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Gujarat Technological University: Pharm.D Year-4/ Pharm.D (PB) Year-1 Examination - Winter - 2024

This document outlines the examination details for the Biopharmaceutics & Pharmacokinetics subject at Gujarat Technological University for Pharm.D students. It includes the exam date, time, total marks, and instructions for attempting the questions. The document also lists various questions covering topics such as dissolution rate mechanisms, absorption rate constants, and bioequivalence study protocols.

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sumanpanchal2003
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22 views1 page

Gujarat Technological University: Pharm.D Year-4/ Pharm.D (PB) Year-1 Examination - Winter - 2024

This document outlines the examination details for the Biopharmaceutics & Pharmacokinetics subject at Gujarat Technological University for Pharm.D students. It includes the exam date, time, total marks, and instructions for attempting the questions. The document also lists various questions covering topics such as dissolution rate mechanisms, absorption rate constants, and bioequivalence study protocols.

Uploaded by

sumanpanchal2003
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Seat No.: _____ Enrolment No.

_____________

GUJARAT TECHNOLOGICAL UNIVERSITY


PHARM.D YEAR-4/ PHARM.D (PB) YEAR-1 EXAMINATION – WINTER - 2024

Subject Code: 848805/818905 Date: 12-12-2024


Subject Name: Biopharmaceutics & Pharmacokinetics
Time: 10 : 30 AM TO 1 : 30 PM Total Marks: 70
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Enlist models for dissolution rate mechanisms. Explain Diffusion layer model 06
in detail.
(b) What is the difference between absolute and effective surface area? How can 04
the latter of a hydrophobic drug be increased?
(c) Write a note on In vitro methods used in kinetic study of protein binding. 04
Q.2 (a) How do you determine the absorption rate constant by the method of residuals? 06
(b) Derive an equation that describe the unchanged drug excretion in urine 04
following Sigma-Minus method.
(c) Discuss the factors affecting renal excretion. 04
Q.3 (a) Write about Loo-Riegelman method used for the determination of absorption 06
rate constant follows a two-compartment open model.
(b) Explain simultaneous IV injection and infusion are used for an immediate 04
therapeutic effect.
(c) Give equation for two compartment open model for IV bolus administration. 04
What are the assumptions to be considered in developing equations for two
compartment open model?
Q.4 (a) How multiple dose regimen for IV bolus is determined? 06
(b) Write note on statistical moment theory. 04
(c) Explain the phenomenon of drug accumulation. 04
Q.5 (a) Write a note on Michaelis Menten method of estimating parameters. 06
(b) Write a detailed note on factors causing non-linearity. 04
(c) Enlist the elements of a bioequivalence study protocol. Why washout period 04
has to be given in a bioavailability study?
Q. 6 (a) Discuss the methods aimed at enhancing bioavailability through enhancement 06
of drug solubility or dissolution rate.
(b) Write about the pharmacokinetic method used for the assessment of 04
bioavailability.
(c) Write the three-liner equation and their plots obtained by rearranging the 04
Michaelis Menten equations.
Q.7 (a) Write note on physiologic pharmacokinetic model. 06
(b) Classify the bioequivalence experimental study designs. Write about Latin- 04
Square design in detail.
(c) Explain various levels in in vitro-in vivo correlations. 04

***************

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