Breathing and Exchange of Gases –
NEET Short Notes
1. Introduction
Respiration is the biochemical process involving the exchange of gases, mainly oxygen and
carbon dioxide, between the environment and the cells of the body. It includes breathing,
gas transport, and cellular respiration.
2. Human Respiratory System
External nostrils → Nasal cavity → Pharynx → Larynx → Trachea → Bronchi → Bronchioles →
Alveoli.
Alveoli are the primary sites for gaseous exchange. They are thin-walled and surrounded by
capillaries.
3. Mechanism of Breathing
Inspiration: Diaphragm contracts and flattens, external intercostal muscles contract →
thoracic volume increases → air enters lungs.
Expiration: Diaphragm relaxes and curves upwards, internal intercostals contract →
thoracic volume decreases → air is expelled.
4. Respiratory Volumes and Capacities
Tidal Volume (TV): 500 mL – Volume of air inhaled or exhaled during normal breathing.
Inspiratory Reserve Volume (IRV): 2500–3000 mL – Extra volume inhaled after normal
inspiration.
Expiratory Reserve Volume (ERV): 1000–1100 mL – Extra volume exhaled after normal
expiration.
Residual Volume (RV): 1100–1200 mL – Volume remaining after forced expiration.
Vital Capacity (VC) = TV + IRV + ERV.
Total Lung Capacity (TLC) = VC + RV.
5. Exchange of Gases
Occurs by simple diffusion based on partial pressure gradients.
Oxygen diffuses from alveoli → blood → tissues.
Carbon dioxide diffuses from tissues → blood → alveoli.
6. Transport of Gases
Oxygen Transport
98.5% transported as oxyhemoglobin, 1.5% dissolved in plasma.
Each hemoglobin (Hb) binds 4 molecules of O₂.
Bohr Effect: Increase in CO₂ or H⁺ reduces Hb-O₂ affinity → promotes O₂ release.
Carbon Dioxide Transport
70% as bicarbonate (HCO₃⁻), 20-25% as carbaminohemoglobin, 7% dissolved in plasma.
Chloride Shift: Exchange of HCO₃⁻ with Cl⁻ to maintain ionic balance.
7. Regulation of Respiration
Medulla oblongata: Controls rhythm of breathing.
Pneumotaxic center (pons): Modulates rate and depth.
Chemoreceptors: Respond to CO₂, O₂, and H⁺ concentrations.
8. Respiratory Disorders
Asthma: Inflammation and narrowing of bronchioles due to allergy.
Emphysema: Damage to alveolar walls, reduced surface area, commonly caused by smoking.
Occupational Disorders: Caused by inhaling harmful particles (e.g., silicosis, asbestosis).