MOLECULAR BASIS OF INHERITANCE
5. In a DNA molecule, the phosphate group is
1. Which of the following is not consistent with attached to carbon ______ of the sugar residue
the base pairings in a double stranded DNA of its own nucleotide and carbon ______ of the
molecule? sugar residue of the next nucleotide by ______
bonds.
a. The number of C equals the number of G
(A) 5′, 3′, phosphodiester
b. The number of A equals the number of T (B) 3′, 5′, phosphodiester
(C) 5′, 3′, glycosidic
c. The amount of purine is equal to the amount of
(D) 3′, 5′, glycosidic
pyrimidine
d. The ratio of (G+C) to (A+T) for each species 6. Select the correct match of enzyme with its
related function.
(A) DNA polymerase - Synthesis of DNA strands
2. Refer the given figure of nucleosome and (B) Helicase -winding of DNA helix
select the option that correctly identifies the (C) Ligase - Joins together short RNA segments
parts A, B and C. (D) All are correct
7. The association of histone H1 with a
nucleosome indicates
A. DNA is condensed into chromatin fibers
B. Transcription is in progress
C. DNA replication is in progress
D. DNA double helix is exposed
A B C
(A) DNA Histone octamer H1 histone
8. DNA fragments are
(B) DNA H1 histone Histone
octamer A. Negatively charged
(C) Histone DNA H1 histone B. Positively charged
octamer C. Neutral
(D)HI histone DNA Histone D. Depends on the size
octamer
9. Taylor conducted the experiments to prove
3. Histone proteins are semi-conservative mode of chromosome
(A) basic, negatively charged replication on
(B) basic, positively charged. A. Vicia faba
(C) acidic, positively charged B. Vinca rosea
(D) acidic, negatively charged C. [Link]
D. Drosophila
4. Select the incorrect statement regarding 10. Which of the following nitrogenous bases is
DNA replication. found only in RNA?
(A) Leading strand is formed in 5′ → 3′ direction. A. Adenine
(B) Okazaki fragments are formed in 5′ → 3′ B. Thymine
direction. [Link]
(C) DNA polymerase catalyses polymerization in [Link]
5′ → 3′ direction.
(D) DNA polymerase catalyses polymerization in 11. Which of the following is a nucleoside
3′ → 5′ direction. A. Adenosine monophosphate
B. Ribozyme 18. In the DNA molecule:
C. Thymidine A. The proportion of adenine in relation to
D. Cytosine thymine varies with the organism.
B. There are two strands which run
12. Which of the following statements is false antiparallel, one in 5’ → 3’ direction and
for a double stranded DNA molecule? other in 3’ → 5’.
A. Ratio of Adenine :Thymine is 1. C. The total amount of purine nucleotides and
B. Ratio of Adenine: Guanine is 1. pyrimidine nucleotides is not always equal.
C. Ratio of A+T : G+C is 1. D. There are two strands which run parallel in
D. Ratio of Guanine:Cytosine is 1. the 5’ → 3’ direction.
13. The basic building blocks of DNA are: 19. Which of the following is the characteristic
A) Amino acids feature of an organism?
B) Nucleotides A) Number of RNA
C) Fatty acids B) Number of protein molecules
D) Monosaccharides C) Length of chromosomes
D) Length of DNA
14. DNA replication takes place during which
phase of the cell cycle? 20. Which of the following statements is correct
with respect to purines?
A) Interphase
A) Purines are heterocyclic compounds
B) Prophase
B) Purines are 7 membered structure
C) Metaphase
C) Purines are single-ring structure
D) Anaphase
D) Thymine is an example of purine
15. The process of converting DNA into RNA is
21. Which of the following statement is
called:
incorrect with respect to pyrimidines?
A) Transcription A) Heterocyclic
B) Translation B) 7 membered ring
C) Replication C) Cytosine is an example of pyrimidine
D) Duplication D) Single-ring structure
16. If a double-stranded DNA has 20% of 22. The primer in DNA replication is:
cytosine, what will be the percentage of adenine A) Small ribonucleotide polymer
in it? B) Helix destabilizing protein
A. 20% C) Small deoxyribonucleotide polymer
B. 40% D) Enzyme joining nucleotides of new strands
C. 30%
D. 60% 23. Select the incorrectly matched pairs:
A) Purines – Nitrogenous bases cytosine, thymine,
17. Histones are rich in: and uracil
A. lysine and histidine. C) Recombinant DNA – DNA formed by joining
B. valine and histidine. the DNA segments from two different sources
C. arginine and lysine. C) rRNA – RNA found in ribosomes
D. arginine and histidine. D) ATP – The energy-carrying compound in the
cell
24. What is the length of DNA having 75 base
pairs?
A)255 Å
B)112.5 Å
C)750 Å
D)none of these
25. Okazaki fragments are
A. Short DNA fragments on the lagging strand
B. Short DNA fragments on the leading strand
C. The RNA primers required for initiation of
DNA synthesis
D. The DNA fragment produced due to radiation
action
26. Who experimentally proved semi
conservative model of DNA replication
A. Frederic Griffith B. Meselson & Stahl
C. Watson & Crick D. Chargaff
27. What is the difference between adenosine
and deoxyadenosine ?
A) Only sugar
B) Only purine
C) Only phosphate
D) All of these
28. Which of the following are all nucleotides ?
A) Adenosine, cytidilic acid, cytosine
B) Adenylic acid, cytidilic acid, guanylic acid
C) Cytidine, adenine, adenylic acid
D) Uracil, thymidine, thymidylic acid
29. X-ray data diffraction of DNA was
produced by
A) Watson and Crick
B) Wilkins and Franklin
C) Bateson and Punnett
D) Both (a) and (b)
30. Semiconservative mode of DNA replication
was first demonstrated in
A) Salmonella typhimurium
B) Drosophila melanogaster
C)Streptococcus pneumoniae
D) Escherichia coli
ANSWER KEY
1 2 3 4 5 6 7 8 9 10
D C C D A A A A A C
1 1 1 2 2 2 2
17 21 25
6 8 9 0 2 3 4
C C B D A B A A A A
