1, Myotonic dystrophy, 2. Haemophilia - A 3, Sickle cell anaemia 4, Crisducchat syndrome G2, DNA sequencing was carried based ‘on the principle developed by 1. Alec Jeffrey 2, Fredletick sanger 3, Watson and Crick 4, Jacob and Monod 63. Gynecomastia is a common feature of 1, Down's syndrome [Link] wofelter’s syndcome 3. Tumor’s syndrome 4, Edward's syndrome 64, Which of the following is a sex- linked recessive disease? 1, Sickle-cell anaemia 2. Myotonic dystrophy 3. Thalassemia 4, Haemophilia 65. Klinofelter’s syndrome can occur when 1, an abnormal ovum with wo allosomes is fertilised by a normal sperm with ¥ allosome. 2, an abnormal ovam with no allosome is fertilised by an abnormal sperm with X andl allosomes. 3. a normal ovum with one allosome is fertilised by an abnormal sperm with no allosome, 4,an abnormal ovuen with two X chromosomes is fertilised by a ‘normal sperm with X allosome 66, The Human Genome Project was, launched in the year 1.1990 2.1993 3.1997 4, 2003 67, Which of the following are the vectors commonly used ia Human Genome Project? 1. cosmids 2, BAC and YAC. 3. retroviruses 4, adenoviruses 68. The enzyme phenylalanine hydroxylase converts 1. tyrosine 10 pheny! puruvate 2, phenylalanine to tyrosine1. male heterogamety 2. haplodiploidy 3. female heterogamety 4, environmental sex determination 76. Given below are two statements: one is labeled Assertion (A) and other is labeled Reason (R). Assertion (A): Two different types of gametes are produced by female birds, in terms of sex chromosomes. Reason (R): Female birds have one ‘z' and one ‘w' chromosome besides the autosomes. [In the light of above statements, choose the comect answer from the options given below. 41. Aand R are true and Ris the correct explanation of A. 2. Aand R are true and R is not the correct explanation of A. 3. Aistrue, Ris false. 4, Both A and R are false. 77. Select the incorrect statement regarding HGP. 1, Th was completed in 2003. 2. It aimed to determine the sequences of the 3 billion chemical base pairs that make up human DNA. 3, It did not involve the sequencing of the genome of any non-human organism. | | | 4. It aimed to addtess the ethical, legal, and social issues that could arise from the project. 78. HBB gene that codes for beta polypeptide of hemoglobin is located on 1. chromosome 11 2. chromosome 12 3. chromosome 16 4. chromosome 21 79. Who discovered 'X body’ (now called X chromosome) in insects? 1. Morgan 2. Mendel 3. Bridges 4, Henking |80. Which of the following most appropriately describes colour blindness? red-green 1. Chromosomal disorder 2. Autosomal recessive disorder 3, X-linked dominant disorder 4, Xolinked recessive disorder |. Tumer’s syndrome is characterised by 1. rudimentary ovaries 2. rudimentary testes 3. gynaecomastia88. A colourblind woman marries aman, whose mother was homozygous for normal vision, What are the chances of their offspring being colourblind? 1, Allher daughters are colour blind. 2. All her sons are colour blind. 3. 50% daughter are normal and '50% are colour blind, 4, 50% of sons are normal and 50% are colour blind. 89. Anormal woman, whose mother is colorblind marries a male with no family history of colorblindness. ‘What will be the possible phenotypes of the offspring? a) Colorblind son and colorblind daughter b) Colorblind son and carrier daughter ©) Normal daughter and normal son d) Normal son and colorblind daughter Choose the most appropriate answer from the options given below. 4. (a) and (b) only 2. (b)and (@) only 3. (@ and (@) only 4, (b) and (c) only 90, ‘[Link] is normal but her father is haemophilic, She married a normal rman. If they have two sons and two daughters, how many of them are most likely to be hemophilic? [Link] 2. Two 3, Three 4, Four - In crisscross inheritance, the X- linked traits are inherited by grandsons from affected males through 1. carrier daughters, 2, affected sons 3. grand daughters 4, normal sons . Shruti and her husband are normal, bbut her father is haemophilic. What is the chance that her daughter is hhaemophilic? 10 2.0.25 3.05 41 . Aman with a certain Mendelian disorder (homozygous) woman, All his five daughters are affected but none of his five sons is affected with the marries a normalAssertion (A): At low oxygen tension, the biconcave disc like RBC change to elongated sickle structure in sickle cell anaemia. Reason (R): The mutant haemoglobin molecule with abnormal B chain undergoes polymerisation under low oxygen tension causing the change in the shape of the RBC from biconcave disc to elongated sickle like structure. In the light of above statements, choose the correct answer from the options given below. 1, Both A and R are true and R is the correct explanation of A. 2. Ais tue but R is false. 3. Ais false but R is true. 4, Both A and R are true but R is not the correct explanation of A. [Link] chromosome of human has two closely linked genes that control globin synthesis? iu 2.16" 3.9% 4,2156 62 68 74 80 91 97 55 61 67 73 79 85 90 96 54 60 66 72 78 84 89 95 53 59 65 7 7 83, 88 94 100} 2 1 52 58 G4 70 76 82 87 93, 99 Zoology Section A 51 57 63 69 7S 81 section B 86 92 98“Assertion (A): At low oxygen tension, the biconcave disc like RBC change to elongated sickle structure in sickle cell anaemia, Reason (R): The mutant haemoglobin molecule with abnormal chain undergoes polymerisation under low oxygen tension causing the change in the shape of the RBC from biconcave disc to elongated sickle like structure. In the light of above statements, choose the correct answer from the options given below. 1. Both A and R ate true and R is the correct explanation of A. 2. Ais true but Ris false. 3. Ais false but Ris true. 4, Both A and R are true but R is. not the correct explanation of A. [Link] chromosome of human has two closely linked genes that control globin synthesis aus 2.168 3.9" 4.21" Physics | Section A | | | | | [Link] (A) : If polar ice melts, then day will be longer. Reason (R) : Moment of inertia increases and thus angular velocity decreases. 1. Aand Rare true and R is not the correct explanation of A. 2, Aand R are wue and Ris the correct explanation of A. 3. Ais true, Ris false. 4, Both A and R are false. [Link] wheels of moment of inertia 3 kgm? and 5 kgm? are rotating at the rate of 600 rpm and 800 rpm respectively in the same direction. If the two are coupled so as to rotate with the same axis of rotation, the resultant speed of rotation will be (in 1pm) 1.725 2.850 3.420 4.630 103.A flywheel of moment of inertia 10 kgm? is rotating at 50 rad/s. It rust be brought to stop in 10 s. ‘What is the required average power ? 1.-250W 2. -625W_4. superouvlation 82, Which of the following was not a goal of HGP? 1, Improve tools for data analysis. 2, Transfer related technologies 10 other sectors 3. Improve the technique of DNA fingerprinting 4, Address ethical, legal, and social issues (ELSI) that may arise from the project 83, ‘The last chromosome sequenced in Human Genome Project was 1, Chromosome 6 2, Chromosome 1 3. Chromosome 22 4, Chromosome 14 84. A disease caused by an autosomal primary non-disjunction is 1. Klinefelters syndrome 2. Tumer’s syndrome 3, sickle cell anaemia 4, Down's syndrome 8S. Cocnorhabditis elegans isa 1. enidarian 2, nematode 3. wematode 4. molluse Section B 8G, Read the following statements about red-green colour blindness and choose the correct option : Statement-A : Itis an autosome linked dominant disorder. Statement-B : The affected male should have an affected father. 1, Both Statement A and Statement B are wrong 2, Both Statement A and Statement Bare true 3, Statement A is correct, Statement Bis wrong 4, Statement A is wrong, Statement Bis comect 87, Select the correct statement with respect to phenylketonuria, 1, The effected individual lacks an ‘enzyme that converts the amino acid tyrosine to phenylalanine. 2. It is an inbom error of metabolism which is inherited as an autosomal recessive trait, 3. Accumnut n of tyrosine in brain results ip mental retardation, 4, Tyrosine is converted into phenylpyruvic acid and other derivatives,3, phenylalanine to phenyl pyruvic acid 4, tyrosine to melanin 69. Which one of the following pedigree chart symbols represents mating between close relatives? -BO® 70. Broad palm with a single palm crease is characteristically observed ina person with 1. thalassemia 2, Down's syndrome 3, Turner's syndrome 4. Klinefetter’s syndrome 71, ‘The process of sequencing the whole set of genome and later assigning, different regions in the sequence ‘with functions is referred to as 1, sequence annotation 2. DNA fingerprinting | [Link] splicing 4, 1DNA technology | 72. ‘The Human Genome Project was a | 13-year project coordinated by the | US. Department of Energy and the 1. Centre for Disease Control 2, Massachusetts Insitute of | Technology 3. Department of Education | 4, National Institute of Health | 73. In HGP, the sequence of chromosome 1 was completed in 1, April 2001 | 2, March 2009 3, May 2006 4, June 2003 | 74, Human Genome Project was closely | associated with the rapid development of a new area in biology called 1. biochemistry 2. bioinformatics 3. biophysics 4 bionics | 75. The type of sex determination in honeybees is.Section A 51. Turmer’s syndrome in human is caused by 1, autosomal aneuploidy 2. allosomal aneuploidy 3. polyploidy 4, haplodiploidy 52. Given below are two statements: one is labeled Assertion (A) and other is labeled Reason (R). Assertion (A): The genetic makeup of the human sperm determines the sex of child. Reason (R): The sperm produced by men have either X or Y chromosome. In the light of above statements, choose the correct answer from the options given below. 1, Ais true but R is false. 2. Ais false but R is true. 3. Both A and R are true and R is the correct explanation of A. 4, Both A and R are true but R is not the correct explanation of A. 53. A human female with Turner's syndrome 1, has 45 chromosomes with XO ZBdisease. The mode of inheritance of the disease is 1, X-linked recessive 2. X-linked dominant 3. Y-linked 4, Autosomal recessive 94, If both the parents are carriers for phenylketonuria, what isthe probability of phenylketonuria in their children? 1, 25% 2.50% 3.75% 4, 100% 95. Gametogenesis does not involve meiosis in 1. male fruitfly 2, male honeybee 3. female honeybee 4, female fruitfly %. = =D,O 6 dood ob hood ‘The given pedigree chart does not represent which of the following disorders? 1, Haemophilia 2, Sickle cell anemia 3. Myotonic dystrophy 4, Phenylketonuria, 97. Read the following statements. Statement syndrome is a chromosomal disorder ‘caused due to trisomy of allosomes. Statement IT: An indi exhibiting Klinefetter’s syndrome has overall masculine development but some feminine development is also expressed. linefelter's In the light of given statements, choose the correct answer from the ‘options given below. 1, Both statement I and If are true 2. Both statement I and Il are false 3. Statement I is true but statement Mis false 4, Statement Lis false but statement Mis true 98, Which of the following is a plant, ‘whose genome is sequenced as a part of HGP? 1. Arabidopsis 2. Ancylostoma 3. Caenorhabditis 4. Drosophila 99, Given below are two statements: one is labeled Assertion (A) and other is labeled Reason (R).2. has one additional X chromosom e 3. exhibits male characters 4. is able to produce children with normal husband 54, The human genome approximately has 1, 3x 10° bp 2.3% 10° bp 3.3x 10° bp 4.3.x 10 bp 55. Which symbol represents a male person in a pedigree analysis chant? 1. Triangle 2, Diamond 3, Circle 4, Square 56, Identify the correct statement with respect to sex determination in honey bees. 1, Females exhibit mitosis to produce gametes. 2, Males exhibit meiosis to produce gametes. 3, Males do not have father but have grandfather. 4, All the fertilised eggs develop into males 57. The goals of Human Genome Project, include identification of all the ‘approximately genes in human DNA. 1, 20,000 — 25,000 2. 2,000 - 2,500 3.14 milion 4.3 billion ‘sa. Expressed Sequence Tags (ESTs) are 1. introns of spit genes 2. genes that are expressed as RNA. 3. noncoding sequences in genome 4, stop codons in mRNA (8. ‘The amino acid in the 6* position of | beta globin chain of normal | haemoglobin molecule is 1. glutamic acid 2. valine [Link] 4, leucine 60. An example of XO type of sex determination is 1. grasshopper | 2. bird | 3. drosophita 4, buman being | | 61. Which of the following is an | ‘autosomal recessive trait?