m3 - Rationale
m3 - Rationale
Step 3: Convert mg to g
Review of Conversion:
V D
X M
General rules:
• If a smaller numeral is placed _______ a larger numeral,
__________ its value (e.g., IV = 5 - 1 = 4).
• If a smaller numeral is placed after a larger or equal numeral,
_____ its value (e.g., VI = 5 + 1 = 6).
• The same numeral cannot be repeated more than _______ times in a row
(e.g., 40 is XL, not XXXX).
1
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
4. A child aged 5 years weighs 22 kg and has Answer: ________
a height of 95 cm is prescribed an adult Step 1: Young’s Rule formula:
antibiotic dose of 500 mg. Using Young’s
Rule, calculate the child’s dose in grams.
(Average Adult BSA = 1.73 m²)
A. 100 mg
Step 2: Substitute:
B. 142.9 mg
C. 166.7 mg
D. 0.143 g
Step 3: Convert mg to g:
Age
Young’s Rule Child’s dose = x Adult dose
Age + 12
Weight (lbs)
Clark’s Rule Child’s dose = x Adult dose
150
Age (months)
Fried’s Rule Infant’s dose = x Adult dose
150
Age (years) + 1
Cowling’s Rule Child’s dose = x Adult dose
24
Option 2
Step 4: Determine the ratio of each stock solution and the total number of parts.
Using Option 1:
3%
10%
15%
Total number of parts:
Step 5: Using dimensional analysis, calculate the amount of each stock solution to
be used.
3%
10%
15%
Rounded off, the correct values are in
2
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
6. A pharmacist needs to prepare 250 mL of Answer: ________
a 0.9% sodium chloride (NaCl) IV solution C₁ (stock concentration) =
from a 3% stock solution. How much of the C₂ (desired concentration) =
3% solution should be diluted with sterile V₂ (final volume) =
water to make the 0.9% solution? V₁ (volume of stock to use) =
A. 75 mL Formula:
B. 67.5 mL
C. 82.5 mL
D. 90 mL
Solve for V1 :
3
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
12. What is the specific gravity of a mixture of Answer: ________
1000 mL of syrup with a specific gravity of Step 1: Calculate the weight of each component.
1.300, 400 mL of glycerin with a specific
gravity of 1.250, and 1000 mL of an elixir
with a specific gravity of 0.950?
A. 1.1576
Step 2: Calculate the total weight and volume.
B. 1.1487
C. 1.1532
D. 1.1458
°C to °F
4
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
17. Hospitals may be classified in different Answer: ________
ways, including:
Classification
I. Type of service
II. Length of Stay • General • Rehabilitation and Chronic Disease
III. Ownership • Special • Psychiatric
IV. Bed Capacity
Classification
V. Profitability
• Short-term • Long-term
A. I, II, IV
Classification
B. I, III, IV
C. I, II, III, IV • ____________________ • ____________________
D. AOTA • Federal • Nonprofit
• State • For profit
Classification
A. Chairperson Purpose Advises the medical staff and administration on all matters related to
B. Secretary drug ___________, ______, and _________.
C. Procurement officer Key Function Maintain and revise the ___________________
D. External advisor
Members • _______________ - usually a • 1-2 nurses
physician (medical director) • Hospital Administrator
• ______________ - usually the • Consultants (optional)
chief pharmacist
• 3-5 physicians
19. A retired physician who no longer admits or 19. Answer: ________ 20. Answer: ________
treats patients, but is retained on the staff
in recognition of past contributions to the Type of Medical Staff Description
hospital. Closed
A. Consulting staff __________________________members recognized for past contributions;
B. Courtesy staff no active duties.
C. Honorary staff
Experts called for ________________________; not regularly involved in
D. Resident staff routine patient care.
20. A physician who has been granted limited Full-time ___________________________ under supervision.
hospital privileges to admit private patients
Fully credentialed physicians ________________ involved in patient care
occasionally, but is not regularly involved
and hospital activities.
in patient care, hospital meetings, or
administrative duties. Similar to attending but with ___________________ or
______________________.
A. Consulting staff
B. Courtesy staff Open not exclusive to the institution
C. Honorary staff Physicians with occasional _____________________ and minimal hospital
D. Resident staff involvement.
5
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
23. A public health department is evaluating Answer: ________
whether to implement a nationwide
smoking cessation program. Both the Method Description / Important Notes
costs of the program and the benefits (e.g., Estimates the ____________________ ___________ (direct, indirect, and
reduced healthcare spending, increased intangible); not a comparison tool.
worker productivity) are expressed in Compares costs of two or more interventions with ______________
monetary terms. ___________; choose the ____________.
Which pharmacoeconomic method is Measures outcomes in natural units (e.g., life-years gained, mmHg ↓);
most appropriate for this analysis? compares ________________________.
Outcomes measured in ___________________________________ or _______
A. Cost-effectiveness analysis _________________________________________.
B. Cost-minimization analysis
C. Cost-utility analysis Both costs and outcomes are converted into __________________; allows
comparison across sectors.
D. Cost-benefit analysis
24. Patients with confirmed CDI were Answer: ________
compared to hospitalized patients
without CDI). Researchers reviewed prior Study Design Description
medication records to determine PPI Participants are randomly assigned to groups receiving the
exposure and evaluated whether PPI use intervention or control
was more common among those who ____________________ for causality.
developed CDI. Cohort Study Follows a group over time to compare outcomes between
_________________________ individuals.
A. Randomized Controlled Trial (RCT)
B. Cohort Study Case-Control Study Compares patients with a condition (________) to those without
C. Case-Control Study (_________) to assess _________________.
D. Cross-Sectional Study Assesses both exposure and outcome at a _______________________
_________. Useful for ______________.
Case Report / Case Series Detailed ______________ of a ________ patient (case report) or a small
______ (case series). ___________ group.
Systematic Review __________________ results from multiple studies using a systematic
method.
Meta-Analysis _____________ quantitative data from ___________ studies to generate a
pooled ____________.
25. Primum non nocere: 25. Answer: ________ 26. Answer: ________
A. Non-maleficence Principle Description
B. Beneficence
C. Autonomy Respecting the individual’s right to _____________________ and
____________ ___________________.
D. Confidentiality
“Do good” Promoting the patient’s best interests and well-being.
26. A physician has instructed the healthcare
team not to reveal the full extent of a “_____________________,” meaning “Do no harm” — avoiding
unnecessary harm or risk to patients.
diagnosis to avoid upsetting the patient.
What ethical principle was violated? Ensuring ___________ in distribution of resources and equal treatment.
A. Autonomy Obligation to tell the _________; honesty in communication and
B. Beneficence documentation.
C. Veracity ____________________ and commitments; maintaining trust in
D. Non-maleficence professional relationships.
Respecting the __________ of patient information.
Being _________________ for one’s actions and decisions in professional
practice.
Upholding ethical standards, integrity, and respect for others.
6
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
28. Which of the following are classified as Answer: ________
a Category D (Specialized Outpatient)
Facility? Classification of Other Healthcare Facilities
I. Clinics A B C D
II. Drug Rehabilitation Centers
III. Dialysis Clinics
Basic _____________ _____________ care For ___________ Provides specific
IV. IVF Centers health service, may for chronic illness, or monitoring via _____________
A. I, II, III include short-term mental disorders, or _________ _____________ _____________ or
care. dependency. ________. treatments.
B. III, IV
C. II, III, IV Without beds: - Psychiatric centers - Labs (e.g. HIV, NBS) - ____________
D. I, II, III, IV ___________
- ___________ (medical, - ___________ - Radiologic centers
dental, OFW) (X-ray, CT, MRI) - Ambulatory surgical
- Nursing homes clinics
With beds: - Nuclear medicine
- Leprosaria facilities - ____________
- Infirmary
- Hospices - Chemo- therapy
- Birthing homes centers
- Rehab (physical
medicine) centers
- Radiation oncology
Interpretation:
7
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
32. A nurse mistakenly administers 200 mg 32. Answer: ________ 33. Answer: ________
of Phenytoin IV at a rapid push instead
of the prescribed 100 mg dose, due to a Medication Errors
misreading of the handwritten chart. The Type Description
patient does not experience any adverse
Has __________ for error, but ___________ ______________
reaction, but the error is identified during
post-dose charting and reported to the
hospital's medication safety committee. Error occurred, but ________________ the patient
What type of medication error is this?
Error __________ the patient, but ____________ occurred
A. Type C C. Type B
Reached the patient and _____________ ______________________________
B. Type E D. Type D
___, but no harm
33. An elderly patient received vincristine Caused ______________________ and required _________________
intrathecally instead of intravenously,
Caused _____________________ requiring initial or prolonged
resulting in irreversible paralysis.
__________________
A. Type E C. Type I
Caused ________________ patient harm
B. Type G D. Type H
Required intervention to ______________
Error resulted in ______________
34. This section of the PNF lists medicines for Answer: ________
priority diseases but may require special
diagnostic/ monitoring facilities, or be less Sections of the PNF
cost-effective, or have higher toxicity risks. Essential, cost-effective, for all levels of care; for _______________ of
These are used as alternatives. population
8
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
37. Determine the USP storage condition Answer: ________
classification of a shipment requiring 11±2
C. Storage Condition Meaning Storage Condition Meaning
(USP <659>)
A. Freezer
Freezer Controlled Room
B. Cold
Temperature
C. Cool
D. Controlled room temperature Cold Warm
42. This section states the primary reason for Answer: ________
the patient’s consultation.
Main reason for the visit
A. PMH
B. HPI Neural tube defects, hepatocellular carcinoma
C. ROS Detailed narrative of current symptoms
D. CC
Previous illnesses, surgeries, hospitalizations
Current and past medications
Health conditions in close relatives
Lifestyle, occupation, habits (e.g., smoking)
Systematic symptom check by body system
A. Metabolic alkalosis
B. Metabolic acidosis
C. Respiratory alkalosis
D. Respiratory acidosis
9
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
45. In drug interaction references, “drug Answer: ________
affected by the interaction is referred to as
the:
Precipitant ____________ the interaction
A. Receptor C. Substrate
B. Object D. Precipitant Object _____________ by the interaction
47. What adverse effect may result from the Answer: ________
intake of HMG-CoA reductase inhibitors?
Adverse Effect Commonly Associated Drug/Class
A. Rhabdomyolysis
B. Ototoxicity Rhabdomyolysis*
C. Gingival hyperplasia Ototoxicity
D. Hepatotoxicity
Gingival hyperplasia
Peripheral neuritis
A. Stage 1 1 3B
B. Stage 2 2 4
C. Stage 3A
D. Stage 4 3A 5
10
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
54. Iopamidol Answer: ________
A. Disinfectant Iodine-containing Radiocontrast Agents
B. Antiseptic
C. Radiocontrast agent CT scans, angiography, urography
D. Iodine supplement Renal imaging, GFR measurement, excretory urography
CT, intravenous urography, cerebral angiography
60. The following beta blockers can also block Answer: ________
alpha receptors, leading to an added
vasodilation effect: Beta-Blockers with MOA
vasodilatory effect
I. Labetalol III. Propranolol
II. Esmolol IV. Carvedilol
A. I, III, IV C. II and III
B. I and II D. I and IV
For 61-63: 61. Answer: ________ 62. Answer: ________ 63. Answer: ________
A 28-year-old female with a history of Class Drugs
moderate persistent asthma presents
for a routine follow-up. She reports Salbutamol (Albuterol), Terbutaline, Levalbuterol
occasional tremors and difficulty sleeping. Salmeterol, Formoterol, Indacaterol, Bambuterol
Her current medications include:
Beclomethasone, Budesonide, Fluticasone, Mometasone
Albuterol, Budesonide/Formoterol inhaler,
Montelukast, and Theophylline. Prednisone, Prednisolone, Methylprednisolone, Hydrocortisone,
Dexamethasone
61. Which of the following medications in this
Montelukast, Zafirlukast, Pranlukast
patient’s regimen is a long-acting beta-2
agonist (LABA)? Zileuton
A. Albuterol C. Formoterol Cromolyn sodium, Nedocromil sodium
B. Budesonide D. Montelukast
Theophylline, Aminophylline
62. The patient reports tremors and Ipratropium bromide
palpitations. Which drug is the most likely
cause of these symptoms? Tiotropium
A. Budesonide C. Albuterol
Common ADRs
B. Montelukast D. Theophylline
β2-Agonists (SABA & LABA)
63. Montelukast is classified as which of the
following? Inhaled Corticosteroids (ICS)
A. Inhaled corticosteroid Systemic Corticosteroids
B. Leukotriene receptor antagonist
Muscarinic Antagonists
C. Mast cell stabilizer (SAMA/LAMA)
D. Phosphodiesterase inhibitor
11
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
64. Which of the following is/are classified as Answer: ________
an aminoglycoside? Aminoglycosides
I. Rifampicin III. Erythromycin
II. Streptomycin IV. Gentamicin • •
• •
A. II, III C. II, III, IV
• •
B. I, II, III D. II, IV
“-mycin” - from _______________________
“-micin” - from _______________________
65. Indapamide belongs to which drug class? Answer: ________
A. Thiazide diuretics Thiazide Diuretics (TZD) Thiazide-like Diuretics
B. Sulfonylureas
C. SSRI Hydrochlorothiazide
D. Biguanide Chlorothiazide
Bendroflumethiazide
_________________________ lack the _____________________ ring but inhibit the same
_____________________ in the _______.
66. A 60-year-old man reports that he has Answer: ________
been smoking 15 sticks of cigarettes per
day for 25 years. How many pack-years has
he smoked?
A. 15 pack-years
B. 18.75 pack-years
C. 20.25 pack-years
D. 25 pack-years
67. Which of the following is correctly paired? Answer: ________
I. Heparin: aPTT III. Heparin: PT-INR Heparin (Intrinsic Pathway)
II. Warfarin: aPTT IV. Warfarin: PT-INR
Warfarin
A. I and IV C. II and IV (Extrinsic Pathway)
B. II and III D. I and III
Normal INR value in px taking warfarin:
68. Benzenesulfonylureas are therapeutically Answer: ________
employed as:
Drugs MOA Common ADRs
A. Diuretic
B. Antidiabetic 1st gen Stimulate __________ _______________,
secretion by blocking weight gain
C. Antihypertensive
K+ channels in
D. Antimicrobial __________________
2nd gen
12
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
72. In a drug interaction, what would best Answer: ________
describe the result if Drug A inhibits the In this scenario, Drug B is the _________ drug— it should be the one being
excretion of Drug B?* _________.
A. Drug A is rapidly cleared from the body
Excretion inhibited → _______________ promoted → _____________ serum levels of
B. Drug B becomes pharmacologically
Drug B (potentially ________)
inactive
C. Drug B levels increase, potentially
causing toxicity
D. Drug A neutralizes Drug B in the
bloodstream
73. What is the important patient counseling Answer: ________
point when dispensing corticosteroid- Inhaled corticosteroid use is associated with ___________________ (_____________).
containing inhalational preparations to __________________________ after use significantly reduces this risk.
asthmatic patients?
A. Take the medication only during asthma
attacks for quick relief.
B. Rinse the mouth with water after each
use.
C. Stop using the inhaler once symptoms
improve.
D. Shake the inhaler for at least 5 mins
before each use.
74. There is some evidence suggesting a Answer: ________
potential drug interaction may occur, but
more data are needed to confirm it. How is CLINICAL SIGNIFICANCE OF DRUG INTERACTIONS
this interaction classified? Established ____________ and __________________; supported by well-controlled
studies
A. Probable
B. Suspected Probable __________________; strong clinical suspicion
C. Possible Suspected ______________ occur; needs more evidence
D. Unlikely
Possible ____________ occur; data are limited or conflicting
Unlikely ______________ or rare
75. Which of the following are examples of 75. Answer: ________ 76. Answer: ________
potentiation reactions?
Type of Interaction Examples
I. Augmentin®
II. Sinemet® • Alcohol + ______ → ↑ CNS depression
III. BZD + Alcohol • Warfarin + aspirin → ↑ __________ risk
IV. Epinephrine + Histamine • ACE inhibitor + diuretic → ↑ hypotension
• Antihistamine + sedative → ↑ ______________
A. I and II • Sulfamethoxazole + _____________ → ↑ antibacterial activity
B. I, II, III (bactericidal)
C. III and IV • Clopidogrel + aspirin → ↑ antiplatelet effect
D. NOTA • Nitrate (or other potent vasodilators) + sildenafil → risk of severe
__________________
76. 1+1=3
A. I and II K– A–
B. I, III, and IV F– P–
C. III and IV
A– G–
D. AOTA
C– P–
E– S–
S– T–
C–
O–
M–
Note:
____________________ is the only macrolide that has no enzyme inhibition effects.
13
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
78. Aspirin was administered with magnesium 78. Answer: ________ 79. Answer: ________
hydroxide. What will be the resulting
interaction? Drug Environment Form
BNs:
• Advil -
• Cataflam/Voltaren -
• Ponstan/Dolfenal -
• Flanax -
82. Which of the following is not a prescription Answer: ________
(Rx) medication?*
Diphenhydramine ________ antihistamine
A. Diphenhydramine
B. Sertraline Sertraline ________ antidepressant
C. Amoxicillin Amoxicillin ________ antibiotic
D. Atorvastatin
Atorvastatin ________ statin for cholesterol
14
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
86. Which of the following adverse drug 86. Answer: ________ 87. Answer: ________ 88. Answer: ________
reactions is classified as Type C?
ADR Type
A. Anaphylaxis from penicillin
B. Teratogenicity from isotretinoin ________________ – • ____________________ with insulin
__________________ and • ______________ with warfarin
C. EPS with prolonged antipsychotic use
______________ from known
D. Rebound hypertension after clonidine pharmacology
• Bradycardia with beta-blockers
withdrawal
ADR Type
87. Which of the following are correctly
______________ – Not dose- • Anaphylaxis from penicillin
paired? dependent, unpredictable, • Stevens-Johnson Syndrome (SJS) from _________________
I. Stevens-Johnson Syndrome from often immunologic or
• SLE from HIPS (_______________, _______________, _______________,
genetic
sulfonamides – Type B _______________)
II. Bleeding from warfarin – Type C ADR Type
III. Carcinogenicity from alkylating agents
– Type D ___________ – Related to • _______________________ (Adrenal suppression from chronic
long-term therapy steroids)
IV. Oral contraceptive failure due to
• _______ with prolonged antipsychotic use
rifampin – Type F
• Alcohol addiction/ dependence
A. I and II only C. I, III, and IV only
ADR Type
B. II, III, and IV only D. All of the above
_________ – Effects appear
88. An unknowingly pregnant woman took after prolonged use (even
diethylstilbestrol (DES) for prevention of after discontinuation)
miscarriage. The baby was delivered safely, ADR Type
but after 20 years, she developed clear
cell adenocarcinoma of the vagina, a rare __________________ • _______________________ (adrenal insufficiency after CS withdrawal)
(withdrawal) – Reactions • _______________________ after stopping clonidine or beta-blockers
malignancy. What type of adverse drug due to __________
reaction is this? • Insomnia, anxiety after discontinuing SSRIs
__________________
A. Type D C. Type B ADR Type
B. Type C D. Type A
________ of therapy – • Therapeutic failure of OCPs due to _________ ______________
Usually due to drug–drug • Antibiotic resistance
interactions, resistance, or
• Subtherapeutic dosing
inadequate dosing
• Lack of ______________ _________________
90. Ebstein’s anomaly is a teratogenic effect 90. Answer: ________ 91. Answer: ________
caused by taking ___________ during the
first trimester of pregnancy. Drug / Drug Class Teratogenic Effects
15
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
93. Which of the following conditions Answer: ________
will result in decreased absorption or Refer to Item 78 rationale.
reabsorption of the drug?
Duodenum (Small Intestine) - ______ environment
I. Acidic drug in the duodenum
II. Acidic drug in the stomach Stomach - ________ environment
III. Basic drug in the stomach
IV. Alkaline drug in acidic urine
Same pH →
A. I and II C. II and III
B. I, III, and IV D. I, II, III, and IV Opposite pH →
94. What type of Error is shown in the 94. Answer: ________ 95. Answer: ________ 96. Answer: ________
prescription?
Error Type Examples Fill File and report
Patient Name: Juan dela Cruz
Age/Gender: 35/Male - ____ written before ____
Date: June 27, 2025 Erroneous - GN in _______________
- ____ not enclosed in parenthesis
Rx
Biogesic (Paracetamol) 500 mg - Only the ____ is written
Take 1 tablet every 6 hours as needed for Violative - GN is _________________
headache
- "_____________________"
16
MODULE 3
Practice of Pharmacy FINAL COACHING NOVEMBER 2025
Question Rationale
100. Which of the following is the most Answer: ________
common adverse effect associated with Isosorbide dinitrate (ISDN), a ________ vasodilator, causes _________________,
ISDN therapy? leading to increased intracranial blood flow. This commonly results in
A. Bradycardia C. Hypokalemia ________________________, especially at the start of therapy.
B. Headache D. Dry cough
Recall ________________________________.
17