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Cholinergic Drugs Classification Final

Cholinergic drugs are classified into direct-acting agonists, which mimic acetylcholine by activating receptors, and indirect-acting drugs, which inhibit acetylcholinesterase to increase acetylcholine availability. Direct-acting drugs include choline esters like acetylcholine and cholinomimetic alkaloids like pilocarpine, while indirect-acting drugs are categorized into reversible and irreversible types, with examples such as physostigmine and echothiophate respectively. The document also provides references for further reading on cholinergic agonists and antagonists.

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Jude Daniel Aquino
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320 views3 pages

Cholinergic Drugs Classification Final

Cholinergic drugs are classified into direct-acting agonists, which mimic acetylcholine by activating receptors, and indirect-acting drugs, which inhibit acetylcholinesterase to increase acetylcholine availability. Direct-acting drugs include choline esters like acetylcholine and cholinomimetic alkaloids like pilocarpine, while indirect-acting drugs are categorized into reversible and irreversible types, with examples such as physostigmine and echothiophate respectively. The document also provides references for further reading on cholinergic agonists and antagonists.

Uploaded by

Jude Daniel Aquino
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Cholinergic Drugs Classification

A. DIRECT-ACTING (RECEPTOR AGONIST)


- Mimics the effects of acetylcholine by binding directly and activating muscarinic or nicotinic receptors.

Types of Direct Acting


a. Choline Esters
Examples:
 Acetylcholine
 Bethanechol
 Carbachol
 Methacholine

b. Cholinomimetic Alkaloids
Examples:
 Pilocarpine
 Muscarine
 Arecoline

B. INDIRECT-ACTING
- Do not act on receptors
- Inhibit the enzyme acetylcholinesterase  more Ach available

Types of Indirect Acting


a. Reversible – binds to cholinesterase for a period of minutes to hours
Examples:
Lipid Soluble Water Soluble
 Physostigmine  Neostigmine
 Donepezil  Edrophonium
 Tacrine  Pyridostigmine

b. Irreversible – binds to cholinesterase and form a permanent covalent bond


Examples:
 Echothiophate

 Parathion
 Malathion

 Diazinon

 Sarin

 Soman
References

Cholinergic Agonists and Antagonists. (2017, April 8). Basicmedical Key. Retrieved November 8, 2022, from

[Link]

Cholinergic and Anticholinergic Drugs (Video). (2022, May 10). Mometrix. Retrieved November 8, 2022, from

[Link]

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