MATERIAL SAFETY DATA SHEET
Name of The Product INDAPAMIDE
Section 1- Chemical Product and Company Identification
Product Chemical Name : 4-Chloro-N-(2-methylindolin-1-yl)-3-Sulfamoylbenzamide(or) 4-Chloro-N-
[(2RS)-2-methyl-2-3- dihydro- 1H-indol-1-yl]-3-Sulfamoylbenzamide (EP)
Synonym : Not applicable
Company Name Sionc Pharmaceuticals Pvt Ltd. Unit-II
Plot No- 25 & 25A Road No: 01, TSCA Inventory: Not available
JN. Pharma City, Thanam (Village), In Case of CALL
Emergency: +91-891-3500702/724
Parawada (Mandal)
Visakhapatnam-531 021, Andhra Pradesh, INDIA.
Phone No.: +91-8924-236 966
Trade name : 4-Chloro-N-(2-methylindolin-1-yl)-3-Sulfamoylbenzamide(or) 4-Chloro-N-
[(2RS)-2-methyl-2-3- dihydro- 1H-indol-1-yl]-3-Sulfamoylbenzamide (EP)
Material Use : For synthesis.
Section 2: Composition and Information on Ingredients
Chemical Name : 4-Chloro-N-(2-methylindolin-1-yl)-3-Sulfamoylbenzamide(or) 4-Chloro-N-
[(2RS)-2-methyl-2-3- dihydro- 1H-indol-1-yl]-3-Sulfamoylbenzamide (EP)
CAS No. : 26807-65-8
Section 3- Hazards Identification
Physical State and Appearance White or Almost white Powder
Emergency Overview The toxicological properties of this material have not been fully investigated .
This is expected to be a low hazard for usual industrial handling.
Routes of Entry skin, eye, inhalation, ingestion
Potential Acute Health Effects Eye Wear suitable goggles or face protector
Skin Causes skin irritation, Wear protective clothing
Inhalation In case of suffocation wear respiratory protective equipment
Potential chronic health CARCINOGENIC EFFECTS: Possible hyper sensitization.
Effects MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
Medical Condition Persons with pre-existing eye, respiratory, neurological, asthmatic or kidney conditions.
Aggravated by overexposure might be more sensitive.
Over exposure/signs/ Not available.
Symptoms
See Toxicological Information (Section 11)
Section 4: First Aid Measures
Eye Contact IMMEDIATELY flush eyes with running water for at least 15 minutes, keeping
eyelids open. COLD water may be used. Seek medical attention
Skin Contact Flush skin with plenty of soap and water for at least 15 minutes while removing
contaminated and shoes. Get medical aid if irritation develops and persists.
Hazardous Skin Contact May cause sensitization by skin contact.
Inhalation If inhaled, remove to fresh air, if breathing becomes difficult, call a physician
Hazardous Inhalation Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such
as a collar, tie, belt or Waist and. IF breathing is difficult, administer oxygen. If
the victim is not breathing, perform Artificial respiration. Obtain immediate
medical attention
Ingestion Induce vomiting. Examine the lips and mouth to ascertain whether the tissues are
damaged, a possible indication that the toxic material was ingested: the absence
of such signs, however, is not conclusive. Loosen tight clothing such as a collar,
tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Have conscious person drink several glasses of water or milk.
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MATERIAL SAFETY DATA SHEET
Name of The Product INDAPAMIDE
Seek immediate medical attention.
Section 5: Fire Fighting measures
Flammability of the product Non-Flammable.
Auto-ignition Temperature Not available.
Flash Points CLOSED CUP: Not available. OPEN CUP: Not available.
Flammable limits LOWER: Not available. UPPER: Not available.
Products of Combustion These products are carbon oxides, Nitrogen oxides (CO, & CO2) and Hydrogen chloride
gas
Fire Hazards in presence of Emits toxic fumes under fire conditions
Various Substances.
Fire Hazards in presence of Risk of explosion of the product in presence of Mechanical impact: NONE.
Various Substances Risk of explosion of the product in presence of static discharge: NONE.
Special Remarks on Fire Hazards: No additional information.
Special Remarks on Explosion Hazards: No additional information.
Section 6: Accidental Release Measures
General Information Use proper personal protective equipment as indicated in Section 8
Spills/Leaks Vacuum or sweep up material and place into a suitable disposal container.
Section 7: Handling and Storage
Handling Avoid exposure-obtain instructions before use. Avoid formation of dust and
aerosols. Provide appropriate exhaust ventilation at places where dust is
formed. Normal measures for preventive fire protection.
Storage Preserve in tight, light-resistance container, Store at below 25°C,
excursions permitted between 15° C and 30°C.
Section 8: Exposure Controls/Personal Protection
Engineering Controls Provide exhaust ventilation or other engineering controls to keep the airborne
concentrations of vapors below their respective threshold limit value. Ensure that
eyewash station and safety showers are proximal to the workstation location.
Personal Protection
Eye safety glasses.
Body Lab coat
Respiratory Vapor and dust respirator. Be sure to use a MSHA/NIOSH approved respirator or
equivalent
Wear appropriate respirator when ventilation is inadequate.
Hands Rubber Gloves.
Feet Rubber boots.
Personal Protection in case of a large spill Splash goggles. Full suit. Boots. Gloves. Suggested protective
clothing might not be sufficient consult a specialist BEFORE handling this product.
Product name: 4-Chloro-N-(2-methylindolin-1-yl)-3-Sulfamoylbenzamide(or) 4-Chloro-N-[(2RS)-2-methyl-2-
3-dihydro-1H-indol-1-yl]-3-Sulfamoylbenzamide (EP)
Exposure Limits None listed from ACGIH, NIOSH & OSHA-Final PELs/Vacated PELs
Section 9: Physical and Chemical Properties
Molecular Formula : C16H16CIN3O3S
Molecular Weight : 365.83 g/mole
Physical State and Appearance : White or Almost white Powder.
Solubility : Soluble in Ethanol (96%), Practically insoluble in water Soluble in Methanol and
Acetonitrile
Section 10: Stability and Reactivity Data
Chemical Stability Stable under above mentioned storage conditions
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MATERIAL SAFETY DATA SHEET
Name of The Product INDAPAMIDE
Conditions to Avoid Strong oxidizing agents.
Hazardous decomposition products materials Hazardous decomposition products formed under fire
conditions. –Carbon dioxide.
Hazardous decomposition products Carbon monoxide, Carbon dioxide, Nitrogen oxides
Hazardous Polymerization Has Not been reported
Section 11: Toxicological Information
Information on toxicological effects
Acute toxicity: LD50 Oral- rat-3000 mg/kg`
irritation and corrosion: Skin irritation
Sensitization: Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals. The
preceding data, was determined using quantitative structure Activity Relationship (QSAR) Modeling
Chronic exposure: IARC No component of this product present at levels greater than or equal to 0.1% is identified
as possible or confirmed human carcinogen by IARC.
Genotoxicity : No data available
Section 12: Ecological Information
Do not allow product to enter drinking water supplies, waste water or soil.
Section 13: Disposal Considerations
Product Observe all federal, state, and local environmental regulations. Contact a licensed professional waste
disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a
chemical incinerator equipped with an after burner and scrubber.
Contaminated Packaging Dispose of as unused product.
Section 14: Transport Information
ADR/RID Classification: Non-hazardous for road transport.
IMO/IMDG Classification: Non hazardous for sea transport.
ICAO/IATA Classification: Non hazardous for air transport.
Section 15: Other Regulatory Information
TSCA No information available
SARA No information available
Section 16: Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind, It shall be used
only as guide. we assume no liabilities from the use of this product or information contained herein.
Notice to Reader:
The information above is believed to be accurate and represents the best information currently available to us.
However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such
information, and we assume no liability resulting from its use. Users should make their own investigations to
determine the suitability of the information for their particular purposes.in no way shall Sionc pharmaceuticals
be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental,
consequential or exemplary damages, howsoever arising, even if Sionc pharmaceuticals has been advised of the
possibility of such damages.
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