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Enteric Viruses Comparison

The document compares Poliovirus, Echovirus, and Coxsackie A & B, detailing their replication sites, pathogenesis, organs involved, clinical features, duration, transmission methods, and unique characteristics. Poliovirus primarily affects the CNS and can cause paralysis, while Echovirus is a common cause of aseptic meningitis. Coxsackie A and B have varied tissue tropism with associated diseases like herpangina and myocarditis, respectively.

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7 views1 page

Enteric Viruses Comparison

The document compares Poliovirus, Echovirus, and Coxsackie A & B, detailing their replication sites, pathogenesis, organs involved, clinical features, duration, transmission methods, and unique characteristics. Poliovirus primarily affects the CNS and can cause paralysis, while Echovirus is a common cause of aseptic meningitis. Coxsackie A and B have varied tissue tropism with associated diseases like herpangina and myocarditis, respectively.

Uploaded by

sizwe
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Feature Poliovirus Echovirus Coxsackie A & B

Site of Replication Oropharynx and small Oropharynx and small Oropharynx, small intestine;
intestine → lymphoid tissue intestinal mucosa spreads to multiple organs
(Peyer’s patches)

Pathogenesis Primary replication in gut → Primary replication in gut → Viremia → tissue tropism
viremia → may invade viremia → systemic flu-like varies: Coxsackie A
anterior horn cells causing illness or aseptic meningitis (skin/mucosa), Coxsackie B
paralysis (muscle, heart, pancreas)

Organs Involved Intestine, CNS (anterior horn Intestine, meninges Intestine, skin, oral mucosa,
cells) heart, pancreas, CNS

Clinical Features Asymptomatic or mild illness; Fever, rash, aseptic Coxsackie A: herpangina,
can cause paralytic meningitis; mild GI hand-foot-mouth disease.
poliomyelitis (flaccid symptoms Coxsackie B: myocarditis,
paralysis) pericarditis, pleurodynia

Duration Acute phase 3–7 days; Self-limiting, 3–7 days Self-limiting 3–7 days;
paralysis may persist myocarditis may persist

Transmission Fecal–oral; respiratory Fecal–oral; contaminated Fecal–oral; respiratory


droplets water droplets; fomites

Unique Features Only enterovirus causing Common cause of aseptic Coxsackie A: vesicular
paralysis; strong CNS meningitis outbreaks rashes. Coxsackie B:
tropism myocarditis (‘devil’s grip’
chest pain)

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