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Coronary Atherosclerosis Guide

Coronary atherosclerosis is a build-up of plaque in the arteries that supply the heart. It is caused by inflammation and injury to artery walls over time. Major risk factors include age, family history, hypertension, smoking, inactivity, obesity, abnormal blood lipids, and diabetes. Plaque is made up of fat, cholesterol, and calcium that hardens and narrows the arteries, reducing blood flow. Treatment options include lifestyle changes, medications, angioplasty, and bypass surgery depending on severity. Regular checkups and controlling risk factors can help manage coronary artery disease.

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734 views19 pages

Coronary Atherosclerosis Guide

Coronary atherosclerosis is a build-up of plaque in the arteries that supply the heart. It is caused by inflammation and injury to artery walls over time. Major risk factors include age, family history, hypertension, smoking, inactivity, obesity, abnormal blood lipids, and diabetes. Plaque is made up of fat, cholesterol, and calcium that hardens and narrows the arteries, reducing blood flow. Treatment options include lifestyle changes, medications, angioplasty, and bypass surgery depending on severity. Regular checkups and controlling risk factors can help manage coronary artery disease.

Uploaded by

sanjivdas
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd

Coronary Atherosclerotic

Heart Disease

[Link] LIXIN
Atherosclerosis
 Atherosclerosis is a syndrome
affecting arterial blood vessels. It
is a chronic inflammatory response
in the walls of arteries . It is
commonly referred to as a
hardening or furring of the
arteries. It is caused by the
formation of multiple plaques
within the arteries
Risk Factors for
Atherosclerosis
 Age:
 Male > 45 years
 Female > 55 years or premature
menopause without estrogen replacement
therapy
 Family History of premature
disease
 Male first-degree relative <55 years
 Female first-degree relative < 65 years
Risk Factors for
Atherosclerosis
 Hypertension
 Appears to weaken the artery
wall at points of high pressure
leading to injury and invasion of
cholesterol.
 Cigarette Smoking
 #1 cause of preventable death in
US
 1 in 5 CHD deaths attributable to
Risk Factors for
Atherosclerosis
 Diabetes
 50% of deaths related to
DM is due to CHD
Risk Factors for
Atherosclerosis
 Inactivity
 Sedentary person has 2x
risk for developing CHD as
a person who is active.
Risk Factors for
Atherosclerosis
 Obesity
Risk Factors for
Atherosclerosis
 Abnormal Blood Lipids
 LDL Cholesterol (low density
lipoprotein)

 HDL Cholesterol (high density


lipoprotein)
Risk Factors
Uncontrollable Controllable

•Sex •High blood pressure


•High blood
•Hereditary
cholesterol
•Race •Smoking
•Age •Physical activity
•Obesity
•Diabetes
•Stress and anger
Atherosclerosis

 Plaque is made up of
fat, cholesterol, calcium,
and other substances
found in the blood. 
Over time, plaque
hardens and narrows
your arteries.  The flow
of oxygen-rich blood to
your organs and other
parts of your body is
reduced.  This can lead
to serious problems,
including heart attack,
stroke, or even death.
 Plaque (the
build-up of
lipid/cholester
ol) in the
artery wall
forms as a
response to
injury to the
endothelium
in the artery
wall.
Plaque vulnerability
factors
Intrinsic factors
 Many people are able to manage
coronary artery disease with
lifestyle changes and medications.

 Other people with severe coronary


artery disease may need
angioplasty or surgery.
Treatment:

 Weight Loss
 Low cholesterol, low saturated
fat diet
 Increased physical activity
 Smoking cessation
 Management of Diabetes
 Restricted alcohol use
Medicine
 1. antiplatelet aggregation
Aspirin ,ticlopidine, clopidogrel, GPIIb/IIIa
receptor antagonist

2. regulate lipid
For hypercholesterolemia: Statins,
Cholestyramine, Colestipol, Nicotininc acid;
      For Hypertriglyceridema: Clofibrate.

3 .thrombolysis
streptokinase, urokinase
Angioplasty
Bypass surgery
•Get regular medical checkups.
•Control your blood pressure.
•Check your cholesterol.
•Don’t smoke.
•Exercise regularly.
•Maintain a healthy weight.
•Eat a heart-healthy diet.
•Manage stress.

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