locate any pre existing breaks
Localize any unknown breaks caused during the surgery
Manage them by barraging them with laser intra operatively
Reducing chances of post operative retinal detachment
VISUAL OUTCOME
Visual acuity of 6/9-6/18 is achieved in 60-80 % cases with dropped
nucleus
Appropriate and timely management can restore good visual outcome
TAKE HOME MESSAGE
THANK YOU