To bring awareness to human society on various genetic disorders, its inheritance patterns
and to develop the methods, and techniques of fighting against the diseases.
TEXT BOOKS:
1. Michael Goldberg, Janice Fischer, Leroy Hood and Leland Hartwell, “Genetics: From
Genes to Genomes”, 7th Edition. McGraw Hill Education, 2020.
2. Tom Strachan & Andrew Read, “Human molecular genetics” 4th Edition, Taylor & Francis
Group, Garland Science, 2011.
3. Anthony Griffiths; John Doebley; Catherine Peichel; David A. Wassarman, “Introduction to
Genetic Analysis”, 12th Edition. Macmillan Learning, 2020.
REFERENCES:
1. Benjamin A. Pierce, “Genetics: A Conceptual Approach”, 7th Edition, Macmillan Learning,
2020.
2. William S Klug, Michael Cummings, Charlotte A. Spencer, Michael A Palladino & Darrell
Killian, “Concepts of Genetics”, 12th Edition, Pearson, 2019.
3. D. Peter Snustad, Michael J. Simmons, “Principles of Genetics”, 7th Edition, published by
Wiley, 2015.
CO / PO Mapping CO/PSO Mapping
(3/2/1 indicates strength of correlation) 3-Strong, 2 – Medium, 1 – Weak
COs Programme Outcomes (POs) PSOs
P
PO PO PO PO PO PO PO PO PO PO PO PSO PSO PSO
O PSO1
2 3 4 5 6 7 8 9 10 11 12 2 3 4
1
CO 1 2 1 2 1 2 2 3 2
CO 2 2 2 2 2 2 3 2 2 2 2
CO 3 3 2 1 1 2 3
CO 4 2 3 2 3 1 1 2 3 2 3 3 2 1 2
CO 5 3 2 3 2 3 3 2 3 3 1 3 2 3 3 2 3
CO6 3 3 2 3 2 2 2 3 1 2 2 2 3 3 2
CBT372 CANCER BIOLOGY LTPC
3003
COURSE OBJECTIVES:
The goal of this course is to enable the students to
Understand the basics of cancer and cancerous cells
Discuss the significance of carcinogenesis in the development of cancer
Interpret the role of oncogenes and their growth factors
Make understanding on process of cancer metastasis and their dysregulation factors
Gain knowledge on the advancement in cancer treatment
Design the novel drugs to treat cancer or to reduce the effect of carcinogenesis
UNIT I FUNDAMENTALS OF CANCER BIOLOGY 9
Introduction, historical perspective, classification carcinogenesis, cancer initiation, promotion &
progression, pathways of spread- Epidemology Regulation of cell cycle, mutations that cause
changes in signal molecules, effects on receptor, signal switches, tumour suppressor genes,
modulation of cell cycle in cancer, different forms of cancers, diet and cancer. Cancer screening
and early detection, Detection using biochemical assays, tumor markers, molecular tools for early
diagnosis of cancer.
125
UNIT II PRINCIPLES OF CARCINOGENESIS 9
Theory of carcinogenesis, Chemical carcinogenesis, metabolism of carcinogenesis, principles of
Physical carcinogenesis, x-ray radiation-mechanisms of radiation carcinogenesis.
UNIT III MOLECULAR BIOLOGY OF CANCER 9
DNA repair defects and genomic instability in cancer cells. Signal targets and cancer, activation of
kinases; Oncogenes, identification & retroviruses. Detection of oncogenes & proto oncogene
activity. Growth factors related to transformation. Telomerase.
UNIT IV CANCER METASTASIS 9
Clinical significances of invasion, Molecular genetic of metastasis development, stromal
microenvironment and carcinogenesis, dysregulation of cancer, associated genes Clinical
significances of invasion, heterogeneity of metastatic phenotype, metastatic cascade, basement
membrane disruption, three step theory of invasion, proteinases and tumour cell invasion.
UNIT V ADVANCES IN CANCER THERAPY 9
Different forms of therapy, chemotherapy, radiation therapy, detection of cancers, prediction of
aggressiveness of cancer, advances in cancer detection. Use of signal targets towards therapy of
cancer; Gene therapy. Recent technology to detect cancer diseases and advanced technology to
cure cancer diseases. Targeted drug delivery methods to cure cancer.
TOTAL: 45 PERIODS
COURSE OUTCOMES (CO):
Explain the development and proliferation of cancer with specific causes
Describe the influence of carcinogenesis in the cancer development
Identify the pathways and therapeutic targets of cancer
Outline the steps involved in metastasis and tumour cell invasion
Develop novel drugs and technologies for the treatment of cancer
Summarize the microenvironment of cancer cells and their attack on immune cells
TEXT BOOKS:
1. Weinberg, R.A. “The Biology of Cancer” Garland Science, 2007
2. McDonald, F etal., “ Molecular Biology of Cancer” IInd Edition. Taylor & Francis, 2004.
3. Pezzella, F., Tavassoli, M., & Kerr, D. J. (Eds.). (2019). Oxford textbook of cancer biology.
Oxford University Press.
4. Pelengaris, S., & Khan, M. (Eds.). (2013). The molecular biology of cancer: A bridge from
bench to bedside.
5. Hejmadi, M. (2014). Introduction to cancer biology. Bookboon.
REFERENCES:
1. King, Roger J.B. “Cancer Biology” Addison Wesley Longman, 1996.
2. Ruddon, Raymond W. “ Cancer Biology” IIIrd Edition . Oxford University Press, 1995
3. Margaret A. Knowles, Peter J Selby, An Introduction to Cellular and Molecular Biology of
Cancer, 4th Edition, Oxford Medical Publication, 1991.
4. https://oncouasd.files.wordpress.com/2014/09/cancer-principles-and-practice-of-
oncology-6e.pdf
5. https://archive.org/details/biologyofcancera00burc.
6. http://csbl.bmb.uga.edu/mirrors/JLU/DragonStar2017/download/introduction-to- cancer-
biology.pdf
126
