Worksheet: Transmission of Action Potential Through a Synapse
Name: ___________________________
Date: ___________________________
Class: __________________________
Part A: Labelling the Synapse Diagram
Label the numbered parts of the diagram below related to synaptic transmission. Use the
word bank to help you.
Word Bank:
- Synaptic cleft
- Axon terminal
- Neurotransmitters
- Synaptic vesicle
- Postsynaptic membrane
- Receptor protein
- Action potential
- Mitochondrion
-Synaptic Knob
Action potential
Axon terminal
Synaptic vesicles
Synaptic knob
Mitochondrion
Neurotransmitter
Synaptic cleft
Receptor proteins
Post synaptic
membrane
Part B: Steps in Synaptic Transmission
Put the following steps in the correct sequence (1 to 7) to show how an action potential is
transmitted across a synapse.
Instructions: Write the number 1 for the first step, 2 for the second, and so on.
Steps Order
Neurotransmitters are released into the ___
synaptic cleft.
An action potential reaches the axon ___
terminal.
Calcium ions enter the axon terminal. ___
Neurotransmitters bind to receptors on the ___
postsynaptic membrane.
Synaptic vesicles fuse with the presynaptic ___
membrane.
A new action potential is generated in the ___
postsynaptic neuron.
Calcium ion channels open in response to ___
depolarization.
Part C: Free Response (Short Answer)
1. How is synaptic transmission ensured to be forward moving only?
The way neurotransmitters are released and received at the synapse
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2. What role do neurotransmitters play in this process?
They act as a chemical messenger and plays in both the release and reception of signals
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between neurons
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3. What would happen if neurotransmitters were not removed from the synaptic cleft?
The receiving neuron will experience a prolonged and excessive
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stimulation
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