QP CODE: 213327 Reg. No:………………….
Second Semester M. Pharm Degree Supplementary Examinations
September 2022
[Link] (Pharmaceutics)
Paper III: Computer Aided Drug Development (MPH 203T)
Time: 3 Hours Total Marks: 75
Answer all questions to the point neatly and legibly • Do not leave any blank pages between
answers • Indicate the question number correctly for the answer in the margin space
Answer all parts of a single question together • Leave sufficient space between answers
Draw table/diagrams/flow charts wherever necessary
Essays (3x10=30)
1. Explain patents as an IPR tool for protection of innovative uses of computers.
2. Describe parameter sensitive analysis, virtual trials, model construction and ACAT model
with respect to computer aided biopharmaceutical characterization of drugs.
3. Explain the future direction of artificial intelligence in pharma. Discuss the role of
computational fluid dynamics in pharmaceutical industry
Short Notes (9x5=45)
4. Explain the statistical modelling in pharmaceutical research and development
5. Discuss the levels of computer simulations in pharmacokinetics and pharmacodynamics.
6. Write the steps of quality by design. Explain the role of ICH Q8 guideline in quality by
design.
7. Write about different computational approaches used in modelling the solubility of drugs.
8. Discuss the factors to be considered and computational modelling techniques to study
intestinal permeation.
9. Explain the approaches used in modelling the solubility of drug molecules.
10. Brief various levels in computer simulation.
11. Explain the application of machine learning in pharma industries
12. Discuss the use of computers in market analysis
******************
QP CODE: 213327 Reg. No:………………….
Second Semester M. Pharm Degree Regular/Supplementary Examinations
February 2021
[Link] (Pharmaceutics)
Paper III: Computer Aided Drug Development (MPH 203T)
Time: 3 Hours Total Marks: 75
Answer all questions to the point neatly and legibly • Do not leave any blank pages between
answers • Indicate the question number correctly for the answer in the margin space
Answer all parts of a single question together • Leave sufficient space between answers
Draw table/diagrams/flow charts wherever necessary
Essays (3x10=30)
1. Narrate the computational modeling of drug disposition
2. Explain about the computer aided formulation development of pharmaceutical micro
emulsion
3. Define optimization and describe about the concept of optimization, optimization
parameters and factorial design with the use of computers
Short Notes (9x5=45)
4. Population modeling
5. Scientifically based QbD and its applications
6. Legal protection of innovative uses of computers in research and development
7. Computers in market analysis
8. Bio wavier considerations
9. Computer simulation in organs and genes
10. Regulation of computer systems.
11. Computational fluid dynamics
12. Artificial intelligence using robotics in pharmaceutical automation
******************
QP CODE: 213327 Reg. No:………………….
Second Semester M. Pharm Degree Supplementary Examinations
January 2020
[Link] (Pharmaceutics)
Paper III: Computer Aided Drug Development (MPH 203T)
(2017 Scheme)
Time: 3 Hours Total Marks: 75
Answer all Questions.
Draw Diagrams wherever necessary.
Essays (3x10=30)
1. Explain the drug absorption model and drug excretion model.
2. Describe the various statistical modeling in pharmaceutical research and development.
3. Explain the optimization technology and screening design in computer aided formulation
and development
Short Notes (9x5=45)
4. Sensitivity analysis.
5. BBB-choline transporter.
6. Computers in market analysis
7. Computational fluid dynamics in pharmaceutical application.
8. OCT (Organic Cation Transporter).
9. Role of computer in pharmaceutical R&D.
10. Computer simulation of gene.
11. Regulatory and industry views on quality by design.
12. Current challenges of robotics in pharmaceuticals
******************
Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
M. Ph. – SEMESTER II • EXAMINATION – WINTER -2022
Subject Code: MPH203T Date:16/12/2022
Subject Name: Computer Aided Drug Development
Time: 10:30am to 01:30pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) What is QbD? Explain elements of QbD. 06
(b) Discuss about screening designs used in pharmaceutical formulation 05
development.
(c) Describe history of computers in pharmaceutical research and development. 05
Q.2 (a) What do you mean by design space? Explain with example. 06
(b) Explain in short about sensitivity analysis. 05
(c) What is statistical modeling? Explain its parameter and estimation. 05
Q.3 (a) Describe general modeling and simulation strategy GI simulation. 06
(b) What is P-gp? Give its significance in drug transport. 05
(c) Explain the terms PEPTI and OATP. 05
Q.4 (a) Describe general protocol for IVIC Study. 06
(b) What is in-vitro in-vivo correlation? Describe the significance of IVIC 05
correlation in pharmaceutical drug developments.
(c) Write a note on biowaiver considerations. 05
Q.5 (a) What is hPEPT1? Give its significance in drug transport. 06
(b) Compare the human GIT physiology between fasted and fed states. 05
(c) Explain computer simulation of whole organism and isolated tissues. 05
Q. 6 (a) Explain methods of data collection in clinical trials. 06
(b) Write a note on ethics of computing in pharmaceutical research 05
(c) Explain in short about Data collection and data management. 05
Q.7 (a) Write a note on Artificial Intelligence and Robotics. 06
(b) Write application, advantages, and disadvantages of pharmaceutical 05
automation.
(c) Describe role of computers in market analysis? 05
***************
Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
M. Pharm- SEMESTER– II EXAMINATION– WINTER-2021
Subject Code:MPH203T Date: 19/02/2022
Subject Name: Computer Aided Drug Development
Time: 10:30 AM to 1:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) What is computational fluid dynamics (CFD). Give the applications of CFD in 06
Pharmacy
(b) Explain the automation in pharmaceutical industry 05
(c) Write a note on application of robotics in field of pharmacy 05
Q.2 (a) Describe the organization of neural network and explain the steps involved in 06
construction and testing of the ANN
(b) Discuss IVIVC correlation with respect to computer simulation 05
(c) What are the advantages of PBPK modeling and how it can be used for 05
biowaivers?
Q.3 (a) Explain ACAT model in detail 06
(b) Elaborate with suitable examples the role of computers in formulation 05
development of emulsions
(c) Write a note on ethics of computing in pharmaceutical research 05
Q.4 (a) What is statistical modeling and differentiate between mechanistic and 06
empirical modeling
(b) How the innovative uses of the computers in research are protected legally? 05
(c) How computers are useful in market analysis? 05
Q.5 (a) Discuss in brief, the various elements of QbD based pharmaceutical 06
development
(b) Write a note on sensitivity analysis 05
(c) Explain the role of computers in clinical data collection & management 05
Q. 6 (a) Enlist various modeling techniques used for drug disposition and explain any 06
two in detail.
(b) Describe the various factors/modeling targets to be considered during 05
molecular modeling of drug disposition.
(c) What do you understand by the term active transport and nucleoside 05
transporters and where they are located? Explain in brief P-gp, & BCRP
relation to drug disposition
Q.7 (a) Discuss in detail ICH Q8guideline 06
(b) What is optimization and discuss the popular experimental designs for 05
optimization
(c) Write a note on screening designs. 05
***************
[Link]
Printed Pages : 1 Roll No. MPH-203
M. PHARMA.
THEORY EXAMINATION (SEM–II) 2016-17
COMPUTER AIDED DRUG DELIVERY SYSTEM
Time : 3 Hours Max. Marks : 70
Note : Be precise in your answer. In case of numerical problem assume data wherever not provided.
SECTION- A
1. Attempt all parts of this Section : 7×2=14
(a) What do you mean by ‘population modeling’?
(b) Name two major active drug transporters and their functions.
(c) What do you mean by computational modeling of ADMET?
(d) Name two softwares used in the computer aided formulation development of
microemulsion drug carriers.
(e) Mention the biowaiver considerations.
(f) Mention the applications of robotics in pharmacy.
(g) Define ‘artificial intelligence’.
SECTION- B
[Link]
2. Attempt any three parts of the following : 3×7=21
(a) Write a brief note on descriptive versus mechanistic modelling.
(b) Describe the role of active transporters in drug absorption and distribution in the body.
(c) Mention the use of computers in formulation development of pharmaceutical emulsion
carriers.
(d) Write a brief note on the use of computers in clinical data collection and management.
(e) Mention the various fields of pharmaceutical automation.
SECTION- C
3. Attempt all questions in this section : 5×7=35
(a) Explain the significance of using statistical modelling in pharmaceutical research and
development.
OR
How sensitivity analysis can be done with the help of computers?
(b) Write a brief note on computational modelling techniques on any one of the following:
(i) Nucleoside transporters
(ii) Drug absorption in the body.
(c) Write a brief note on any one of the following:
(i) Legal protection of innovative uses of computers in R & D.
(ii) Ethics of computing in pharmaceutical research.
(d) How virtual trials are conducted in biopharmaceutical characterization using
computers?
OR
Describe the role of computers in IVIVC.
(e) Mention the advantages and disadvantages of pharmaceutical automation.
OR
How robotics is implied in pharmacy?
[Link]
[Link]
Printed Pages:01 Sub Code: MPH 203T
Paper Id: 2 5 6 2 0 9 Roll No.
M. PHARM.
(SEM II) THEORY EXAMINATION 2017-18
COMPUTER AIDED DRUG DELIVERY SYSTEM
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.
SECTION A
1. Attempt all questions in brief. 10 x 2 = 20
a. What are the different levels of variables?
b. Define discrete and continuous data?
c. How Cadila System is used for simulation?
d. Define Quality by Design.
e. What do you understand by confidence regions?
f. What do you understand by sensitivity analysis?
g. Give the various points considered in computer ethics?
[Link]
h. What is Monte Carlo simulation?
i. Write the advantages of artificial intelligence.
j. What do you understand by BCRB?
SECTION B
2. Attempt any two parts of the following: 2 x 10 = 20
a. Write a detailed role of computers in pharmaceutical formulations.
b. How computers are helpful for clinical data collection and management?
c. What do you understand by emulsions? How computers are useful for development of
emulsions by using simulation.
SECTION C
3. Attempt any five parts of the following: 5 x 7 = 35
a. Write a note on population modeling in pharmaceutical research and development.
b. Write a detailed note on In-vitro dissolution and in-vitro-in vivo correlation.
c. Give the details about ethics in computing with respect to pharmaceutical research.
d. What is mechanistic modeling? What are the advantages of mechanistic modeling?
e. Discuss the mechanism of drug absorption. How computer simulation is useful in drug
absorption?
f. Write a detailed note on artificial intelligence.
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e.c
g. Write a detailed note on biowaiver consideration.
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