The following is not true regarding about treatment of malignancy
A. Folinic acid rescue is given from approximately 12 h after the
methotrexate dose .
B. Bleomycin is myelotoxic and causes pulmonary fibrosis.
C. Radiation therapy is called a local treatment as it only affects the specific
area of the body that is targeted.
D. External beam nadiotherapy is irradiation of tumours at a ‘long’ distance
away from the source of ionizing radiation.
E. The organs at risk for pelvic radiation include the rectum, bladder, small
bowel and both hip joints.
Answer : B ( Bleoycinis not myelotoxic, the most important side-effect is
pulmonary fibrosis, which is dose related.)
The following are true regarding chemotherapy EXCEPT
A. Combination chemotherapy have a synergistic effect and reduced
resistance of tumour cells to therapy
B. Alkylating agents bind covalently to DNA via their alkyl group causing
their cancer effect.
C. Carboplantin is more frequently associated with nephrotoxicity.
D. Adriamycin causes tachycardia, heart failure and cardiomyopathy when
given in high doses.
E. Etoposide can increase the risk of a second cancer.
ANSWER:C ( Cisplatin - nephrotoxicity and associated hypomagnesaemia and
hypokalaemia and requires a forced diuresis and electrolyte replacement,
Carboplatin less frequently associated with nephrotoxicity or neurotoxicity )
The following is not a complication of pelvic radiotherapy
A.Vesico-vaginal fistula
B.Bone marrow toxicity
C.Rectal bleding
D.Stenosis
E.Ovarian failure
Answer:B ( It only affects the specific area of the body that is targeted )
