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The document discusses various anthroquinone derivatives and their properties, particularly focusing on compounds such as aloe emodin and chrysophanic acid, which possess purgative effects. It also highlights the challenges in quantitatively determining glycerin in pharmaceutical preparations, noting that existing methods are often unsatisfactory due to interference and variability in results. The author advocates for the development of a simpler and more reliable method for glycerin estimation.

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13 views1 page

First Page PDF

The document discusses various anthroquinone derivatives and their properties, particularly focusing on compounds such as aloe emodin and chrysophanic acid, which possess purgative effects. It also highlights the challenges in quantitatively determining glycerin in pharmaceutical preparations, noting that existing methods are often unsatisfactory due to interference and variability in results. The author advocates for the development of a simpler and more reliable method for glycerin estimation.

Uploaded by

kutlusoy.gamze06
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

AMIRICANPHARMACEUTICAL

ASSOCIATION 75
Oesterle, ( 191I ) , states, regarding the oxymethylaiithroquinones, that aloe
emodin reduced, forms chrysophanic acid, but oxidized, forms rlacin, while
chrysophanic acid oxidized, likewise forms rhein.
Tutin and Clewer, (1911 ) ) state that the anthroquinone derivatives from
rh ubar b,-rhein, em odin, aloe-emodin, f ra ngaila-emodin, emodiiz-mo no metlzyl-
ether and chrysophanic acid, are derived f rom medicinally inert glucosides ; that
only ajoe-emodin and chrysophanic acid possess purgative properties, and that
most of the purgative value of the drug, lies in a non-glucosidic resin which they
isolated.
Kosenthaler, ( 1911), presents a list of anthroquinone drugs distinguished from
one another by the physical characters of their micro-sublimates and the cdor-
reaction of these sublimates in alcoholic solution with ferric chloride solution.
Schmidt, (1912), describes frangulin, (rhamnoxanthifz), (C,,H,,O,), as oc-
curring in lemon-yellow, glistening, fine needle-crystals, odorless and tasteless,
melting at 228" to 230" C. I t is almost insoluble in water and in cold ether, but
soluble in 180 parts of 80% hot alcohol. Concentrated sulphuric acid dissolves
it with' a dark-red color and with caustic alkalies it forms solutions of a purple-
red color. By boiling with an alcoholic solution of hydrochloric acid, it be-
comes converted into rlzamibose and fraizgnlu-emodin, (C,,H,,O,) , which forms
bright-red, glistening needles melting at 255" C. I t is insoluble in water, slightly
soluble in alcohol and easily in chloroform and benzol In ammonia it dissolves
with a red, slightly bluish color.
(To be continued.)

A N E W METHOD F O R THE ESTIMATION OF GLYCERIN I N PHAR-


MACEUTICAL PREPARATIONS.
~~ ~

C . 13. BRIGGS, M . S .

Glycerin is one of the most common and generally used sub-


stances in pharmacy and yet its quantitative determination in
Pharmaceutical preparations presents many difficulties. On several
occasions in our laboratory it has been necessary to attempt to assay
for glycerin such preparations as elixirs, tooth-pastes, shaving
soaps, liquid face creams, and essences of pepsin, and the results
have been far from satisfactory. Several methods with necessary
modifications to adapt them to the particular preparations were tried, but in some
cases the duplicate results showed marked variations, thus making doubtful the
reliability of the process.
The official methods for the determination of glycerin in wines are not applica-
ble to all pharmaceutical preparations because of interfering substances and, to
say the least, they are long and tedious. (See Allen's Organic Analysis, Vol. 1,
page 167.)
It would seem therefore that a simple and reliable method for the estimation

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