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Gujarat Technological University

This document outlines the examination details for the Biopharmaceutics and Pharmacokinetics subject at Gujarat Technological University for Pharm D Year-4 and Pharm D (PB) Year-1 students. It includes instructions for the exam, a list of questions covering various topics such as the Michaelis Menten equation, drug absorption, and pharmacokinetic models, with a total of 70 marks available. Students are required to attempt any five questions and make suitable assumptions where necessary.

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sumanpanchal2003
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18 views1 page

Gujarat Technological University

This document outlines the examination details for the Biopharmaceutics and Pharmacokinetics subject at Gujarat Technological University for Pharm D Year-4 and Pharm D (PB) Year-1 students. It includes instructions for the exam, a list of questions covering various topics such as the Michaelis Menten equation, drug absorption, and pharmacokinetic models, with a total of 70 marks available. Students are required to attempt any five questions and make suitable assumptions where necessary.

Uploaded by

sumanpanchal2003
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Seat No.: _____ Enrolment No.

_____________

GUJARAT TECHNOLOGICAL UNIVERSITY


PHARM D YEAR-4/ PHARM.D (PB) YEAR-1 EXAMINATION – SUMMER -2024

Subject Code: 848805/818905 Date:16/05/2024


Subject Name: Biopharmaceutics and Pharmacokinetics
Time: 10:30AM TO 01:30PM Total Marks: 70
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Write a note on Michaelis Menten equation for estimation of Km and Vmax. 06
(b) Discuss causes of non - linearity with examples. 04
(c) Write a note on Statistical moment theory. 04
Q.2 (a) Write a note on Mammillary and Catenary Model. 06
(b) Discuss merits and demerits of non-compartmental pharmacokinetics. 04
(c) Write a note on Physiological Pharmacokinetic model. 04
Q.3 (a) Define Bioavailability. Explain various methods used for determination of 06
Bioavailability.
(b) Write a note on elements of Bioavailability study protocol 04
(c) Discuss Latin square design in Bioequivalent study 04
Q.4 (a) Define Drug Absorption. Enumerate various factors influencing GI absorption 06
of a drug. Discuss Pharmaceutical factors in detail.
(b) Discuss various barriers of Drug Distribution. 04
(c) Explain Passive Diffusion in detail. 04
Q.5 (a) Explain One compartment open model for IV infusion. 06
(b) Discuss the factors affecting renal excretion. 04
(c) Define: (1) Peak plasma concentration (2) Area under the curve (3) Minimum 04
effective Concentration (4) Duration of action
Q. 6 (a) Explain Wagner Nelson method for computing absorption rate constant. 06
(b) Explain two compartment open model for IV bolus administration. 04
(c) Write a note on Apparent volume of distribution and its significance. 04
Q.7 (a) How Multiple dose regimen for IV bolus is determined? 06
(b) How elimination rate can be determined using Urinary Excretion Data? 04
(c) Describe any four methods to enhance the bioavailability through enhancement 04
of Dissolution rate.

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