Medicine_Pathology- SECOND MBBS (2023)_Paper-l_ Sectton B_|

Pathology
Time:3 Hrs C 1 2 0 2 A

Max, Mrks : 80.00

Version:
Question Booklet Sr, No, :

Section B

[Link] Answer Questions (1x7=7.00)

a.

Describe the roles &responsibilities towards patients, fellow team

workers in a laboratory set up. members, seniors and other health care

[Link] Answer Questions (Solve any 3 out of 4)

(3x7-21.00)
a.

What is Cytology? Mention the various types of cytology and their clinical
applications.
b.

Define Gangrene. Enumerate the differences between Dry and Wet Gangrene.
C

Define Inflammation. Describe the Cellular Events in Acute Inflammation.

d

Describe pathogenesis, clirical features and laboratory investigations in Thalassemia Major.

[Link] Answer Question

(1x12=12.00)
a

Describe Amyloidosis under following headings.

a) Definition (1)
b) Classification (3)
c) Morphology of Kidney and Spleen in Amyloidosis (6)
d) Special stains (2)

[Link] Answer Questions (Sove any 4 out of 5) (4x7-28.00)

a

Enumerate transfusion reactions. Describe investigations in a case of mismatched blood transfusion,

b

Enumerate the pathological lesions and clinical manifestations of HIVIAIDS

 Define Neoplasia, Enumerate the differences betwoon Benign and Malignant Tumors.

Descnbe Laooratory investigations in Chronic Myelold Leukaemia with blood picture.

Enumerate causes, pathogenesis,clinical features and laboratory investigations in Disseminated Intravascular

Coagulation,

[Link] Answer Question (1x12=12.00)

A28-year-old female presented with menorrhagia since 2 months. She also complained of fatigue and shortness
of breath on exertion, On examination, Pallor +++, Koilonychia noted, Pulse: 92/min, BP: 110/70. mm of
[Link]- Hb 7.8gm%, MCV- 58 fl, MCH- 22 pg.
a) What is the most probable diagnosis? (1)
b) What are the causes for this condition? (3)

c) Describe Peripheral Blood Smear &Bone Marrow findings in this case. (6)
d) Enumerate the additional tests which can be helpful indiagnosis. (2)
 Mediclne Pathology-I| SECOND MBRS (2023)_IPaper-11_Sectlon B_1

Pathology-1l C1202B
Timc:3 Hrs
Max, Marks :80.00
VaNin:
Qucstion Booklet Sr. No, :

Section B

(1x7=7.00)
[Link] Answer Qucstions
3.

undergo
A55-year-old male patient who has been diagnosed with early-stage laryngeal carcinoma is advised to
patient
total laryngectomy for curative treatment. After being explained the risks, benefits, and alternatives, the
refuses surgery, stating he would prefer to try alternative therapy and preserve his voice.

(a) Define informed consent and informed refusal. (2 marks)

(b) Explain the principle of patient autonomy in this context (2 marks)
c)As a medical student, how should you respond when a competent patient refuses a recommended treatment?
(3 marks)

[Link] Answer Questions (Solve any 3 out of 4) (3x7-21.00)

Write briefly about the indications and contraindications of lumbar puncture. What are the findings seen in
patients with tubercular meningitis? (4+3 marks)
b

Classify aneurysms. Write in brief about the complications of aortic aneurysms. (4+3 marks)
C.

Tabulate the differences between ulcerative colitis and Crohn's disease.

d

Classify tumours of the bone. Describe the radiological, gross, and microscopic features of osteosarcoma. (3+4
marks)

[Link] Answer Question (1x12=12.00)

a.

(a) Enumerate the major risk factors associated with breast cancer. (2 marks)
(b) Describe the classification of breast carcinoma, incuding in situ and invasive types. (4
marks)
(c) Briefly outline the important gross and microscopic features of invasive ductal carcinoma. (4 marks)
(d) List the commoniy used prognostic and predictive markers in breast cancer. (2 marks)

[Link] Answer Questions (Solve any 4 out of 5) (4x7-28.00)

Classify cirrhosis. Describe microscopic features and complications of alcoholic liver cirhosis. (3+4
marks)
b

Enumerate investigations that you would like to order in a 65-year-old diabetic woman who
complaints of fever, burning in micturation and foul smelling urine. presents Win
Phar

ogy-!
Irs Describe the morphological findings in carcinonma of prostate.
ks:

Bo
Describe pathogenesis, gross and microscoplc features of colloid goitre.

Differentiate between nephrotic and nephritic syndrome. Describe briefly the pathogenesis and microscopic
features of post-streptococcal glomerulonephritis. (3+4 marks)
[Link] Answer Question (1x12-12.00)

3,

A 58-year-old man with ahistory of hypertension and smokingpresents to the emergency department with
sudden onset of severe, central chest pain radiatingto the left arm. The pain startedone hour ago while climbing
stairs. He is sweating profusely and is anxious. ECG shows ST-segment elevation in the anterior chest leads.
Blood samples are sent for analysis.
(a)Based on the clinical presentation, what is the most probable diagnosis? (2 marks)
(b) What are the keypathological events that could have led to this condition? (4 marks)
(c) Which biochemical tests would help confirm the diagnosis? Describe their time course (4 marks)
(d) Mention two possible complications if this condition is not treated promptly. (2 marks)
 C1203A
BECOND [Link] (CBME 2023) EXAMINATIONS
MICROAIOLOOY .1
SECTION
Total Duration : 3 Hrs.
Use black ball
Total Marks : 80
Instrvction.: 1) point pen only
Do not write Anything on the
blank
itten anythng. such type of act willportion of the
be consideredquestion paper. If
resort to untair means as an attempf to
All questions are
The number to the compulsory.
right indicates
5) Draw diagrams wherever full marks.
e Distribution of necessary.
syllabus in Question
syllabus within the stipulated Paper is only meant to cover
frame.
Ouestions trom the syllabus can This format is a mere guideline. entire
cannot claim that the be asked in any
Question is out of syllabus. as paper. Students
distribution has been given only for the this
7) Usea common answer book for sake of placement. format and
all sections.

2. Short Answer Question (Compulsory):

(1x7=7)
a) A 25-year-old woman who is 12 weeks pregnant lost
her husband in
The girl's parents want the doctor to convince the girl to abort the childanso accident.
that she
can remarry easily. The girl is adamant about having the baby saying that her
husband would have wanted it that way. The doctor is threatened by the woman's
family andoffered a bribe to conduct an MTP.
i) Define patient autonomy. (1)
ii) Contrast autonomy and paternalism. (3)
ii) What are the responsibilities of patients and doctors in shared decision
making? (3)
[Link] Answer Question : (Any 3out of 4) (3x7=21)
a) Write in brief about mechanisms of transmission of genetic material. Write 4
differences between mutational and transferable drug resistance.
b) What is window period for HIV? Describe NACO strategies with its use.
c) Enumerate differences between active and passive immunity with suitable
examples.
d) Enumerate the organisms causing hepatitis. Discuss the laboratory diagnosis
of
Hepatitis B virus infection.
(1x12=12)
4. Structured Long Answer Question (Compulsory):
(2)
a) Define Sterilization and Disinfection.
Enumerate different chemical disinfectant. (3)
Medical Devices. (3)
Write about Spaulding classification of surgery, how should the laparoscope
After conducting alaparoscopic abdominal transmission of infection? (4)
prevent
be reprocessed before its next use to

PTO
 C1203B

Iedicin

5. Short Answer Questions (Any 4Out of 5) : (4x7=28)

icrobic

me:3 a) A 28-years-old patient presented to oPD with step ladder fever, anorexia,
ax. M abdominal pain, nausea and vomiting since 4-5 days. Clinical examination
revealed coated tongue and palpable spleen. Which microbiological investigations
uCstic
will you recommend in this case with 4-5 days history? Describe in detail about the
most recommended investigation.
b) Discuss life cycle and lab diagnosis of Entamoeba histolytica.
c) Discuss the laboratory diagnosis of Infective Endocarditis.
d) Define Hypersensitivity. Write a note on Type IV Hypersensitivity.
e) Describe the pathogenesis and laboratorydiagnosis of acid peptic disease caused
hy Helicobacter pylori.
6. Structured Long Answer Question (Compulsory) :
(1x12=12)
a) A 45-year-old man workingas adomestic helper presents with
and a loss of weight and appetite over the last two months. He intermittent fever
has pallor and mild
hepatosplenomegaly. On investigation, he is anemic with raised ESR. Bone
marroW smear showed for LD bodies.
i) What is the diagnosis? (1)
ii) Drawa well labeled diagram of LD body. (2)
i) Describe the pathogenecity of the desease. (4)
iv) Add a note on its laboratory diagnosis. (5)
 CI203B

\'rerts

(Sotve Any 4 out

of 5) (487-20)
Ostions
[Link] Anwrr

pathogenesis
of SARS COV-2 infections.(3)
Descnbe the
diagnosis(4)
laboratory
the
Write in brief about

shephard develops
a blackish painless ,vesicular, non-itchy lesion which gradually turned
A40 vear old with an eschar. Multiple satellite lesions were seen around the lesion.
edematous and was covered
diagnosis?(1)
most probable
What could be the
micro-organism/s?(1)

What are the causative

diagnosis of the condition/5)
Write inbrief about the laboratory

C.

infections(2).
Enumerate the viruses
associated with sexually transmitted

viruses(5)
Write in brief about Herpes simplex-2

Describe the pathogenesis and laboratory diagnosis of

Gas gangrene.
C.

Mycobacteria.(2)
Describe Runyons classification of Atypical
Give two examples of each.(2)

Write about Buruli ulcer(3)

(1x12=12.00
[Link] Answer Questions
a.

nonthrobbing headache; fever of 38-40° C; sore

A5 year old unvaccinated boy from a rural area generalized,
pain and paraesthesia in the lower
throat; anorexia; nausea; vomiting; and muscle aches. He gradually developed muscle.
limbs and found unable to walk on [Link] examination also revealed hypotonia of
What is the most probable diagnosis7(2)
Describe the pathogenicity (3),
Laboratory diagnosis (3)
 Immunoprophylaxis of this clinical condition.(4)
(437-28.00)
[Link] Answer Questions(Solve any 4 Out of 5)3

Hospital Infecion Contol

healthcare associated infection (HAI). Mention the types of HAI Writea note on
Define
Committee (HICC).

Write a note on Toxic Shock Syndrome.

Write about Prion diseases and their laboratory diagnosis in brief.

laboratory diagnosis.
Write in brief about of allergic bronchopulmonary aspergillosis and its

e.

infections.(2)
Write about the aeitogical agents of urinary tract
of urinary tract infections.(5)
What are the screening methods for presumptive diagnosis
ye
es
(1x12=12.0
[Link] Answer Questions

a.

Enumerate Aeitological agents of upper respiratory tract infections.(2)

Influenza viruses.(6)
Write in brief about pathogenesis, laboratory diagnosis and treatment of

Add a note on Antigenic shift and Antigenic drift .(4)

 Medicint "hatme(nlogy sCOND MHNS ()0)) Taptt Setlon
Ihananlgv
Time 1Ars C1201A
Mat, Mai NO 00
l'sion
uenn Rukl St No

Sectlon t

[Link] Answer Questions (17-7.00)

Explain in brief all principles of Bioethics. A35 years old male patient is undergoing appendicectomy by
abdominal cavity. Operating surgeon found Mesenteric Lymphadenopathy intraoperatively and took biopsy opening
without patientlegal guardian's consent. Please opine on the principle of bioethics; surgeon
principle; he obeyed. What could surgeon must have done considering Bioethics Principles? violated and the

[Link] Answer Questions (Solve any 3 out of 4) (3x7=21.00)

Classify drugs used in management of Bronchial Asthma. Write a note on management of Status
Asthmaticus.
b.

Classify various antiarrhythmic agents. Write a note on mechanism of action, adverse

Amiodarone. effects and uses of
C

Classity various anti-anginal drugs. Explain indetail management of acute attack of Myocardial Infarction.
d.

Explain the drug, Digoxin with respect to its mechanism of action (with welllabelled diagram) and
extracardiac/cardiac adverse effects with their management.

[Link] Answer Question (1x12=12.0

a.

42 years old male patient working in marketing field since last ten years, complains of headache and mild
giddiness every evening since last fifteen days. His bloodpressure was found to be between150/90 to 170/100
mmHgduring work hours. He is diagnosed with Moderate Hypertension after thorough investigations.
1)What will be your first line of management for treatment of Moderate Hypertension.
2) Clàssify Antihypertensive agents in detal.
3) Explain advantages of Angiotensin Receptor Blockers (ARB) over Angiotensin Converting Enzyme Inhibitors
(ACEI).

(4x7=28.00)
[Link] Answer Questions (Solve any 4 out of 5)

Glassity adrenergic agents as per their various pharmacologicalactions. Write

anote on dose dependent action
of Dopamine.
b
 ma Mall Tifo of a druo Explalntho coool of Erst Oder and Zoto Order Kinotics with suitable
6anple

Explnin thelr cardinc

and non-cardiac uses in
Claeslfy varioua non salective and oardlosolecllvn leta blookers.
detel

Iron therapy. Write

Fmnrntn varous parenteal lton prepArallonn, EXplalnvartoun Jpdloalons of Parenteral
phamaellherapy of Aoute lon polaonlng.

Clanelly "arenteral anttooaqulanta, ConpAreand contrant Untractlonated Heparln (UFH) and Low Molecular
Welyht Meparin ( MVW),
(1x12-12.00)
Quen ny Ane )uetlon

Mi 'MN, a 3 yearold man, oomes to the emergenoy unlt with complalnte of ewellng of lips and tongue, a
yenaralized Mehy rash, brealhlesanesa, and glddneas. On enqury, he le found to have taken ono of the antiblotic
fot pharynglla On examlnatlon, PMN has the followlng vltale: pulae rate was 140 bpm, resplratory rate was 48
pn, ant AP of 00/40 nm of Hg. He la droway and pale, but reaponda to commands. His lung examination
elewe wlheezinu

) Mentity hia Adverae Drug Reactlon, Explaln Indetall, Ite management.

)Detne the ten, "Atverae dnigu Reaotlon", Explaln ite two types with sultable exemples.
1Whatin hamacoNulanoe Wite a note onPhamacoviglance Programme of India (PvPl).
 Medicine harmacnlngy-11 SCOND MRUN (023) "apt Setnn I
C1201B
Tharnacology-11
Time: 31As
May, Mtks NO, 00
Versin
Questun Bnklet St. N
Sectlon R

(4x7-28.00)
[Link] Answer Questions (Solve any 4 out of 5)

depression. Compare tricyclic antidepressants (TCA)

WItn Selectve
List groups of drugs used to treat mental
Serotonin Reuptake Inhibitors (SSRI).

short term and long term adverse effects of oral

List life saving uses of glucocorticoids. Discuss the
minimized?
glucocorticoids and describe how they can be

examples. List desirable characteristics of a good chelating

Explain the term chelating agents, giving suitable
agent. Write a short note on Desferasirox.
d
contraindications
action, adverse effects, indications and
Classify opioid analgesics. Describe the mechanismof
for opioid analgesics

e.

mentioning the preferred agent.

Describe mechanism of action and therapeutic uses of various benzodiazepines,
barbiturates.
List 3 clinically important differences between benzodiazepines and

[Link] Answer Questions (1x12=12.00)

A30 year woman was admitted in the hospital with history of fever with chils and rigors, nausea and malaise for
last 5days. Her blood tests showed hemoglobin of 10gm% and presence of plasmodium vivax trophozoites in
the peripheral smear.
a) Prescríbe the complete drug therapy for this patient. (4 marks)
b) Represent the life cycle of plasmodium vivax diagrammatically and classify the antimalarial drugs on the basis
of their action on various stages of the malarial parasite? (4 marks)
c) Describe the adverse effects and various non-malarial uses of chloroquine (4 marks)

[Link] Answer Questions(Solve any 4 Out of 5) : (4x7-28.00)

Describe the mechanism of action of lignocaine and explain why its local anesthetic effect is reduced in presence
Of pus and inflammation? What are the adverse effects and non-anesthetic uses of lignocalne?

b
Compare and contrast the pharmacology of oxytocin and ergometrine.

immunodeficiency virus, giving examipleS al

LIst Vanious groups of drugs used in the treatment of human
principles of treatment of HIV infection merttoning the
descnbe the target sites of antiretroviral drug. Outline the
parameters used to monitor the response to the antiretroviral therapy.

them Name beta lactamase inhibitors and

LISt he limitations of crystaline penicllin and wavs to overcome
discuss their role in clinica! practice.

drugs. List the adverse effects and Uses o

Describe the mechanism of action of various classes of anti-enilentic
phenytoin?

(Ix12=12.00)
[Link] Answer Questions
a

glimepiride 6 mg once a day was

diabetes mellitus. was taking tablet
d i a man, a known case of tvpe 2 found to be hypoglycemic. He was given an
On admissinn to bosnitalhe was
oieitedand confused,
intravenous bolus of a drug XYZ and patient quickly recovered.
and what is its dose?
idtCOuld be the causes of hypoalvcemia
in this patient? ldentify the drug XYZ
patients on treatment to prevent such hypoglycemic
Descibe precautions that should be taken by diatbetic
episodes. (4 marks)
vildagliptin. (4 marKS)
b)What is the mechanism of action of glimepiride? Compare glimepiride with
mechanism of action. (4 marks)
c) Enumerate the other oral antidiabetic druas and mention their