FLORJAT- 30

FLORJAT- 30
Montajat- The First Company in the World to Formulate Florjat- 30 Do a Complete Pharmacokinetic Profile

Papers Accepted for Publication in International Journals e.g. JVPT, and AJVR

Product Sales Turnover- More than USD 1 Million in 2006 Drug of Choice for Salmonella, Pasteurella and E. coli

FLORJAT- 30
Primarily for Poultry Birds (Can be Effectively Used in Mammalian Neonatal Scour) The Latest 3rd Generation Broad- Spectrum Antibacterial Agent Exclusively for Veterinary Use Primarily Bacteriostatic Agent (Bactericidal at higher dosage) Binds to 50s Ribosome, Thus Arresting Protein Synthesis Contains Fluorine Atom- Prevents Plasmid Mediated Resistance Lacks a Nitro Group- Does Not Cause Aplastic Anemia in Humans No Bone Marrow Suppression (Not Reported)

FLORJAT- 30
PHARMACOKINETIC PATH
10.0

1.0

Observed Predicted

0.1 0 5 10 A 15 20 25

Semi- logarthimic Plasma Concentration time profile of Florjat- 30 following single dose (30 mg.kg-1) oral administration in poultry

FLORJAT- 30
PHARMACOKINETIC PARAMETERSParameters Units I II Animal No. III IV V VI MeanSE

Ka Ke t1/2 Ka

h-1 h-1 h

1.57 0.109 0.44

1.77 0.157 0.39

1.58 0.065 0.436

0.77 0.144 0.890

2.44 0.069 0.283

2.03 0.122 0.341

1.690.22 0.11.01 0.46.08

t1/2 Ke
AUC CL/F Tmax Cmax Vd/F

h
g.mL-1.h mL.kg-1.h-1 h g.mL-1 L.kg-1

6.34
90.77 0.33 1.88 8.129 3.03

4.93
82.05 0.36 1.50 9.26 2.32

10.564
116.82 0.25 2.09 6.68 3.59

4.785
113.37 0.26 2.45 11.18 1.83

10.018
122.28 0.24 1.34 7.62 3.57

5.682
85.57 0.35 1.45 8.72 2.87

7.051.05
101.817.19 0.290.02 1.780.17 8.590.63 2.860.28

Conclusion: The time for plasma concentration above 1 g/ml is more than 24 hours. Therefore, Florjat- 30 should be given at a dosage of 30mg/kg to be repeated every 24 hours following oral administration.

FLORJAT- 30
WITHDRAWAL PERIODSl No. Organ
24 hrs 1. 2. 3. 4. 5. Liver Heart Intestine Spleen Lung 0.0340.002 0.0940.005 0.0260.003 0.1340.005 ND

Conc. (mcg/g)
72 hr ND 0.050.006 0.0480.030 0.0790.003 ND 96 hrs ND ND ND ND ND

6.
7. ND not detectable

kidney
Muscles

ND
ND

ND
ND

ND
ND

Tissue concentration (g/g) of Florjat- 30 oral solution following multiple (5) dose (30 mg/kg) oral administration in poultry

FLORJAT- 30
LD 50, IM (Poultry Birds)S.No . 1 2 Group I II Dose(mg.kg-1) 1250 1275 Log dose 3.097 3.106 Dead 0/4 1/4 Dead % 0 25 Corrected 6.25 25 Probit 3.46 4.33

3 4
5 6

III IV
V VI

1300 1325
1350 1375

3.114 3.122
3.130 3.138

1/4 2/4
3/4 4/4

25 50
75 100

25 50
75 93.75

4.33 5.00
5.67 6.57

LD50 of Florfenicol in poultry is 1333.52 mg.kg-1.

FLORJAT- 30

Bioavailability (Poultry Birds)-

96%

Florjat 30%

Usage Recommendations 30mg/ kg bw, Once Daily in Continuous Drinking Water*

Packs Available 1000ml 5000ml

Micojat- L

MICOJAT
Latest Mycoplasmicidal Drug- Tilmicosin

Highly effective on Mycoplasma gallisepticum M. synoviae Enhances Cellular Immunity

MICOJAT

The MIC requirement for Mycoplasma gallisepticum is 0.0125 g/ml. From the above graphs, it is evident that Tilmicosin is highly effective in treating or preventing Mycoplasma at the recommended dosage (Jordan and Horrocks, 1996)

Medication Program
Treatment after vaccination

Treatment*

Day

1-3

23-25

32

35

Vaccination

Lesion score

% Mortality

*Day 1-3 Micojat, Erythromycin, Tylosin and Enrofloxacin Day 23,24,25 Micojat, Erythromycin, Tylosin and Enrofloxacin

* Fax report

* Fax report

* Fax report

MICOJAT
RECOMMENDED USAGE 15-20 mg/kg body weight 3ml MICOJAT per 10 liter of drinking water Preventive Schedule Days 1,2 3 Days 24, 25, 26 (Days 20, 21, 22 for grow- outs @ Day 35) Better results along with Florjat 30 (given on Days 13, 14, 15)

PACK AVAILABLE120ml

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DIAZIN 600

Diazinon 600mg/ ml EC

Fly repellent ANTIMICROBIAL AGENTS

1- 2ml/ ltr water

250ml, 1000ml

COLIJAT WSP GEDOJAT WSP NEOJAT WSP NEOSIN WSP RYTHROCOL WSP

Colistin sulphate 10MIU/ gm Gentamicin 100mg, Doxycycline 100mg/ g Neomycin (as sulphate) 100% w/w Tylosin 700mg, Neomycin 300 mg Erythromycin 200mg, Colistin 500,000IU/ gm Lincomycin 333 mg; Spectinomycin 667mg/ 1.5gm

Salmonellosis and Colibacillosis All bacterial infections and Mycoplasmosis All gram -ve bacterial infections All bacterial infections and Mycoplasmosis All bacterial infections

Oral; 1g/ 20 liters. Oral; 1g/ 2 liters, sid 230g/ MT feed Oral; 1g/ 2 liters, sid Oral; 1g/ 4ltrs, sid

1kg 1kg 1kg, 25kg 1kg 1kg

SPECTOLIN WSP

All bacterial infections and Mycoplasmosis ANTIPARASITIC AGENTS

Oral; 0.75g/ltr, sid

150gm

NICLOX liq.

Niclosamide 75g, Oxibendazole 10g/ ltr

Roundworms, and Tapeworms ANTICOCCIDIAL DRUGS

Oral; 1ml/kg bw, single dose

1ltr

COXURIL liq. MONCOX liq.

Toltrazuril 25mg/ ml Amprolium 250mg/ ml

Coccidiosis Coccidiosis

7mg/ kg bw; sid, 2 days 1ml/ ltr water; for 5- 7 days

100ml, 1Ltr 1 Ltr

Other Leading ProductsPRODUCT COMPOSITION SUPPORTIVES INDICATIONS ADMINISTRATION PACKING

ANTOX Liq. BROMODIL liq. ELECTROJAT MONDIUR MONSEL Liq.

Organic acids, Fe, Live yeast, Prebiotics (MOS) Bromhexine hydrochloride BP 15mg; Chlorpheniramine Maleate BP 10mg; Mint Extract/ ml NaCl 124g, Trisodium citrate dihydrate 103g, KCl 52g, Vitamin C 120g, Glucose qs/ kg Methenamine 950mg, Vit B1 8 mg, Vit B2 1mg, Vit K3 2mg/ gm Vitamin E 20g, Selenium 360mg/ ltr

Toxin Binder, Acidifier, Probiotic, Prebiotic Mucolytic expectorant; bronchodialator; anti- histaminic agent Electrolyte Anti-Heat Stress

Oral; 1ml/ ltr Oral; 1ml/ 3lit.

1Ltr 1Ltr

Oral; 4.5gm/ltr

100gm, 1kg

As diuretic Supplement, Immunostimulant, Mastitis prevention VITAMINS

Oral;1ml/ ltr Oral; 1ml/ 2ltrs

1kg 1Ltr

BK-CHOLJAT MONTA- C

Vit.B1 10 mg, Vit.B2 4.5mg, Vit.B6 10mg, Vit.B12 5g, Vit.PP 50mg, Vit.K3 10mg, Choline 50mg, Ca- D Pantothenate 50mg, Folic acid 2mg/g Vitamin C 100% w/w

Laying performance

Oral; 1g/ 2ltrs

1 kg

Stress, Immunomodulation

Oral; 1g/ 8ltrs

1kg

MONTA- K
MONTA.3 liq.

Vitamin K3 (MSB) 100%

Coccidiosis, cannibalism
Supplement, Heat stress

Oral; 1g/ 2400 chicks

1kg
1Ltr

MONVIT- L liq.

Vit. A, D3, E, C, K, B- complex, Ca, and Amino Acids

General deficiency, to improve FCR, Stress

Oral; 1ml/ltr

1Ltr

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PACKING

AFLABOND CHOLJAT DICLACOX FLAVOJAT L- LYSINE MADURAJAT MONENCOX PELCON PHYTOPHOS PROBAC- BMD ROBECOX SALINOCOX ZINBAC

HSCAS with organic acids Choline chloride 50% and 60% Diclazuril 0.5% granular Flavomycin 8% granular L- Lysine HCl source Maduramicin ammonium 1% granular Monensin 20 % granular Silicate based compounds Phytase 5000 FTU/ g Bacitracin Methylene Disalicylate 10% granular Robenidine 6.66% granular Salinomycin Sodium 12% granular Zinc Bacitracin 10% granular

Toxin Binder, Mold Inhibitor, and Mold Killer Enhanced Laying Performance Coccidiosis Prevention Non- absorbable Antibiotic Growth Promoter Lysine supplementation Coccidiosis Prevention Coccidiosis Prevention Pellet Binder (silicate based; non- lignin) Phosphorus supplementation Growth Promoter, Necrotic enteritis Coccidiosis Prevention Coccidiosis Prevention Non- absorbable Antibiotic Growth Promoter

500g/ MT feed As required 200g/ MT feed 100g/ MT feed As required 500g/ MT feed 450- 550g/ MT 2kg/ MT 100g/ MT feed 200g/ MT feed 450- 550g/ MT 500g/ MT feed 500g/ MT feed

25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs 25kgs

Thanks
Dr. Puneet Agrawal Marketing Manager

For more information, please contact us at:

Montajat Veterinary Pharmaceuticals Co. Ltd.

2nd Industrial City, Dammam 31491, Kingdom of Saudi Arabia Tel: +966- 812 3221, Fax: +966- 812 3112, e- mail: [email protected] Web: www.montajat.biz