Fluids and Electrolytes in Paediatrics – Questions
& Explanations
Q: What are the major differences in body water composition between neonates, infants, and older
children?
A: Neonates: ~75–80% body water, Infants: ~70%, Older children: ~60%. Higher ECF proportion in
neonates → prone to rapid fluid shifts.
Q: Why are infants more prone to dehydration than adults?
A: Higher surface area-to-volume ratio, higher metabolic rate, immature kidneys, greater insensible
water losses.
Q: How do you calculate maintenance fluid requirements in children (Holliday–Segar method)?
A: 100 ml/kg for first 10 kg, 50 ml/kg for next 10 kg, 20 ml/kg for each kg above 20 kg.
Q: How do you classify dehydration clinically in children?
A: Mild (3–5% weight loss), Moderate (6–9%), Severe (≥10%). Clinical signs: sunken eyes, dry
mucosa, tachycardia, delayed cap refill, shock.
Q: A 10-kg child presents with 10% dehydration. Calculate the fluid deficit.
A: 10% of 10 kg = 1 kg water loss ≈ 1000 ml deficit. Replace over 24–48 hours + maintenance
fluids.
Q: What are the appropriate fluids for resuscitation vs maintenance in paediatrics?
A: Resuscitation: isotonic crystalloids (0.9% saline, Ringer’s lactate). Maintenance: isotonic fluids
(0.9% saline or Ringer’s + 5% dextrose + KCl if not oliguric).
Q: Why is 0.18% saline (hypotonic solution) no longer recommended for maintenance fluids?
A: Risk of hospital-acquired hyponatremia → seizures, cerebral edema.
Q: What are the electrolyte abnormalities commonly seen in pyloric stenosis?
A: Hypochloremic, hypokalemic metabolic alkalosis due to persistent vomiting.
Q: Causes of hyponatremia in children?
A: Diarrhea, vomiting, SIADH (meningitis, pneumonia, post-op), excessive hypotonic fluids.
Q: Causes of hyperkalemia in children?
A: Renal failure, tissue breakdown (hemolysis, rhabdomyolysis, burns), acidosis,
potassium-sparing diuretics.
Q: How does fluid management differ in neonates compared to older children?
A: Neonates require more careful titration: higher TBW, immature renal handling, avoid fluid
overload. Start ~60–80 ml/kg/day and increase gradually.
Q: What fluid and electrolyte problems are common in intestinal obstruction?
A: Dehydration, hypochloremic alkalosis, hypokalemia due to vomiting and sequestration of fluids in
bowel loops.
Q: How would you manage electrolyte balance in a child with a high-output stoma?
A: Replace stoma losses ml-for-ml with isotonic fluids containing Na+, K+, and bicarbonate; monitor
weight and electrolytes closely.
Q: What is the risk of over-resuscitation with crystalloids in neonates?
A: Pulmonary edema, patent ductus arteriosus exacerbation, necrotizing enterocolitis, intracranial
hemorrhage.