Dept of Pharmacology,
GAIMS, Bhuj
Tetracyclines Induced Discoloration of Teeth
Tetracyclines Induced Discoloration of
Teeth
Drugs that cause this adverse effect.
Tetracycline
Demeclocycline
FIXED DRUG ERUPTION
FIXED DRUG ERUPTION
Fixed drug eruption
It is a cutaneous drug reaction that characteristically
recurs in same position on re-exposure to offending
drug/s
Drugs that cause this adverse effect.
Sulphonamides
Dapsone
Ciprofloxacin
Doxycycline
Trimethoprim
Fluconazole
URTICARIA
Urticaria
Commonly referred to as hives, is a kind of
skin rash characterized by red, raised, itchy
papules or patches.
Hives might also cause a burning or stinging
Sensation
Drugs that cause this Adverse Effects
Sulphonamides
Penicillins
Ibuprofen
EXFOLIATIVE DERMATITIS
Exfoliative Dermatitis
Exfoliative dermatitis is peeling of the skin
over large areas of the body.
The term “exfoliative” refers to the
exfoliation, or shedding of the skin
“Dermatitis means irritation of the skin
Drugs that cause this Adverse Effects
Penicillin
Phenytoin
Isoniazid
Angioedema
Angioedema
Manifestation of allergic disorder
Angioedema is the rapid swelling of the dermis,
Subcutaneous tissue, mucosa & submucosal tissues
Swelling usually occurs around the eyes and lips
It may also be found on the hands, feet and throat
Drugs that cause this Adverse Effects
• ACE inhibitors (Captopril, Enalapril)
Oral candidiasis
Oral candidiasis (Thrush)
Candida albicans is the most common fungus
implicated organism in this condition. Thrush occurs
when immunity is poor
Drugs that cause this Adverse Effects
Glucocorticoids (Betamethasone, Prednisolone)
What is the treatment of oral candidiasis ?
Nystatin- Oral Application
Amphotericin B
Gynaecomastia
Gynaecomastia
Gynecomastia is a common condition
characterized by the benign enlargement
of breast tissues in males
Drugs that cause this Adverse Effects
Digitalis
Cimetidine
Spironolactone
Ketoconazole
Gum hypertrophy
Gum hypertrophy
It an increase in the size of the gingiva
(gums)
Drugs that cause this Adverse Effects
Phenytoin
Cyclosporine
Hirsutism
Hirsuitism
Hirsuitism is a condition of unwanted, male
pattern hair growth in women
Drugs that cause this Adverse Effects
Phenytoin
Cyclosporine
Facial Dystonia
Facial Dystonia
Dystonia is a general term which describes
involuntary movements and extended
muscle contractions – a range of
movements disorders.
Drugs that cause this Adverse Effects
Metoclopramide
Haloperidol
Steroids induced striae
Steroids induced striae
Steroids induced striae
Local and discoloration of skin in patches
Drugs that cause this Adverse Effects
Glucocorticoids
(Betamethasone, Prednisolone)
Cushings syndrome
Cushings syndrome
Cushings syndrome is a disorder that occur
when your body is exposed to high levels of
hormone cortisol.
It may also occur if you take too much cortisol
or other steroid hormone
Drugs that cause this Adverse Effects
Glucocorticoid
(Betamethasone, Prednisolone)
Phocomelia
Phocomelia
It is an extremely rare congenital disorder involving
malformation of the limbs
Drugs that cause this Adverse Effects
Thalidomide
Phototoxicity
Phototoxicity
Phototoxicity is an inflammatory skin reaction
caused by exposure to a chemical and
subsequent exposure to sunlight
Drugs that cause this Adverse Effects
• Quinolones
• Tetracyclines
• Sulphonamides
Erythema Multiforme
Erythema multiforme
Erythema multiforme is a type of
hypersensitivity reaction.
Drugs that cause this Adverse Effects
Penicillins
Sulphonamides
Phenytoin
Steven Johnson syndrome
Steven Johnson syndrome
• Immune complex mediated adverse drug
effect involving less than 10% body area
• Is a form of a life threatening skin condition
in which cell death cause epidermis to
separate from dermis
Drugs that cause this Adverse Effects
• Penicillins
• Sulphonamides
• Phenytoin
Toxic epidermal necrolysis
Toxic epidermal necrolysis
• Immune complex mediated adverse drug effect involving more than
30% body area
Drugs that cause this Adverse Effects
• Indomethcin
• Penicillins
• Phenytoin
Drug induced acne-form eruption
Drug induced acneiform eruptions
• Acneiform eruption refers to a group of
dermatoses including acne vulgaris, rosacea,
folliculitis, perioral dermatitis
Drugs that cause this Adverse Effects
• Phenytoin
• Isoniazid
• Lithium
• Iodides
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